SLCtables

References
Original version of the SLC table:
Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr;34(2-3):108-20.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC1A1	EAAC1, EAAT3	System X-AG	C / Na+, H+, K+	L-Glu, D/L-Asp	brain (neurons), intestine, kidney, liver, heart, placenta
SLC1A2	GLT-1, EAAT2	System X-AG	C / Na+, H+, K+	L-Glu, D/L-Asp	brain (astrocytes, Bergmann glia, neurons), liver, pancreas
SLC1A3	GLAST, EAAT1	System X-AG	C / Na+, H+, K+	L-Glu, D/L-Asp	brain (astrocytes, Bergmann glia), heart, skeletal muscle, placenta
SLC1A4	ASCT1, SATT	System ASC	C / Na+, E / amino acids	L-Ala, L-Ser, L-Cys, L-Thr	widespread
SLC1A5	ASCT2, AAAT	System ASC	C / Na+, E / amino acids	L-Ala, L-Ser, L-Cys, L-Thr, L-Gln, L-Asn	lung, skeletal muscle, large intestine, kidney, testis, adipose tissue
SLC1A6	EAAT4	System X-AG	C / Na+, H+, K+	L-Glu, D/L-Asp	cerebellum (Purkinje cells)
SLC1A7	EAAT5	System X-AG	C / Na+, H+, K+	L-Glu, D/L-Asp	retina (rod photoreceptors, bipolar cells)

References
Original version of the SLC table:
Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr;34(2-3):121-38.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC2A1	GLUT1		F	glucose, galactose, mannose, glucosamine	erythrocytes, brain, blood-brain barrier, blood-tissue barrier, many fetal tissues
SLC2A2	GLUT2		F	glucose, galactose, fructose, mannose, glucosamine	liver, islet of Langerhans, intestine, kidney, brain
SLC2A3	GLUT3		F	glucose, galactose, mannose, xylose	brain (neurons), testis
SLC2A3P1	pseudogene	GLUT3 pseudogene 1
SLC2A3P2	pseudogene	GLUT3 pseudogene 2
SLC2A3P4	pseudogene	GLUT3 pseudogene 4
SLC2A4	GLUT4		F	glucose, glucosamine	adipose tissue (white, brown), skeletal, cardiac muscle
SLC2A5	GLUT5		F	fructose	small intestine, kidney
SLC2A6	GLUT6	GLUT9	F	glucose	brain, spleen, leucocytes
SLC2A7	GLUT7		F	glucose, fructose	small intestine, colon, testis, prostate
SLC2A8	GLUT8	GLUTX1	F	glucose, fructose, galactose	testis, brain, adrenal gland, liver, spleen, brown adipose tissue, lung
SLC2A9	GLUT9	GLUTX, URATv1		urate (glucose, fructose)	kidney, liver, small intestine, placenta, lung, leucocytes
SLC2A10	GLUT10		F	glucose, galactose	heart, lung, brain, liver, skeletal muscle, pancreas, placenta, kidney
SLC2A11	GLUT11	GLUT10	F	glucose, fructose	heart, muscle
SLC2A12	GLUT12	GLUT8	F	glucose	heart, prostate, skeletal muscle, placenta
SLC2A13	HMIT	GLUT13	C / H+	myo-inositol	brain, adipose tissue
SLC2A14	GLUT14	SLC2A3P3	O		testis
SLC2AXP1	pseudogene

References
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC3A1	rBAT	NBAT, D2H	E (see details in SLC7 table)	system b0,+, heterodimerizes with light subunit SLC7A9	kidney, small intestine, liver, pancreas
SLC3A2	4F2hc	CD98hc, FRP	E (see details in SLC7 table)	systems L, y+L, xc- and asc with light subunits SLC7A5-8 and SLC7A10-11	ubiquitous

