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[+] expand all[+] SLC1 High-affinity glutamate and neutral amino acid transporter family
References
Original version of the SLC table:
Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr;34(2-3):108-20.
Original version of the SLC table:
Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr;34(2-3):108-20.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC1A1 | EAAC1, EAAT3 | System X-AG | C / Na+, H+, K+ | L-Glu, D/L-Asp | brain (neurons), intestine, kidney, liver, heart, placenta |
SLC1A2 | GLT-1, EAAT2 | System X-AG | C / Na+, H+, K+ | L-Glu, D/L-Asp | brain (astrocytes, Bergmann glia, neurons), liver, pancreas |
SLC1A3 | GLAST, EAAT1 | System X-AG | C / Na+, H+, K+ | L-Glu, D/L-Asp | brain (astrocytes, Bergmann glia), heart, skeletal muscle, placenta |
SLC1A4 | ASCT1, SATT | System ASC | C / Na+, E / amino acids | L-Ala, L-Ser, L-Cys, L-Thr | widespread |
SLC1A5 | ASCT2, AAAT | System ASC | C / Na+, E / amino acids | L-Ala, L-Ser, L-Cys, L-Thr, L-Gln, L-Asn | lung, skeletal muscle, large intestine, kidney, testis, adipose tissue |
SLC1A6 | EAAT4 | System X-AG | C / Na+, H+, K+ | L-Glu, D/L-Asp | cerebellum (Purkinje cells) |
SLC1A7 | EAAT5 | System X-AG | C / Na+, H+, K+ | L-Glu, D/L-Asp | retina (rod photoreceptors, bipolar cells) |
[+] SLC2 Facilitative GLUT transporter family
References
Original version of the SLC table:
Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr;34(2-3):121-38.
Original version of the SLC table:
Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr;34(2-3):121-38.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC2A1 | GLUT1 | F | glucose, galactose, mannose, glucosamine | erythrocytes, brain, blood-brain barrier, blood-tissue barrier, many fetal tissues | |
SLC2A2 | GLUT2 | F | glucose, galactose, fructose, mannose, glucosamine | liver, islet of Langerhans, intestine, kidney, brain | |
SLC2A3 | GLUT3 | F | glucose, galactose, mannose, xylose | brain (neurons), testis | |
SLC2A3P1 | pseudogene | GLUT3 pseudogene 1 | |||
SLC2A3P2 | pseudogene | GLUT3 pseudogene 2 | |||
SLC2A3P4 | pseudogene | GLUT3 pseudogene 4 | |||
SLC2A4 | GLUT4 | F | glucose, glucosamine | adipose tissue (white, brown), skeletal, cardiac muscle | |
SLC2A5 | GLUT5 | F | fructose | small intestine, kidney | |
SLC2A6 | GLUT6 | GLUT9 | F | glucose | brain, spleen, leucocytes |
SLC2A7 | GLUT7 | F | glucose, fructose | small intestine, colon, testis, prostate | |
SLC2A8 | GLUT8 | GLUTX1 | F | glucose, fructose, galactose | testis, brain, adrenal gland, liver, spleen, brown adipose tissue, lung |
SLC2A9 | GLUT9 | GLUTX, URATv1 | urate (glucose, fructose) | kidney, liver, small intestine, placenta, lung, leucocytes | |
SLC2A10 | GLUT10 | F | glucose, galactose | heart, lung, brain, liver, skeletal muscle, pancreas, placenta, kidney | |
SLC2A11 | GLUT11 | GLUT10 | F | glucose, fructose | heart, muscle |
SLC2A12 | GLUT12 | GLUT8 | F | glucose | heart, prostate, skeletal muscle, placenta |
SLC2A13 | HMIT | GLUT13 | C / H+ | myo-inositol | brain, adipose tissue |
SLC2A14 | GLUT14 | SLC2A3P3 | O | testis | |
SLC2AXP1 | pseudogene |
[+] SLC3 Heavy subunits of the heteromeric amino acid transporters
References
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC3A1 | rBAT | NBAT, D2H | E (see details in SLC7 table) | system b0,+, heterodimerizes with light subunit SLC7A9 | kidney, small intestine, liver, pancreas |
SLC3A2 | 4F2hc | CD98hc, FRP | E (see details in SLC7 table) | systems L, y+L, xc- and asc with light subunits SLC7A5-8 and SLC7A10-11 | ubiquitous |
[+] SLC4 Bicarbonate transporter family
References
Original version of the SLC table:
Romero MF, Chen AP, Parker MD, Boron WF. The SLC4 family of bicarbonate (HCO3(-)) transporters. Mol Aspects Med. 2013 Apr;34(2-3):159-82.
Original version of the SLC table:
Romero MF, Chen AP, Parker MD, Boron WF. The SLC4 family of bicarbonate (HCO3(-)) transporters. Mol Aspects Med. 2013 Apr;34(2-3):159-82.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC4A1 | AE1 | Band 3 | E | chloride cicarbonate | erythrocytes, intercalated cells of renal collecting duct, heart, colon |
SLC4A2 | AE2 | E | chloride bicarbonate | widely distributed | |
SLC4A3 | AE3 | E | chloride bicarbonate | brain, retina, heart, smooth muscle, also epithelial cells of kidney, GI tract | |
SLC4A4 | NBCe1 | NBC, NBC1 | C | sodium bicarbonate (and/or carbonate) | NBCe1-A: renal proximal tubule, eye, NBCe1-B: widely distributed, pancreas, heart, eye, NBCe1-C: brain |
SLC4A5 | NBCe2 | NBC4 | C | sodium bicarbonate (and/or carbonate) | liver, testes, spleen |
SLC4A7 | NBCn1 | NBC2, NBC3, SLC4A6 | C | chloride bicarbonate | widely distributed, spleen, testes, brain, heart, lung, liver, kidney; not skeletal muscle |
SLC4A8 | NDCBE | kNBC3 | C, E | sodium bicarbonate chloride | brain, testes, kidney, ovary |
SLC4A9 | AE4 | inconclusive | at least kidney | ||
SLC4A10 | NBCn2 | NCBE | C, E | sodium bicarbonate chloride | brain |
SLC4A11 | BTR1 | NaBC1 | C | sodium, borate | kidney, salivary gland testis, thyroid, trachea |
[+] SLC5 Sodium glucose cotransporter family
References
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC5A1 | SGLT1 | None | C / Na+, (H+), F / Na+, (H+), Ch / urea, water | glucose and galactose (urea and water) | small intestine, trachea, kidney, heart, brain, testes, prostrate |
SLC5A2 | SGLT2 | None | C / Na+ | glucose | kidney, brain, liver, heart muscle, thyroid, salivary glands |
SLC5A3 | SMIT1 | None | C / Na+ | myoinositol (glucose) | brain, heart, kidney, lung |
SLC5A4 | SGLT3 | SAAT1 | glucose activated Na+, (H+) channel | Na+ (H+) | small intestine (cholinergic neurons), skeletal muscle, kidney, uterus, testis |
SLC5A5 | NIS | C / Na+, F / Na+, Ch / urea, water | I- (ClO4-, SCN-, NO3-, Br-) | thyroid, lactating breast, colon, stomach, ovary | |
SLC5A6 | SMVT | C / Na+ | biotin, lipoate panthothenate, I- | brain, heart, kidney, lung, placenta | |
SLC5A7 | CHT | CHT1 | choline | spinal cord, medulla | |
SLC5A8 | SMCT1 | AIT | C / Na+ | short chain fatty acids | small intestine, kidney, brain, retina, muscle |
SLC5A9 | SGLT4 | C / Na+ | mannose, fructose, glucose | kidney, small Intestine, brain, kidney, liver, heart, uterus, lung | |
SLC5A10 | SGLT5 | RK-D | C / Na+ | mannose, fructose, glucose | kidney cortex |
SLC5A11 | SMIT2 | SGLT6, KST1 | C / Na+ | myoinositol, chiro-inositol | thyroid, brain, heart, muscle, spleen, liver, lung |
SLC5A12 | SMCT2 | C / Na+ | short chain fatty acids | intestine, brain, retina, muscle |
[+] SLC6 Sodium- and chloride-dependent neurotransmitter transporter family
References
Original version of the SLC table:
Pramod AB, Foster J, Carvelli L, Henry LK. SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr;34(2-3):197-219.
Original version of the SLC table:
Pramod AB, Foster J, Carvelli L, Henry LK. SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr;34(2-3):197-219.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC6A1 | GAT1 | GABA | GABAergic neurons in brain (neocortex, hippocampus, cerebellum, basal ganglia, brain stem, olfactory bulb, glia), peripheral nervous system, retina | ||
SLC6A2 | NAT1, NET1, NET | norepinephrine | brain (non adrenergic neuronal somata, axons, dendrites), peripheral nervous system, adrenal gland (chromaffin cells), placenta | ||
SLC6A3 | DAT, DAT1 | dopamine | brain (dopaminergic neurons), gut | ||
SLC6A4 | 5-HTT, SERT | serotonin | brain, peripheral nervous system, placenta, epithelium cells, platelets | ||
SLC6A5 | GlyT2 | glycine | brain (glycinergic neurons, Golgi cells, brain stem, cerebellum), spinal cord | ||
SLC6A6 | TauT | taurine | brain, retina, liver, kidney, heart, spleen, pancreas, placenta, skeletal muscle, lung | ||
SLC6A7 | PROT | proline | brain (glutamatergic neurons, hippocampus) | ||
SLC6A8 | CRTR, CT1 | creatine | ubiquitous | ||
SLC6A9 | GlyT1 | glycine | brain, retina, liver, spleen, kidney, pancreas, uterus, stomach, lung, placenta, intestine | ||
SLC6A10 | CT2 | testis | |||
SLC6A10P | pseudogene | CT2 | |||
SLC6A11 | GAT-B, GAT-3 | GABA | brain (GABAergic neurons, glia) | ||
SLC6A12 | BGT1 | betaine, GABA | brain, kidney, liver, heart, skeletal muscle, placenta | ||
SLC6A13 | GAT2 | GABA | brain (meninges, ependyma, choroid plexus), retina, liver, kidney, lung | ||
SLC6A14 | ATB0+, beta-alanine carrier system | neutral, cationic amino acids | lung, trachea, salivary gland, mammary gland, stomach, pituitary gland, intestine, uterus, prostate, testis | ||
SLC6A15 | B0AT2, v7-3, NTT7-3 | large, neutral amino acids | brain (amygdala, putamen, corpus callosum), kidney | ||
SLC6A16 | NTT5 | unknown | testis, pancreas, prostate | ||
SLC6A17 | NTT4, XT1 | neutral amino acids | brain, heart, skeletal muscle | ||
SLC6A18 | B0AT3, XT2 | neutral amino acids | kidney (proximal tubule) | ||
SLC6A19 | B0AT1, HND | neutral amino acids | intestine (duodenum, jejunum, ileum), stomach, kidney, liver, prostate | ||
SLC6A20 | system IMINO, XT3, Xtrp3 | proline, pipecolate, sarcosine | brain, kidney, small intestine, thymus, spleen, ovary, lung | ||
SLC6A21 | pseudogene | SLC6A21 |
[+] SLC7 Cationic amino acid transporter/glycoprotein-associated family
References
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC7A1 | CAT-1 | ATRC1, system y+ | F (non-obligatory E) | cationic L-amino acids | ubiquitous except for liver, lacrimal gland |
SLC7A2 | CAT-2 (A or B) | ATRC2, system y+ | F | cationic L-amino acids | CAT-2A: liver, skeletal muscle, pancreas, CAT-2B: inducible in many cell types |
SLC7A3 | CAT-3 | ATRC3, system y+ | F | cationic L-amino acids | thymus, ovary, testis, brain (neurons) |
SLC7A4 | CAT-4 | O | brain, testis, placenta | ||
SLC7A5 | LAT1 | [4F2hc], 4F2lc, system L | E (similar intra- and extracellular selectivities, lower intracellular apparent affinity) | large neutral L-amino acids, T3, T4, L-DOPA, BCH | brain, ovary, testis, placenta, spleen, colon, blood-brain barrier, fetal liver, activated lymphocytes, tumor cells |
SLC7A5P1 | pseudogene | LAT1-3TM, MLAS | |||
SLC7A6 | y+LAT2 | [4F2hc], system y+L | E (preferentially intracellular cationic amino acid against extracellular neutral amino acid / Na+) | cationic amino acids (Na+ indep.), large neutral L-amino acids (Na+ dep.) | brain, small intestine, testis, parotids, heart, kidney, lung, thymus |
SLC7A7 | y+LAT1 | [4F2hc], system y+L | E (preferentially intracellular cationic amino acid against extracellular neutral amino acid / Na+) | cationic amino acids (Na+ indep.), large neutral L-amino acids (Na+ dep.) | small intestine, kidney, spleen, leucocytes, placenta, lung/ basolateral in epithelial cells |
SLC7A8 | LAT2 | [4F2hc], system L | E (similar intra- and extracellular selectivities, lower intracellular apparent affinity) | neutral L-amino acids, T3, T4, BCH | small intestine, kidney, lung, heart, spleen, liver, brain, placenta, prostate, ovary, fetal liver, testis, skeletal muscle |
SLC7A9 | b0,+AT | [rBAT], system b0,+ | E (preferentially extracellular cationic amino acid and cystine against intracellular neutral amino acid) | cationic amino acids, large neutral amino acids | kidney, small intestine, liver, placenta |
SLC7A10 | Asc-1 | [4F2hc], system asc | preferentially E | small neutral amino acids | brain, CNS, lung, small intestine, heart, placenta, skeletal muscle, kidney |
SLC7A11 | xCT | [4F2hc], system xc- | E (preferentially extracellular cystine against intracellular glutamate) | cystine (anionic form), L-glutamate | macrophages, brain, retinal pigment cells, liver, kidney |
SLC7A13 | AGT-1 | XAT2 | E | L-aspartate, L-glutamate | proximal straight tubules, distal convoluted tubules |
SLC7A14 | O | highly expressed in CNS | |||
SLC7A15P | pseudogene |
[+] SLC8 Na+/Ca2+ exchanger family
References
Original version of the SLC table:
Khananshvili D. The SLC8 gene family of sodium-calcium exchangers (NCX) - Structure, function, and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):220-35.
Original version of the SLC table:
Khananshvili D. The SLC8 gene family of sodium-calcium exchangers (NCX) - Structure, function, and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):220-35.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC8A1 | NCX1 | NACA, NCE | E / Na+, Ca2+ | Na+, Ca2+ | ubiquitous tissue distribution; specific splice variants found in brain, heart, kidney, pancreas |
SLC8A2 | NCX2 | E / Na+, Ca2+ | Na+, Ca2+ | abundant in neurons in all parts of the brain, but not present at significant levels elsewhere | |
SLC8A3 | NCX3 | E / Na+, Ca2+ | Na+, Ca2+ | expressed selectively in skeletal muscle, at lower levels in some brain regions | |
SLC8B1 | NCLX | mNCX | E / Na+, Li+, Ca2+ | Na+, Li+, Ca2+ | found in mitochondria of mammalian skeletal and heart muscle, neurons, β-cells and B-cells, liver contains relatively small amounts |
[+] SLC9 Na+/H+ exchanger family
References
Original version of the SLC table:
Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med. 2013 Apr;34(2-3):236-51.
Original version of the SLC table:
Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med. 2013 Apr;34(2-3):236-51.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC9A1 | NHE1 | APNH? | E / Na+, H+ | Na+, Li+, H+, NH4+ | Most mammalian cells, except macula densa and α- and β-intercalated cells of the kidney |
SLC9A2 | NHE2 | E / Na+, H+ | Na+, Li+, H+, NH4+ | Brush border of small intestine, colon, gallbladder, stomach, endothelial cells, kidney | |
SLC9A3 | NHE3 | E / Na+, H+ | Na+, Li+, H+, NH4+ | Small intestine, colon, gallbladder, renal proximal tubule, thick and thin limbs of the loop of Henle, gastric parietal cells, epididymis, ovary, thymus, prostate, medulla oblongata, pons | |
SLC9A3P1 | pseudogene | ||||
SLC9A3P2 | pseudogene | ||||
SLC9A3P3 | pseudogene | ||||
SLC9A3P4 | pseudogene | ||||
SLC9A4 | NHE4 | E / Na+, H+ | Na+, Li+ (?), H+, NH4+ | Stomach, kidney medulla, hippocampus, zymogen granule of pancreas, salivary gland | |
SLC9A5 | NHE5 | E / Na+, H+ | Na+, Li+, H+, NH4+ (?) | Brain | |
SLC9A6 | NHE6 | E / Na+ (K+), H+ | Na+, K+, H+ | Brain | |
SLC9A7 | NHE7 | E / Na+ (K+), H+ | Na+, K+, Li+, H+, NH4+ (?) | Most mammalian cells | |
SLC9A7P1 | pseudogene, partially processed | ||||
SLC9A8 | NHE8 | E / Na+ (K+), H+ | Na+, K+, H+ | Kidney, intestine | |
SLC9A9 | NHE9 | E / Na+ (K+), H+ | Na+, K+, H+ | Brain | |
SLC9B1 | NHA1 | NHEDC1 | Testis | ||
SLC9B2 | NHA2 | NHEDC2 | Na+, Li+ | Distal convoluted tubules of kidney, osteoclasts, β-cells of endocrine pancreas | |
SLC9C1 | Sperm-NHE | Na+, H+ | Spermatozoa | ||
SLC9C2 |
[+] SLC10 Sodium bile salt cotransport family
References
Original version of the SLC table:
Claro da Silva T, Polli JE, Swaan PW. The solute carrier family 10 (SLC10): Beyond bile acid transport. Mol Aspects Med. 2013 Apr;34(2-3):252-69.
Original version of the SLC table:
Claro da Silva T, Polli JE, Swaan PW. The solute carrier family 10 (SLC10): Beyond bile acid transport. Mol Aspects Med. 2013 Apr;34(2-3):252-69.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC10A1 | NTCP | LBAT | C / Na+ | bile acids | liver, pancreas |
SLC10A2 | ASBT | IBAT, ISBT, NTCP2 | C / Na+ | bile acids | ileum, kidney, biliary tract |
SLC10A3 | P3 | O | ubiquitous | ||
SLC10A4 | P4 | O | brain (cholinergic neurons), placenta, liver | ||
SLC10A5 | P5 | O | liver, kidney | ||
SLC10A6 | SOAT | P6 | C / Na+ | estrone-3-sulfate, dehydroepiandrosterone sulfate, pregnenolone sulfate | testis, placenta, pancreas |
SLC10A7 | P7 | C4orf13 | O | liver, testis |
[+] SLC11 Proton-coupled metal ion transporter family
References
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC11A1 | NRAMP1 | NRAMP, LSH | E or C ? / H+ | Mn2+, Fe2+, other divalent metal ions | phagolysosomes of phagocytes (macrophages, neutrophils) |
SLC11A2 | DMT1 | NRAMP2, DCT1 | C / H+ | Fe2+, Cd2+, Co2+, Cu1+, Mn2+, Ni2+, Pb2+, Zn2+ | widespread, including intestine (duodenum), erythroid cells, kidney, lung, brain, testis (Sertoli cells), thymus |
[+] SLC12 Electroneutral cation-coupled Cl cotransporter family
References
Original version of the SLC table:
Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Mol Aspects Med. 2013 Apr;34(2-3):288-98.
Original version of the SLC table:
Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Mol Aspects Med. 2013 Apr;34(2-3):288-98.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC12A1 | NKCC2 | Na+, K+, Cl- | kidney specific | ||
SLC12A2 | NKCC1 | Na+, K+, Cl- | ubiquitous | ||
SLC12A3 | NCC | Na+, Cl- | kidney, bone | ||
SLC12A4 | KCC1 | K+, Cl- | ubiquitous | ||
SLC12A5 | KCC2 | K+, Cl- | neurons | ||
SLC12A6 | KCC3 | K+, Cl- | extensive | ||
SLC12A7 | KCC4 | K+, Cl- | extensive, limited in brain | ||
SLC12A8 | CCC9 | unknown | extensive | ||
SLC12A9 | CIP | polyamines? | extensive |
[+] SLC13 Human Na+-sulfate/carboxylate cotransporter family
References
Original version of the SLC table:
Bergeron MJ, Clémençon B, Hediger MA, Markovich D. SLC13 family of Na(+)-coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr;34(2-3):299-312.
Original version of the SLC table:
Bergeron MJ, Clémençon B, Hediger MA, Markovich D. SLC13 family of Na(+)-coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr;34(2-3):299-312.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC13A1 | NaS1 | Na-sulfate, NaSi-1 | C / Na+ | sulfate, selenate, thiosulfate | kidney, proximal tubular cells |
SLC13A2 | NaC1 | SDCT1, NaDC-2, NaDC1 | C / Na+ | succinate, citrate, ?-ketoglutarate | kidney, intestine |
SLC13A3 | NaC3 | NaDC3, NaC3, SDCT2 | C / Na+ | succinate, citrate, ?-ketoglutarate, NALA, glutarate and its derivatives | kidney, proximal tubule, liver, pancreas, brain, placenta |
SLC13A4 | NaS2 | SUT1 | C / Na+ | sulfate, oxyanions selenium and chromium | placenta, tonsillar high endothelial venules, testis, heart |
SLC13A5 | NaC2 | NaCT | C / Na+ | citrate, succinate, pyruvate | liver, brain, testis |
[+] SLC14 Urea transporter family
References
Original version of the SLC table:
Shayakul C, Clémençon B, Hediger MA. The urea transporter family (SLC14): Physiological, pathological and structural aspects. Mol Aspects Med. 2013 Apr;34(2-3):313-22.
Original version of the SLC table:
Shayakul C, Clémençon B, Hediger MA. The urea transporter family (SLC14): Physiological, pathological and structural aspects. Mol Aspects Med. 2013 Apr;34(2-3):313-22.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC14A1_UT-B1 | UT3, UT11, JK, Kidd antigen | descending vasa recta, papillary epithelia, erythrocyte, bone marrow, urinary tract, bladder, small intestine, colon, brain, thymus, heart, lung, liver, spleen, pancreas, skeletal muscle, ear, prostate, testis (Sertoli cells) | |||
SLC14A1_UT-B2 | caudate nucleus (human), rumen (bovine), thymus (mouse) | ||||
SLC14A2_UT-A1 | UT1 | inner medullary collecting duct, cochlea | |||
SLC14A2_UT-A2 | UT2 | descending thin limb of Henle's loop, liver, heart | |||
SLC14A2_UT-A3 | UT4 | inner medullary collecting duct, cochlea | |||
SLC14A2_UT-A4 | renal medullab (rat) | ||||
SLC14A2_UT-A5 | testis (mouse) | ||||
SLC14A2_UT-A6 | colon (human) |
[+] SLC15 Proton oligopeptide cotransporter family
References
Original version of the SLC table:
Smith DE, Clémençon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med. 2013 Apr;34(2-3):323-36.
Original version of the SLC table:
Smith DE, Clémençon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med. 2013 Apr;34(2-3):323-36.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC15A1 | PEPT1 | oligopeptide transporter 1, H+-peptide transporter 1 | C / H+ | di- and tri-peptides, protons, beta-lactam antibiotics | small intestine, kidney, pancreas, bile duct, liver |
SLC15A2 | PEPT2 | oligopeptide transporter 2, H+-peptide transporter 2 | C / H+ | di- and tri-peptides, protons, beta-lactam antibiotics | apical surface of epithelial cells from kidney and choroid plexus; neurons, astrocytes (neonates), lung, mammary gland, spleen, enteric nervous system |
SLC15A3 | PHT2 | peptide/histidine transporter 2, PTR3 | C / H+ | di- and tri-peptides, protons, histidine | lung, spleen, thymus, intestine (faintly in brain, liver, adrenal gland, heart) |
SLC15A4 | PHT1 | peptide/histidine transporter 1, PTR4 | C / H+ | di- and tri-peptides, protons, histidine | brain, eye, intestine (faintly in lung and spleen) |
[+] SLC16 Monocarboxylate transporter family
References
Original version of the SLC table:
Halestrap AP. The SLC16 gene family - Structure, role and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):337-49.
Original version of the SLC table:
Halestrap AP. The SLC16 gene family - Structure, role and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):337-49.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC16A1 | MCT1, | MOT1 | C / H+ or E / monocarboxylate | lactate, pyruvate, ketone bodies | ubiquitous except beta cells of endocrine pancreas |
SLC16A2 | MCT8 | MOT8, XPCT, MCT7 | F | T2, rT3, T3, T4 | most tissues including liver, heart, brain, thymus, intestine, ovary, prostate, pancreas, placenta, lung kidney, skeletal muscle |
SLC16A3 | MCT4 | MOT4, MCT3 | C / H+ | lactate, ketone bodies | skeletal muscle, chondrocytes, leukocytes, testis, lung, ovary, placenta, heart |
SLC16A4 | MCT5 | MOT5, MCT4 | O | brain, muscle, liver, kidney, lung, ovary, placenta, heart | |
SLC16A5 | MCT6 | MOT6, MCT5 | bumetanide, probenecid, nateglinide ? | kidney, muscle, brain, heart, pancreas, prostate, lung, placenta | |
SLC16A6 | MCT7 | MOT7, MCT6 | O | brain, pancreas, muscle, prostate | |
SLC16A7 | MCT2 | MOT2 | C / H+ | pyruvate, lactate, ketone bodies | high expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain, leukocyte |
SLC16A8 | MCT3 | MOT3, REMP | C / H+ (pH dependent but cotransport not confirmed experimentally) | lactate | retinal pigment epithelium, choroid plexus |
SLC16A9 | MCT9 | MOT9 | O | endometrium, testis, ovary, breast, brain, kidney, spleen adrenal, retina | |
SLC16A10 | TAT1, MCT10 | MOT10 | F | aromatic amino acids, T3, T4 | kidney, intestine, muscle, placenta, heart |
SLC16A11 | MCT11 | MOT11 | O | skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, choroid plexus | |
SLC16A12 | MCT12 | MOT12 | O | kidney, retina, lung testis | |
SLC16A13 | MCT13 | MOT13 | O | breast, bone marrow stem cells | |
SLC16A14 | MCT14 | MOT14 | O | brain, heart, muscle, ovary, prostate, breast, lung, pancreas liver, spleen, thymus |
[+] SLC17 Vesicular glutamate transporter family
References
Original version of the SLC table:
Reimer RJ. SLC17: A functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr;34(2-3):350-9.
Original version of the SLC table:
Reimer RJ. SLC17: A functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr;34(2-3):350-9.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC17A1 | NPT1 | NaPi1 | electrogenic, Cl- dependent; C/Na+; channel | organic anions, phosphate, chloride | kidney, liver |
SLC17A2 | NPT3 | unknown | unknown | heart, muscle, brain, placenta, lung, liver kidney, pancreas | |
SLC17A3 | NPT4 | electrogenic | organic anions | liver, kidney, small intestine, testis | |
SLC17A4 | Na+/PO4-cotransporter homologue | unknown | unknown | small intestine, colon, liver, pancreas | |
SLC17A5 | sialin | AST, VEAT | C / H+ | sialic acid, other acidic sugars | ubiquitous |
SLC17A6 | VGLUT2 | DNPI | electrogenic, Cl- dependent | glutamate | brain (neurons only), endocrine |
SLC17A7 | VGLUT1 | BNPI | electrogenic, Cl- dependent | glutamate | brain (neurons only), endocrine |
SLC17A8 | VGLUT3 | electrogenic, Cl- dependent | glutamate | brain (neurons, glia), liver, kidney | |
SLC17A9 | VNUT | electrogenic, Cl- dependent | purine nucleotides | brain (neurons), adrenal, thyroid |
[+] SLC18 Vesicular amine transporter family
References
Original version of the SLC table:
Lawal HO, Krantz DE. SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr;34(2-3):360-72.
Original version of the SLC table:
Lawal HO, Krantz DE. SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr;34(2-3):360-72.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC18A1 | VMAT1 | CGAT, VAT | E / H+ | 5-HT, DA, NE, epinephrine | sympathetic ganglia, some GI neurons, adrenal medulla |
SLC18A2 | VMAT2 | SVAT, SVMT, VAT2, MAT | E / H+ | 5-HT, DA, NE, epinephrine, histamine | all CNS aminergic neurons, mast cells, platelets, some GI neurons, adrenal medulla |
SLC18A3 | VAChT | Unc-17, Vesamicol binding protein | E / H+ | acetylcholine | cholinergic neurons, pancreatic stellate cells, tracheal brush cells |
SLC18B1 | C6orf192 | hypothetical human protein LOC116843, dJ55C23.6 gene product | unknown | unknown | broad, including brain, lung |
[+] SLC19 Folate/thiamine transporter family
References
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC19A1 | RFC | RFC1, RFT | E / organic phosphates | reduced folates, antifolates | ubiquitous |
SLC19A2 | THTR1 | ThTr1 | F | thiamine | ubiquitous |
SLC19A3 | THTR2 | ThTr2 | F | thiamine | ubiquitous |
[+] SLC20 Type III Na+-phosphate cotransporter family
References
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC20A1 | PiT-1 | gibbon ape leukemia virus receptor 1, GLVR1, Glvr1, FLJ41426, DKFZp686J2397 | C / Na+, H2PO4- | inorganic phosphate (monovalent) | widely expressed |
SLC20A2 | PiT-2 | amphotropic murine leukemia virus receptor 2, GLVR2, Glvr-2, MLVAR | C / Na+, H2PO4- | inorganic phosphate (monovalent) | widely expressed, kidney (proximal tubule) |
[+] SLC21 Organic anion transporter family
References
Original version of the SLC table:
Hagenbuch B, Stieger B. The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med. 2013 Apr;34(2-3):396-412.
Original version of the SLC table:
Hagenbuch B, Stieger B. The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med. 2013 Apr;34(2-3):396-412.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLCO2A1 | OATP2A1 | prostaglandins (C/lactate) | ubiquitous | ||
SLCO4A1 | OATP-E, OATP4A1 | ||||
SLCO5A1 | OATPRP4, OATP-J, OATP5A1 | ||||
SLCO3A1 | OATP-D, OATP3A1 | ||||
SLCO6A1 | OATP6A1, OATPY, MGC26949, CT48 | ||||
SLCO1A2 | OATP1A2 | bile salts, organic anions and cations | brain (endothelial cells), kidney, intestine, liver (cholangiocytes), eye (ciliary body) | ||
SLCO2B1 | OATP2B1 | E-3-S, DHEAS | liver (hepatocytes), placenta, intestine, eye | ||
SLCO1B1 | OATP1B1 | bile salts, organic anions | liver (hepatocytes) | ||
SLCO1B3 | OATP1B3 | bile salts, organic anions | liver (hepatocytes) | ||
SLCO4C1 | SLC21A20, OATP4C1, OATPX, OATP-H | ||||
SLCO1C1 | OATP1C1 | T4, T3, rT3 | brain (blood-brain barrier), testis (Leydig cells) |
[+] SLC22 Organic cation/anion/zwitterion transporter family
References
Original version of the SLC table:
Koepsell H. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med. 2013 Apr;34(2-3):413-35.
Original version of the SLC table:
Koepsell H. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med. 2013 Apr;34(2-3):413-35.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC22A1 | OCT1 | F | organic cations | liver, small intestine, kidney, lung, skeletal muscle, brain (endothelial cells of blood-brain barrier), adipose tissue, immune cells | |
SLC22A2 | OCT2 | F | organic cations | kidney, small intestine, lung, placenta, thymus, brain (neurons, blood-brain barrier), inner ear | |
SLC22A3 | OCT2 | EMT (uptake-2 system) | F | organic cations | heart, skeletal muscle, brain (neurons, glial cells, plexus choroideus), small intestine, liver, lung, kidney, urinary bladder, mammary gland, skin blood vessels |
SLC22A4 | OCTN1 | ETT | C / Na+ | ergothioneine, zwitterions, organic cations | kidney, intestine, spleen, heart, skeletal muscle, brain, mammary gland, thymus, prostate, airways, testis, eye, fetal liver, sperm, immune cells |
SLC22A5 | OCTN2 | CT1, CDSP | C / Na+, L-carnitine, F / organic cations | zwitterions (L-carnitine), organic cations | skeletal muscle, kidney, prostate, lung, pancreas, heart, small intestine, adrenal gland, thyroid gland, liver, etc. |
SLC22A6 | OAT1 | PAHT, NKT | E / organic anions | organic anions | kidney, placenta, brain |
SLC22A7 | OAT2 | NLT | F or E | organic anions | liver, kidney |
SLC22A8 | OAT3 | E / dicarboxylate | organic anions | kidney, brain, skeletal muscle, developing bone | |
SLC22A9 | OAT7 | UST3, OAT4 | E / short chain fatty acids | organic anions | liver |
SLC22A10 | OAT5 | O | not determined | liver | |
SLC22A11 | OAT4 | F or E | organic anions | kidney, placenta | |
SLC22A12 | URAT1 | RST, OAT4L | E / organic anions | urate, organic anions | kidney |
SLC22A13 | OAT10 | ORCTL3, OCTL1 | E / anions | urate, organic anions | kidney, colon, small intestine, brain, heart |
SLC22A14 | OCTL2 | ORCTL4 | O | not determined | kidney, colon, small intestine |
SLC22A15 | FLIPT1 | O | not determined | kidney, brain, liver, skeletal muscle, heart, placenta, lung, spleen | |
SLC22A16 | 39726 | FLIPT2, CT2 | F | L-carnitine, noncharged compounds | testis (Sertoli cells and epididymal duct cells), bone marrow, leukocytes, kidney |
SLC22A17 | BOIT | BOCT, NGALR | O | not determined | brain |
SLC22A18 | IMPT1, TSSC5, ORCTL2 | probably organic anions | kidney | ||
SLC22A20 | OAT6 | E / dicarboxylate | probably organic anions | olfactory mucosa | |
SLC22A23 | O | ||||
SLC22A24 | O | ||||
SLC22A25 | UST6 | HIMTP | O | liver | |
SLC22A31 | larynx, prostate, pancreas, embryonic tissue | ||||
SLC22A32 | MFSD10 | TETRAN | C / H+ | p-aminohippuric acid (PAH), indomethacin, diclofenac, mefenamic acid, etodolac [PMID: 18638446] | Heart, kidney (luminal membrane of proximal tubules), prostate [PMID: 18638446] |
SLC22B1 | SV2A | Galactose [PMID: 25326386]; also binds levetiracetam [PMID: 15210974], selectracetam [PMID: 18183537], brivaracetam [PMID: 17785672]. | Brain, highest levels in subcortex (basal ganglia, thalamus) [PMID: 7681585] | ||
SLC22B2 | SV2B | Brain, highest levels in hippocampus and cortex [PMID: 7681585] | |||
SLC22B3 | SV2C | Striatum, substantia nigra, pons/medulla oblongata [PMID: 10625067]; olfactory bulb [PMID: 10625067] | |||
SLC22B4 | SVOP | Nicotinate [PMID: 21953179]; binds nucleotides in the TM region [PMID: 19390693] | Brain [PMID: 9801366] | ||
SLC22B5 | SVOPL | Brain, liver, kidney, skeletal muscle, epididymis, testis, ovary, thymus, spinal cord [PMID: 17714910] |
[+] SLC23 Na+-dependent ascorbic acid transporter family
References
Original version of the SLC table:
Bürzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clémençon B, Burrier R, Hediger MA. The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med. 2013 Apr;34(2-3):436-54.
Original version of the SLC table:
Bürzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clémençon B, Burrier R, Hediger MA. The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med. 2013 Apr;34(2-3):436-54.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC23A1 | SVCT1 | YSPL3, NCBT2, MGC22361 | C / Na+ | L-ascorbic acid | epithelial tissues including kidney, intestines, liver, lung, skin |
SLC23A2 | SVCT2 | YSPL2, KIAA0238, NBTL1, NCBT1 | C / Na+ | L-ascorbic acid | widespread including brain (neurons), retina, placenta, spleen, prostate, testis, ovary (rat Svct2 also in lung, adrenal, osteoblast) |
SLC23A3 | SVCT3 | YSPL1, FLJ31168, E2BP3 | |||
SLC23A4P | SVCT4 |
[+] SLC24 Na+/(Ca2+-K+) exchanger family
References
Original version of the SLC table:
Schnetkamp PP. The SLC24 gene family of Na(+)/Ca(2+)-K(+) exchangers: From sight and smell to memory consolidation and skin pigmentation. Mol Aspects Med. 2013 Apr;34(2-3):455-64.
Original version of the SLC table:
Schnetkamp PP. The SLC24 gene family of Na(+)/Ca(2+)-K(+) exchangers: From sight and smell to memory consolidation and skin pigmentation. Mol Aspects Med. 2013 Apr;34(2-3):455-64.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC24A1 | NCKX1 | RODX, HsT17412, KIAA0702 | E / 4 Na+, Ca2+, K+ | Na+, Ca2+, K+ | rod photoreceptors, platelets |
SLC24A2 | NCKX2 | E / 4 Na+, Ca2+, K+ | Na+, Ca2+, K+ | brain, retinal cone, photoreceptors, retinal, ganglion cells | |
SLC24A3 | NCKX3 | E / 4 Na+, Ca2+, K+ | Na+, Ca2+, K+ | brain, aorta, uterus, intestine | |
SLC24A4 | NCKX4 | SHEP6, FLJ38852 | E / 4 Na+, Ca2+, K+ | Na+, Ca2+, K+ | brain, olfactory neurons, aorta, lung, thymus |
SLC24A5 | NCKX5 | JSX, SHEP4 | E / 4 Na+, Ca2+, K+ | Na+, Ca2+, K+ | retina, brain, thymus, skin |
[+] SLC25 Mitochondrial carrier family
References
Original version of the SLC table:
Palmieri F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Mol Aspects Med. 2013 Apr;34(2-3):465-84.
Original version of the SLC table:
Palmieri F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Mol Aspects Med. 2013 Apr;34(2-3):465-84.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC25A1 | CIC (citrate carrier) | CTP, tricarboxylate carrier, SLC20A3 | E / citrate-H+, malate | citrate, isocitrate, malate, PEP | liver, kidney, pancreas, also in brain, lung, heart |
SLC25A2 | ORC2 (ornithine carrier 2) | ORNT2 | E / ornithine, citrulline, H+; ornithine, H+ | ornithine, citrulline, lysine, arginine, histidine | liver, testis, spleen, lung, pancreas, small intestine, brain, kidney |
SLC25A3 | PHC (phosphate carrier) | PTP, PiC | C / phosphate, H+; E / phosphate, OH- | phosphate | isoform A: heart, skeletal muscle, diaphragm; isoform B: liver, kidney, brain, thymus, lung, heart, skeletal muscle, diaphragm |
SLC25A4 | ANT1 (adenine nucleotide translocase-1) | AAC1, T1, PEO2, PEO3 | E / ADP, ATP | ADP, ATP | heart, skeletal muscle, much less in brain, pancreas, prostate, kidney, lung, thymus |
SLC25A5 | ANT2 (adenine nucleotide translocase-2) | AAC2, T2 | E / ADP, ATP | ADP, ATP | brain, lung, kidney, pancreas, heart, skeletal muscle, spleen |
SLC25A5P1 | pseudogene | bK250D10, ANTP3 | |||
SLC25A6 | ANT3 (adenine nucleotide translocase-3) | AAC3, T3 | E / ADP, ATP | ADP, ATP | brain, lung, kidney, liver, pancreas, heart, skeletal muscle, spleen, thymus |
SLC25A6P1 | pseudogene | ||||
SLC25A7 | UCP1 (uncoupling protein 1) | thermogenin, proton carrier | F | H+ | brown adipose tissue |
SLC25A8 | UCP2 (uncoupling protein 2) | proton carrier, UCPH | F | H+ | lung, kidney, spleen, heart |
SLC25A9 | UCP3 (uncoupling protein 3) | proton carrier | F | H+ | skeletal muscle, lung |
SLC25A10 | DIC (dicarboxylate carrier) | E / malate, phosphate | malate, phosphate, succinate, sulphate, thiosulphate | liver, kidney, heart, brain, lung, pancreas | |
SLC25A11 | OGC (oxoglutarate carrier) | oxoglutarate / malate carrier, SLC20A4 | E / oxoglutarate, malate | 2-oxoglutarate, malate | heart, skeletal muscle, liver, kidney, brain, pancreas |
SLC25A12 | AGC1 (aspartate / glutamate carrier 1) | aralar1 | E / aspartate, glutamate, H+ | aspartate, glutamate | brain, heart, skeletal muscle, lung, pancreas, kidney, but not in liver |
SLC25A13 | AGC2 (aspartate / glutamate carrier 2) | citrin, CTLN2, aralar2 | E / aspartate, glutamate, H+ | aspartate, glutamate | liver, kidney, pancreas, heart, skeletal muscle, brain |
SLC25A14 | UCP5 (uncoupling protein 5) | BMCP1, brain mitochondrial carrier protein | O | widely expressed, with highest levels in brain and testis | |
SLC25A15 | ORC1 (ornithine carrier 1) | ORNT1, HHH | E / ornithine, citrulline, H+; ornithine, H+ | ornithine, citrulline, lysine, arginine | liver, pancreas, lung, testis, small intestine, spleen, kidney, brain, heart |
SLC25A15P1 | pseudogene | ||||
SLC25A16 | GDC (Graves' disease carrier) | GDA, ML7, HGT.1 | O | liver, kidney, thyroid, lung, heart, skeletal muscle, brain | |
SLC25A17 | PMP34, ANC1, ANT1 | E / CoA; PAP, CoA, dPCoA; CoA,AMP; FAD, FMN; NAD+, AMP | CoA, FAD, NAD+, AMP, ADP, PAP, dPCoA, FMN | brain, kidney, lung, heart, liver, pancreas | |
SLC25A18 | GC2 (glutamate carrier 2) | C / glutamate, H+; E / glutamate, OH- | glutamate | brain, testis, heart, pancreas, kidney, lung | |
SLC25A19 | DNC (deoxynucleotide carrier) | MUP1, TPC, MCPHA | E / thiamine pyrophosphate, thiamine monophosphate, thiamine; pyrophosphate, (deoxy)nucleotide | thiamine pyrophosphate, thiamine monophosphate, (deoxy)nucleotides | brain, testis, lung, kidney, liver, spleen, skeletal muscle, heart |
SLC25A20 | CAC (carnitine / acylcarnitine carrier) | CACT, carnitine carrier | E / carnitine, acylcarnitine; F (at slow rate) | carnitine, acylcarnitine | heart, skeletal muscle, liver, also in lung, kidney, brain, pancreas, lung, placenta |
SLC25A20P1 | pseudogene | ||||
SLC25A21 | ODC (oxoadipate carrier) | E / oxoadipate, oxoglutarate | oxoadipate, oxoglutarate | kidney, gall bladder, colon, liver, placenta, testis, lung, spleen, skeletal muscle, brain, heart | |
SLC25A22 | GC1 (glutamate carrier 1) | C / glutamate, H+; E / glutamate, OH- | glutamate | pancreas, brain, liver, testis, spleen, kidney, heart, lung, small intestine, pancreatic beta cells | |
SLC25A23 | APC2 | ScaMC-3, MCSC2 | E / ATP-Mg, Pi | ATP-Mg2+, ATP, ADP, AMP, Pi | kidney, lung, small intestine, pancreas, brain, liver, skeletal muscle, heart |
SLC25A24 | APC1 | ScaMC-1 | E / ATP-Mg, Pi | ATP-Mg2+, ATP, ADP, AMP, Pi | testis |
SLC25A25 | APC3 | ScaMC-2, MCSC, PCSCL | O | brain, heart, skeletal muscle, liver, small intestine, lung, pancreas, testis | |
SLC25A26 | SAMC | E / S-adenosyl-methionine, S-adenosyl-homocysteine | S-adenosyl-methionine, S-adenosyl-homocysteine | ubiquitous (testis) | |
SLC25A27 | UCP4 (uncoupling protein 4) | O | brain | ||
SLC25A28 | Mitoferrin 2 (Mfrn2) | MRS3 / 4, MRS4L | Fe2+ | ubiquitous (heart, liver, kidney) | |
SLC25A29 | ORNT3 | CACL | ornithine, acylcarnitine | heart, skeletal muscle, liver, brain | |
SLC25A30 | KMCP1, UCP6 | O | kidney | ||
SLC25A31 | AAC4, ANT4 (adenine nucleotide carrier 4) | SFEC | E / ADP, ATP | ADP, ATP | testis |
SLC25A32 | MFT | MFTC | folate | ||
SLC25A33 | PNC1 (pyrimidine nucleotide carrier 1) | BMSC-MCP | UTP | ubiquitous | |
SLC25A34 | O | ||||
SLC25A35 | O | ||||
SLC25A36 | PNC2 (pyrimidine nucleotide carrier 2) | pyrimidine nucleotides | |||
SLC25A37 | Mitoferrin 1 (Mfrn1) | HT015, MSC, MSCP | Fe2+ | fetal liver, bone marrow, spleen, placenta, liver, brain | |
SLC25A38 | glycine ? | erythroid cells | |||
SLC25A39 | CGI-69 | O | ubiquitous | ||
SLC25A40 | MCFP | O | ubiquitous at low levels | ||
SLC25A41 | APC4 | SCaMC-3L | E | ATP-Mg / Pi | brain, testis, liver |
SLC25A42 | E | CoA, ADP, ATP, adenosine 3',5'-diphosphate, dPCoA | ubiquitous (adipose tissue) | ||
SLC25A43 | O | brain, adrenal gland, skeletal muscle | |||
SLC25A44 | O | ubiquitous | |||
SLC25A45 | O | skeletal muscle, intestine, brain, testis | |||
SLC25A46 | O | ubiquitous | |||
SLC25A47 | C14orf68, HDMCP | O | |||
SLC25A48 | FLJ44862 | O | |||
SLC25A49 | MTCH1 | MCH1 | O | ||
SLC25A50 | MTCH2 | MCH2 | O | ||
SLC25A51 | MCART1 | MCTR1 | O | ||
SLC25A51P1 | pseudogene | MCART3P | |||
SLC25A51P2 | pseudogene | MCART4P | |||
SLC25A51P3 | pseudogene | MCART5P | |||
SLC25A52 | MCART2 | MCTR2 | O | ||
SLC25A53 | MCART6 | MCTR6 | O |
[+] SLC26 Multifunctional anion exchanger family
References
Original version of the SLC table:
Alper SL, Sharma AK. The SLC26 gene family of anion transporters and channels. Mol Aspects Med. 2013 Apr;34(2-3):494-515.
Original version of the SLC table:
Alper SL, Sharma AK. The SLC26 gene family of anion transporters and channels. Mol Aspects Med. 2013 Apr;34(2-3):494-515.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC26A1 | SAT1, SLC26A1 | E / SO42-, oxalate, glyoxylate | SO42-, oxalate, glyoxylate | hepatocytes, renal prox tubule, intestine | |
SLC26A2 | DTDST, SLC26A2 | E / SO42-, oxalate, Cl- | SO42-, oxalate, Cl- | chondrocytes, renal prox tubule, intestine, panc duct | |
SLC26A3 | DRA, CLD, SLC26A3 | E / Cl-, HCO3-, oxalate | Cl-, HCO3-, oxalate | enterocytes, sperrm, epididymis | |
SLC26A4 | PDS, Pendrin, SLC26A4 | E / I-, Cl-, HCO3- | I-, Cl-, HCO3- | cochlear, vestibular, epithelial cells, thyrocytes, type B intercalated cell, airway epithelial cell | |
SLC26A5 | Prestin, SLC26A5 | E / Cl-, formate, oxalate, SO42- | Cl-, formate, oxalate, SO42- | cochlear hair cells | |
SLC26A6 | CFEX, PAT1, SLC26A6 | E / Cl-, HCO3-, oxalate, OH-, formate | Cl-, HCO3-, oxalate, OH-, formate | enterocytes, pancreatic duct, renal prox tubule, cardiac myocytes, sperm | |
SLC26A7 | SUT2, SLC26A7 | E / Cl-, HCO3-, OH-, SO42-, Ch / Cl- | Cl-, HCO3-, OH-, SO42-, Ch: Cl- | gastric parietal cells, type A intercalated cells, endothelial cells | |
SLC26A8 | TAT1, SLC26A8 | E / Cl-, HCO3-, OH- | Cl-, HCO3-, OH- | male germ cells, sperm | |
SLC26A9 | SLC26A9 | E / Cl-, HCO3, Ch / Cl-, HCO3- | Cl-, HCO3, Ch: Cl-, HCO3- | airway epithelial cells, gastric parietal cells, kidney (cell type ?), brain | |
SLC26A10 | (SLC26A10) | widespread (transcribed ?, pseudogene ) | |||
SLC26A11 | SUT1, KBAT, SLC26A11 | E / Cl-, HCO3-, SO42-, oxalate, ?Ch / Cl- | Cl-, HCO3-, SO42-, oxalate (?), Ch: Cl- | renal intercalated cells, panc duct, endothelial cells, brain, widespread |
[+] SLC27 Fatty acid transporter family
References
Original version of the SLC table:
Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Mol Aspects Med. 2013 Apr;34(2-3):516-28.
Original version of the SLC table:
Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Mol Aspects Med. 2013 Apr;34(2-3):516-28.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC27A1 | FATP1 | FATP, ACSVL5 | LCFA transport, VLCFA activation | LCFA, VLCFA | BAT, WAT, heart, skeletal muscle, skin, brain, kidney, endothelial cells |
SLC27A2 | FATP2 | ACSVL1, VLCS, VLACS, FACVL1 | LCFA transport, VLCFA activation | LCFA, VLCFA | liver, kidney cortex, placenta |
SLC27A3 | FATP3 | ACSVL3, VLCS-3 | LCFA transport, VLCFA activation | LCFA, VLCFA | skin, adrenal gland, testis, ovary, brain, lung, endothelial cells |
SLC27A4 | FATP4 | ACSVL4 | LCFA transport, VLCFA activation | LCFA, VLCFA | small intestine, skin, placenta, brain, skeletal muscle, WAT, endothelial cells |
SLC27A5 | FATP5 | ACSVL6, VLCS-H2, VLACSR, FACVL3, BAL, ACSB, BACS | LCFA transport, bile acid conjugation | LCFA, bile acids | liver |
SLC27A6 | FATP6 | ACSVL2, VLCS-H1, FACVL2 | LCFA transport, VLCFA activation | LCFA, VLCFA | heart, skin |
[+] SLC28 Na+-coupled nucleoside transport family
References
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC28A1 | CNT1 | concentrative 1:1 sodium:nucleoside | kidney, liver, small intestine | ||
SLC28A2 | CNT2 | concentrative 1:1 sodium:nucleoside | heart, skeletal muscle, liver, kidney, intestine, pancreas, placenta, brain | ||
SLC28A3 | CNT3 | concentrative 2:1 sodium: nucleoside 1:1 proton: nucleoside probably 1:1:1 sodium:proton:nucleoside | widely expressed, most abundant in mammary gland, pancreas, bone marrow, trachea, intestine |
[+] SLC29 Facilitative nucleoside transporter family
References
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC29A1 | ENT1 | F | widely expressed | ||
SLC29A2 | ENT2 | F | particularly abundant in skeletal muscle but widely expressed | ||
SLC29A3 | ENT3 | unclear, possibly proton-linked | widely expressed | ||
SLC29A4 | ENT4 | unclear, possibly proton-linked | heart, brain, skeletal muscle |
[+] SLC30 Zinc efflux family
References
Original version of the SLC table:
Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - A review of current understanding of their biological and pathophysiological roles. Mol Aspects Med. 2013 Apr;34(2-3):548-60.
Original version of the SLC table:
Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - A review of current understanding of their biological and pathophysiological roles. Mol Aspects Med. 2013 Apr;34(2-3):548-60.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC30A1 | ZnT1 | widespread | |||
SLC30A2 | ZnT2 | mammary gland, prostate, retina, pancreas, small intestine, kidney | |||
SLC30A3 | ZnT3 | brain, testes, pancreas | |||
SLC30A4 | ZnT4 | widespread, predominant in mammary gland, placenta, prostate, brain, kidney | |||
SLC30A5 | ZnT5 | widespread, predominant in heart, placenta, pancreas, prostate, ovary, testis, small intestine, thymus, bone | |||
SLC30A6 | ZnT6 | widespread, predominant in brain, lung, intestine | |||
SLC30A7 | ZnT7 | widespread, predominant intestine, stomach, prostate, retina, pancreas, testis, muscle | |||
SLC30A8 | ZnT8 | pancreas, thyroid, adrenal gland, testis | |||
SLC30A9 | ZnT9 | widespread | |||
SLC30A10 | ZnT10 | brain, retina, liver |
[+] SLC31 Copper transporter family
References
Original version of the SLC table:
Kim H, Wu X, Lee J. SLC31 (CTR) family of copper transporters in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):561-70.
Original version of the SLC table:
Kim H, Wu X, Lee J. SLC31 (CTR) family of copper transporters in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):561-70.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC31A1 | CTR1 | hCtr1, Ctr1, COPT1 | energy in-dependent, potassium-dependent | copper (I), cisplatin | ubiquitous mRNA expression, highest in the liver, lowest in the brain, skeletal muscle |
SLC31A1P1 | pseudogene | SLC31A1P, CTR1psi, CTR1P | |||
SLC31A2 | CTR2 | hCtr2, Ctr2, COPT2 | unknown | copper, cisplatin | ubiquitous mRNA expression |
[+] SLC32 Vesicular inhibitory amino acid transporter family
References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC32A1 | VIAAT | VGAT | E / H+ | GABA / glycine | CNS |
[+] SLC33 Acetyl-CoA transporter family
References
Original version of the SLC table:
Hirabayashi Y, Nomura KH, Nomura K. The acetyl-CoA transporter family SLC33. Mol Aspects Med. 2013 Apr;34(2-3):586-9.
Original version of the SLC table:
Hirabayashi Y, Nomura KH, Nomura K. The acetyl-CoA transporter family SLC33. Mol Aspects Med. 2013 Apr;34(2-3):586-9.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC33A1 | ACATN1 | AT-1 | F | acetyl-CoA | brain, spinal cord, prostate, placenta, uterus, testis, thymus, trachea |
SLC33A2 | MFSD3 | Neurons [PMID: 27981419] |
[+] SLC34 Type II Na+-phosphate cotransporter family
References
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC34A1 | NaPi-IIa | Napi-3, NPT2, npt2 | C / Na, HPO42- | inorganic phosphate (divalent) | kidney (proximal tubule), osteoclasts, neurons |
SLC34A2 | NaPi-IIb | C / Na, HPO42- | inorganic phosphate (divalent) | small intestine, lung, testis, liver, secreting mammary gland | |
SLC34A3 | NaPi-IIc | C / Na, HPO42- | inorganic phosphate (divalent) | kidney (proximal tubule) |
[+] SLC35 Nucleoside-sugar transporter family
References
Original version of the SLC table:
Song Z. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):590-600.
Original version of the SLC table:
Song Z. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):590-600.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC35A1 | CST | CMPST | E / CMP | CMP-sialic acid | ubiquitous |
SLC35A2 | UGT | UGAT, UGTL, UGALT, UGT1, UGT2 | E / UMP | UDP-galactose, UDP-N-acetylgalactosamine | ubiquitous |
SLC35A3 | DKFZp781P1297 | E / UMP | UDP-N-acetylglucosamine | ubiquitous | |
SLC35A4 | MGC2541 | ubiquitous | |||
SLC35A5 | FLJ11130, FLJ20730, FLJ25973, DKFZp434E102 | ubiquitous | |||
SLC35B1 | UGTREL1 | ubiquitous | |||
SLC35B2 | PAPST1 | UGTrel4, SLL | PAPS | ubiquitous | |
SLC35B3 | PAPST2 | CGI-19, C6orf196 | PAPS | ubiquitous | |
SLC35B4 | YEA | YEA4, FLJ14697 | UDP-xylose, UDP-N-acetylglucosamine | ubiquitous | |
SLC35C1 | FUCT1 | FLJ11320, FLJ14841 | E / GMP | GDP-fucose | ubiquitous |
SLC35C2 | OVCOV1 | CGI-15, C20orf5, FLJ37039, FLJ46434, MGC20633, MGC32079, MGC39183, BA394O2.1 | GDP-fucose (?) | ubiquitous | |
SLC35D1 | UGTREL7 | KIAA0260, MGC138236 | E / UMP | UDP-glucuronic acid, UDP-N-acetylgalactosamine | ubiquitous, high in colon, stomach, lung, leukocytes |
SLC35D2 | HFRC1 | UGTrel8, Hfrc, SQV7L, MGC117215, MGC142139 | UDP-N-acetylglucosamine | ubiquitous, high in colon, stomach, lung, leukocytes | |
SLC35D3 | FRCL1 | MGC102873, bA55K22.3 | retina | ||
SLC35D4 | TMEM241 | C18orf45 | |||
SLC35E1 | FLJ14251, FLJ36689, MGC44954, DKFZp564G0462 | ubiquitous | |||
SLC35E2A | pseudogene | FLJ34996, FLJ44537, KIAA0447, MGC104754, MGC117254, MGC126715, MGC138494, DKFZp686M0869 | |||
SLC35E2B | N/D | N/D | N/D | ||
SLC35E3 | BLOV1 | ubiquitous | |||
SLC35E4 | MGC129826 | ubiquitous | |||
SLC35F1 | C6orf169, FLJ13018, dJ230I3.1 | brain | |||
SLC35F2 | HSNOV1, FLJ13018, DKFZp667H1615 | salivary gland | |||
SLC35F3 | FLJ37712 | cerebellum | |||
SLC35F4 | C14orf36, FLJ37712, c14_5373 | cerebellum | |||
SLC35F5 | FLJ22004 | ubiquitous | |||
SLC35F6 | C2orf18 | ANT2BP | |||
SLC35G1 | TMEM20, C10orf60 | ||||
SLC35G2 | TMEM22 | ||||
SLC35G3 | AMAC1, TMEM21A | ||||
SLC35G4 | AMAC1L1 | ||||
SLC35G5 | AMAC, AMAC1L2 | ||||
SLC35G6 | AMAC1L3, TMEM21B |
[+] SLC36 Proton-coupled amino acid transporter family
References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC36A1 | PAT1 | LYAAT1 | C / H+ | GABA, P, G, beta-alanine | brain, intestine, colon, kidney, lung, liver, spleen |
SLC36A2 | PAT2 | tamodorin 1 | C / H+ | P, G, A, hydroxyproline | lung, heart, kidney, muscle, testis, spleen, adrenal gland, thymus, sciatic nerve |
SLC36A3 | PAT3 | testes | |||
SLC36A4 | PAT4 | LYAAT2 | C / H+ | P, tryptophan | ubiquitous |
[+] SLC37 Sugar-phosphate/phosphate exchanger family
References
Original version of the SLC table:
Chou JY, Sik Jun H, Mansfield BC. The SLC37 family of phosphate-linked sugar phosphate antiporters. Mol Aspects Med. 2013 Apr;34(2-3):601-11.
Original version of the SLC table:
Chou JY, Sik Jun H, Mansfield BC. The SLC37 family of phosphate-linked sugar phosphate antiporters. Mol Aspects Med. 2013 Apr;34(2-3):601-11.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC37A1 | SLC37A1, SPX1 | glucose-6-phosphate | E / inorganic phosphate | ubiquitous, high levels in prostate, pancreas, thymus, bone marrow, spleen | |
SLC37A2 | SLC37A2, SPX2 | glucose-6-phosphate | E / inorganic phosphate | ubiquitous, high levels in spleen, thymus, bone marrow, prostate, lung, pancreas, liver, kidney, macrophages | |
SLC37A3 | SLC37A3, SPX3 | unknown | ubiquitous, high levels in spleen, thymus, bone marrow, lung, brain, prostate, pancreas | ||
SLC37A4 | SLC37A4, G6PT, SPX4 | glucose-6-phosphate | E / inorganic phosphate | ubiquitous, high levels in liver, kidney, prostate, pancreas, thymus, bone marrow, spleen |
[+] SLC38 System A and System N sodium-coupled neutral amino acid transporter family
References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC38A1 | SNAT1 | ATA1, NAT2, SAT1 | C / Na+ | Q, A, N, C, H, S | brain, retina, heart, placenta, adrenal gland |
SLC38A2 | SNAT2 | ATA2, SAT2 | C / Na+ | A, N, C, Q, G, H, M, P, S | ubiquitous |
SLC38A3 | SNAT3 | SN1 | C / Na+, E / H+ | Q, H, A, N | liver, skeletal muscle, kidney, pancreas |
SLC38A4 | SNAT4 | ATA3, NAT3, PAAT | C / Na+ | A, N, C, G, S, T | brain, retina, liver, kidney, adipose tissue |
SLC38A5 | SNAT5 | SN2 | C / Na+, E / H+ | Q, N, H, S | stomach, brain, liver, lung, small intestine, spleen, colon, kidney |
SLC38A6 | SNAT6 | brain, eye, heart, liver, kidney | |||
SLC38A7 | SNAT7 | ? / Na+ | Q, H, S ,A, N | brain, liver, skeletal muscle, uterus, pituitary | |
SLC38A8 | SNAT8 | ? / Na+ | Q, H, A, N [PMID: 25451601] | brain, pituitary, thymus, stomach, adrenal gland | |
SLC38A9 | N/A | R, Q, H, P, K, E, L | ubiquitous | ||
SLC38A10 | N/A | brain, pituitary, lung, kidney, liver | |||
SLC38A11 | N/A | testes, stomach, skeletal muscle, pituitary, adrenal gland |
[+] SLC39 Metal ion transporter family
References
Original version of the SLC table:
Jeong J, Eide DJ. The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr;34(2-3):612-9.
Original version of the SLC table:
Jeong J, Eide DJ. The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr;34(2-3):612-9.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC39A1 | ZIP1, ZIRTL | Zn | widespread | ||
SLC39A2 | ZIP2, Eti-1, 6A1 | Zn | widespread | ||
SLC39A3 | ZIP3 | Zn, not specific | widespread, mammary cells, testis | ||
SLC39A4 | ZIP4 | Zn | gastrointestinal tract, kidney hippocampal neurons | ||
SLC39A5 | ZIP5, LZT-Hs7 | Zn | pancreas, kidney, liver, stomach, intestine | ||
SLC39A6 | ZIP6, LIV-1 | Zn | widespread | ||
SLC39A7 | ZIP7, HKE4, RING5 | Zn, Mn | widespread | ||
SLC39A8 | ZIP8, BIGM103, LZT-Hs6 | Zn, Cd, Mn | widespread, T-cells, erythroid, testis | ||
SLC39A9 | ZIP9 | ||||
SLC39A10 | ZIP10, LZT-Hs2 | Zn | brain, liver, erythroid, kidney | ||
SLC39A11 | ZIP11 | ||||
SLC39A12 | ZIP12j, LZT-Hs8 | Zn | brain, lung, testis, retina | ||
SLC39A13 | ZIP13, LZT-Hs9 | Zn | widespread | ||
SLC39A14 | ZIP14, LZT-Hs4 | Zn, Fe, Mn, Cd | widespread, liver |
[+] SLC40 Basolateral iron transporter family
References
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC40A1 | ferroportin (FPN1) | MTP1, IREG1 | F ? | ferrous iron | duodenum, macrophages, liver Kupffer cells, placenta, kidney |
[+] SLC41 MgtE-like magnesium transporter family
References
Original version of the SLC table:
Sahni J, Scharenberg AM. The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr;34(2-3):620-8.
Original version of the SLC table:
Sahni J, Scharenberg AM. The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr;34(2-3):620-8.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC41A1 | MgtE | Ch | Mg2+ (Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, Cd2+) | kidney, heart, testis, skeletal muscle, prostate, adrenal gland, thyroid | |
SLC41A2 | SLC41A1-L1, SLC41A1-like 1 | Ch | Mg2+ (Ba2+, Ni2+, Co2+, Fe2+, Mn2+) | highest expression in cerebellum, lymph nodes, stomach, lungs, testis, skin | |
SLC41A3 | SLC41A1-L2, SLC41A1-like 2, FLJ20473 | Ch? (predicted based on homology with the other 2 members/MgtE transporter) |
[+] SLC42 Rh ammonium transporter family
References
Original version of the SLC table:
Nakhoul NL, Lee Hamm L. Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport. Mol Aspects Med. 2013 Apr;34(2-3):629-37.
Original version of the SLC table:
Nakhoul NL, Lee Hamm L. Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport. Mol Aspects Med. 2013 Apr;34(2-3):629-37.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC42A1 | RhAG | RHAG (Rh50A) | H+ | NH4+, NH3 | red blood cells |
SLC42A2 | RhBG | RHBG | electrogenic, no coupled ions | NH4+, NH3, methyl amine, methyl ammonium | kidney, liver, skin, GI tract, sweat glands, ovaries |
SLC42A3 | RhCG | RHCG (RhGK) | electroneutral, possibly H+ | NH4+, NH3 | kidney, brain, testis, placents, pancreas, prostate |
[+] SLC43 Na+-independent, system-L-like amino acid transporter family
References
Original version of the SLC table:
Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palacín M. The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med. 2013 Apr;34(2-3):638-45.
Original version of the SLC table:
Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palacín M. The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med. 2013 Apr;34(2-3):638-45.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC43A1 | LAT3 | POV1 | F | L-BCAAs, amino alcohols | liver, skeletal muscle, placenta, kidney podocytes |
SLC43A2 | LAT4 | F | L-BCAAs, amino alcohols | placenta, kidney, peripheral blood leukocytes, small intestine | |
SLC43A3 | EEG1 | FOAP-13 | O | liver, heart, lung, kidney |
[+] SLC44 Choline-like transporter family
References
Original version of the SLC table:
Traiffort E, O'Regan S, Ruat M. The choline transporter-like family SLC44: Properties and roles in human diseases. Mol Aspects Med. 2013 Apr;34(2-3):646-54.
Original version of the SLC table:
Traiffort E, O'Regan S, Ruat M. The choline transporter-like family SLC44: Properties and roles in human diseases. Mol Aspects Med. 2013 Apr;34(2-3):646-54.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC44A1 | CTL1 | CDw92, CHTL1 | E? | choline | brain and spinal cord neurons and oligodendrocytes, colon (mucosal cells), lung, numerous tumoral or non-tumoral cell lines |
SLC44A2 | CTL2 | PP1292 | O | choline | tongue, muscle, kidney, heart, lung, testis, intestine stomach, inner ear (vestibular supporting cells) |
SLC44A3 | CTL3 | MGC45474 | O | kidney, ileum, colon | |
SLC44A4 | CTL4 | NG22, FLJ14491 | O | intestine, stomach, kidney | |
SLC44A5 | CTL5 | MGC34032 | O | brain, spinal cord |
[+] SLC45 H+/sugar cotransporter family
References
Original version of the SLC table:
Vitavska O, Wieczorek H. The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr;34(2-3):655-60.
Original version of the SLC table:
Vitavska O, Wieczorek H. The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr;34(2-3):655-60.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC45A1 | SLC45A1 | Past-A, DNB5 | C / H+ | glucose, galactose, sucrose | brain, fetal kidney |
SLC45A2 | SLC45A2 | MATP, AIM1, underwhite | C / H+ [PMID: 25164149] | sucrose, glucose, fructose [PMID: 25164149] | skin, eye, melanocyte |
SLC45A3 | SLC45A3 | Prostein | C / H+ [PMID: 25164149] | sucrose, glucose, fructose [PMID: 25164149] | prostate, kidney [PMID: 27228996], liver, uterus, brain |
SLC45A4 | SLC45A4 | KIAA1126 | C / H+ [PMID: 25164149] | sucrose, glucose, fructose [PMID: 25164149] | ubiquitous, with maxima in brain, spinal marrow and testis |
[+] SLC46 Folate transporter family
References
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC46A1 | PCFT | HCP1 | C / proton-symporter | Reduced folates, folic acid, antifolates | small intestine, choroid plexus, kidney (proximal tubule), liver (sinusoidal), placenta |
SLC46A2 | TSCOT | Ly110 | unknown | Thymus, epididymis | |
SLC46A3 | Uncertain; lysosomal export of maytansine conjugates | Ubiquitous |
[+] SLC47 Multidrug and Toxin Extrusion (MATE) family
References
Original version of the SLC table:
Motohashi H, Inui K. Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med. 2013 Apr;34(2-3):661-8.
Original version of the SLC table:
Motohashi H, Inui K. Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med. 2013 Apr;34(2-3):661-8.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC47A1 | MATE1 | tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, metformin, guanidine, procainamide, cephalexin, cephradine | liver, kidney, muscle | ||
SLC47A2 | MATE2-K (MATE2, MATE2-B) | TEA, MPP, cimetidine, metformin, guanidine, procainamide | kidney (MATE2-K) |
[+] SLC48 Heme transporter family
References
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC48A1 | HRG-1 | C / H+ ? | heme | liver, heart, CNS, kidney, skeletal muscle, small intestine |
[+] SLC49 FLVCR-related transporter family
References
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC49A1 | FLVCR1 | FLVCR, MFSD7B, AXPC1, PCARP | unknown | heme | ubiquitous, high expression in intestine, liver, kidney, brain, bone marrow |
SLC49A2 | FLVCR2 | MFSD7C, CCT, EPV, PVHH, FLVCRL14q | unknown | heme | liver, kidney, brain, lung, placenta, fetal liver, bone marrow |
SLC49A3 | MFSD7 | LP2561, FLJ22269 | unknown | unknown | pancreas, spleen, brain, lung, ovary, breast |
SLC49A4 | DIRC2 | RCC4, FLJ14784 | unknown | unknown | pancreas, kidney, liver, placenta, heart |
[+] SLC50 Sugar efflux transporters
References
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC50A1 | RAG1AP | HsSWEET1 | F | glucose | ubiquitous expression, with highest expression in oviduct, epididymis, intestine |
[+] SLC51 Transporters of steroid-derived molecules
References
Original version of the SLC table:
Ballatori N, Christian WV, Wheeler SG, Hammond CL. The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: A transporter for steroid-derived molecules. Mol Aspects Med. 2013 Apr;34(2-3):683-92.
Original version of the SLC table:
Ballatori N, Christian WV, Wheeler SG, Hammond CL. The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: A transporter for steroid-derived molecules. Mol Aspects Med. 2013 Apr;34(2-3):683-92.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC51A | OST alpha | OST alpha-OST beta | F | bile acids | intestine |
SLC51B | OST beta | steroids | liver, kidney, testes, ovary, adrenal gland |
[+] SLC52 Riboflavin transporter family
References
Original version of the SLC table:
Yonezawa A, Inui K. Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol Aspects Med. 2013 Apr;34(2-3):693-701.
Original version of the SLC table:
Yonezawa A, Inui K. Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol Aspects Med. 2013 Apr;34(2-3):693-701.
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC52A1 | RFVT1, RFT1, GPR172B, PERV-A receptor 2, GPCR42, PAR2, FLJ10060 | Na+, Cl-, pH-independent | placenta > small intestine, etc | ||
SLC52A2 | RFVT2, RFT3, GPR172A, PERV-A receptor 1, GPCR41, PAR1, D15Ertd747e, FLJ11856 | Na+, Cl-, pH-independent | brain > salivary gland > several tissues | ||
SLC52A3 | RFVT3, RFT2, C20orf54, RIKEN cDNA 2310046K01, hypothetical protein LOC113278, bA371L19.1 | C / Na+, Cl-indep., pH sensitive | testis > small intestine > prostate, etc |
[+] SLC53 Phosphate carriers
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC53A1 | XPR1 | SYG1, XR | Phosphate [PMID: 23791524] | Ubiquitous [PMID: 9990033, 9927670], brain [PMID: 25938945], kidney [PMID: 27799484] |
[+] SLC54 Mitochondrial pyruvate carriers
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC54A1 | MPC1 | BRP44L | Pyruvate [PMID: 22628554] [PMID: 22628558] | Ubiquitous [PMID: 27317664] | |
SLC54A2 | MPC2 | BRP44 | Pyruvate [PMID: 22628558] | Ubiquitous [PMID: 27317664] | |
SLC54A3 | MPC1L | Pyruvate [PMID: 27317664] | Testis, postmeiotic spermatids and sperm cells [PMID: 27317664] |
[+] SLC55 Mitochondrial cation/proton exchangers
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC55A1 | LETM1 | Mdm38 homolog (yeast) | E / Ca2+:H+ [PMID: 19797662] [PMID: 27669901], E / K+:H+ [PMID: 15138253] [PMID: 17925330] | Ca2+, K+, H+ (K+: [PMID: 20197279] [PMID: 15138253], [PMID: 17925330], yeast protein: [PMID: 17541427]), arguments against Ca2+ transport [PMID: 20197279]. | Ubiquitous [PMID: 10486213] |
SLC55A2 | LETM2 | FLJ25409 | |||
SLC55A3 | LETMD1 | HCCR, HCCR-1, HCCR-2 |
[+] SLC56 Sideroflexins
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC56A1 | SFXN1 | FLJ12876 | Probably falsely identified as a tricarboxylate carrier in [PMID: 8132491] as discussed in [PMID: 11274051]. Likely transports pyridoxin or another heme precursor or ALAS2 cofactor [PMID: 11274051] [PMID: 12670026]. | Mostly adult kidney and liver (mouse) [PMID: 11274051] | |
SLC56A2 | SFXN2 | Mostly adult kidney and liver (mouse) [PMID: 11274051], widely expressed, highest levels in kidney, liver, pancreas (human) [PMID: 12670026] | |||
SLC56A3 | SFXN3 | Ubiquitous (mouse) [PMID: 11274051] | |||
SLC56A4 | SFXN4 | Kidney, brain, heart (mouse) [PMID: 11274051], widely expressed, SFXN4a highest in kidney and pancreas, SFXN4b barely detectable in brain (human) [PMID: 14756423] | |||
SLC56A5 | SFXN5 | Liver, brain (mouse) [PMID: 11274051] |
[+] SLC57 NiPA-like magnesium transporter family
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC57A1 | NIPA1 | Mg2+ [PMID: 17166836], also Sr2+, Fe2+ and Co2+ to a lesser extent [PMID: 18667602] | Constitutively express at low levels, significant enrichment in the brain (human) [PMID: 14508710]; widely expressed, including heart, kidney, liver, colon, less in the brain, not in the small intestine (mouse) [PMID: 17166836] | ||
SLC57A2 | NIPA2 | Mg2+ [PMID: 18667602] | |||
SLC57A3 | NIPAL1 | NIPA3 [PMID: 18667602] | Mg2+, Sr2+, Ba2+, Fe2+, Cu2+ [PMID: 18667602] | ||
SLC57A4 | NIPAL2 | NIPA4 [PMID: 18667602] | Mg2+, Sr2+, Ba2+ [PMID: 18667602] | ||
SLC57A5 | NIPAL3 | NPAL3 | |||
SLC57A6 | NIPAL4 | ichthyin, NIPA4 |
[+] SLC58 MagT-like magnesium transporter family
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC58A1 | MAGT1 | Channel-like [PMID: 19940067] | Mg2+ [PMID: 15804357] | Kidney, colon, heart, liver (latter only at the mRNA level) [PMID: 15804357], univerally expressed [PMID: 19717468] | |
SLC58A2 | TUSC3 | N33 | Mg2+, Fe2+, Cu2+, Mn2+ [PMID: 18667602] [PMID: 19940067] | Placenta, pancreas, testis, ovary, heart, prostate [PMID: 8661104] |
[+] SLC59 Sodium-dependent lysophosphatidylcholine symporter family
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC59A1 | MFSD2A | MFSD2 | C / LPC:Na+, uptake [PMID: 24828044] | LPC (lysophosphatidylcholine) form of DHA (docosahexaenoic acid) [PMID: 24828044] | Brain, intestine, kidney, liver, lung, mammary gland, prostate [PMID: 18694395]. Relative low expression in BAT (brown adipose tissue), but upregulated during cold-induced thermogenesis [PMID: 18694395]. |
SLC59A2 | MFSD2B | Spleen, lung, testis [PMID: 18694395] |
[+] SLC60 Glucose transporters
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC60A1 | MFSD4A | ||||
SLC60A2 | MFSD4B | C / Na+ (1:1) uptake [PMID: 12590146] | α-Me-glucose, D-glucose [PMID: 12590146], inhibited by phlorizin [PMID: 12590146], also inhibited by 2-DG, slightly by fructose and phloretin [PMID: 12590146]; urea [PMID: 26423860] | Kidney cortex and medulla, brain, liver, lung (rat) [PMID: 12590146] |
[+] SLC61 Molybdate transporter family
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC61A1 | MFSD5 | Molybdate [PMID: 21464289] | Cervix, stomach, nerve and skin [PMID: 21464289]; ubiquitous but higher in skeletal muscle, olfactory bulb [PMID: 18948099]; blood, cortex, hypothalamus, cerebellum, spinal cord (mouse) [PMID: 27272503]. |
[+] SLC62 Pyrophosphate transporters
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC62A1 | ANKH | Pyrophosphate [PMID: 10894769] | Kidney, bone [PMID: 19910700] |
[+] SLC63 Sphingosine-phosphate transporters
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC63A1 | SPNS1 | ||||
SLC63A2 | SPNS2 | Phosphorylated sphingolipids [PMID: 19074308]; phosphorylated Fingolimod (FTY720-P) [PMID: 21084291]; sphingosine-1-phosphate (S1P), dihydrosphingosine-1-phosphate (DH-S1P), phyto-S1P, C17-S1P [PMID: 21084291] | Lung, placenta, abundant in many other tissues [PMID: 21084291] | ||
SLC63A3 | SPNS3 |
[+] SLC64 Golgi Ca2+/H+ exchangers
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC64A1 | TMEM165 | E / Ca2+:H+ | Ca2+, H+ [PMID: 23569283]; or Mn2+ [PMID: 27008884] [PMID: 28270545] |
[+] SLC65 NPC-type cholesterol transporters
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC65A1 | NPC1 | Cholesterol [PMID: 17989073] [PMID: 17989072] [PMID: 27410046] | Ubiquitous, highest in liver, lung, pancreas [PMID: 10783261]; ubiquitous [PMID: 14976318] | ||
SLC65A2 | NPC1L1 | Cholesterol [PMID: 14976318] | Small intestine, gallbladder, liver, testis, stomach [PMID: 14976318] |
[+] SLC66 PQ-loop amino acid transporters
References
Original version of the SLC table:
Original version of the SLC table:
SLC name | Protein name | Aliases | Transport type* | Substrates | Tissue and cellular expression |
SLC66A1 | PQLC2 | L-Arg, L-Lys, L-His, L-canavenine, L-ornithine, MxD (cysteamine and cysteine mixed disulfide) [PMID: 22822152] [PMID: 23169667] | N/D | ||
SLC66A2 | PQLC1 | N/D | N/D | ||
SLC66A3 | PQLC3 | N/D | N/D | ||
SLC66A4 | CTNS | E / H+ [PMID: 11689434] [PMID: 22232659] | L-cystine [PMID: 11689434], L-selenocystine, L-cystathionine [PMID: 22232659] | Tubular epithelial cells of the kidney (mostly proximal tubules) [12138135, 18337546, 22544350], testis (particularly Leydig cells and germinal cells), pancreas (particularly islets of Langerhans), liver, placenta, skin (particularly pilosebacious units, keratinocytes, melanocytes, capillaries and venules), lungs (bronchial muco-serous glandular cells) [22544350] | |
SLC66A5 | MPDU1 | N/D | N/D | N/D |
* Abbreviations for transport type: C: Cotransporter; E: Exchanger; F: Facilitated transporter; O: Orphan transporter.