References
Original version of the SLC table:
Romero MF, Chen AP, Parker MD, Boron WF. The SLC4 family of bicarbonate (HCO3(-)) transporters. Mol Aspects Med. 2013 Apr;34(2-3):159-82.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC4A1	AE1	Band 3	E	chloride cicarbonate	erythrocytes, intercalated cells of renal collecting duct, heart, colon
SLC4A2	AE2		E	chloride bicarbonate	widely distributed
SLC4A3	AE3		E	chloride bicarbonate	brain, retina, heart, smooth muscle, also epithelial cells of kidney, GI tract
SLC4A4	NBCe1	NBC, NBC1	C	sodium bicarbonate (and/or carbonate)	NBCe1-A: renal proximal tubule, eye, NBCe1-B: widely distributed, pancreas, heart, eye, NBCe1-C: brain
SLC4A5	NBCe2	NBC4	C	sodium bicarbonate (and/or carbonate)	liver, testes, spleen
SLC4A7	NBCn1	NBC2, NBC3, SLC4A6	C	chloride bicarbonate	widely distributed, spleen, testes, brain, heart, lung, liver, kidney; not skeletal muscle
SLC4A8	NDCBE	kNBC3	C, E	sodium bicarbonate chloride	brain, testes, kidney, ovary
SLC4A9		AE4		inconclusive	at least kidney
SLC4A10	NBCn2	NCBE	C, E	sodium bicarbonate chloride	brain
SLC4A11	BTR1	NaBC1	C	sodium, borate	kidney, salivary gland testis, thyroid, trachea

References
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC5A1	SGLT1	None	C / Na+, (H+), F / Na+, (H+), Ch / urea, water	glucose and galactose (urea and water)	small intestine, trachea, kidney, heart, brain, testes, prostrate
SLC5A2	SGLT2	None	C / Na+	glucose	kidney, brain, liver, heart muscle, thyroid, salivary glands
SLC5A3	SMIT1	None	C / Na+	myoinositol (glucose)	brain, heart, kidney, lung
SLC5A4	SGLT3	SAAT1	glucose activated Na+, (H+) channel	Na+ (H+)	small intestine (cholinergic neurons), skeletal muscle, kidney, uterus, testis
SLC5A5	NIS		C / Na+, F / Na+, Ch / urea, water	I- (ClO4-, SCN-, NO3-, Br-)	thyroid, lactating breast, colon, stomach, ovary
SLC5A6	SMVT		C / Na+	biotin, lipoate panthothenate, I-	brain, heart, kidney, lung, placenta
SLC5A7	CHT	CHT1		choline	spinal cord, medulla
SLC5A8	SMCT1	AIT	C / Na+	short chain fatty acids	small intestine, kidney, brain, retina, muscle
SLC5A9	SGLT4		C / Na+	mannose, fructose, glucose	kidney, small Intestine, brain, kidney, liver, heart, uterus, lung
SLC5A10	SGLT5	RK-D	C / Na+	mannose, fructose, glucose	kidney cortex
SLC5A11	SMIT2	SGLT6, KST1	C / Na+	myoinositol, chiro-inositol	thyroid, brain, heart, muscle, spleen, liver, lung
SLC5A12	SMCT2		C / Na+	short chain fatty acids	intestine, brain, retina, muscle

References
Original version of the SLC table:
Pramod AB, Foster J, Carvelli L, Henry LK. SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr;34(2-3):197-219.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC6A1		GAT1		GABA	GABAergic neurons in brain (neocortex, hippocampus, cerebellum, basal ganglia, brain stem, olfactory bulb, glia), peripheral nervous system, retina
SLC6A2		NAT1, NET1, NET		norepinephrine	brain (non adrenergic neuronal somata, axons, dendrites), peripheral nervous system, adrenal gland (chromaffin cells), placenta
SLC6A3		DAT, DAT1		dopamine	brain (dopaminergic neurons), gut
SLC6A4		5-HTT, SERT		serotonin	brain, peripheral nervous system, placenta, epithelium cells, platelets
SLC6A5		GlyT2		glycine	brain (glycinergic neurons, Golgi cells, brain stem, cerebellum), spinal cord
SLC6A6		TauT		taurine	brain, retina, liver, kidney, heart, spleen, pancreas, placenta, skeletal muscle, lung
SLC6A7		PROT		proline	brain (glutamatergic neurons, hippocampus)
SLC6A8		CRTR, CT1		creatine	ubiquitous
SLC6A9		GlyT1		glycine	brain, retina, liver, spleen, kidney, pancreas, uterus, stomach, lung, placenta, intestine
SLC6A10		CT2			testis
SLC6A10P	pseudogene	CT2
SLC6A11		GAT-B, GAT-3		GABA	brain (GABAergic neurons, glia)
SLC6A12		BGT1		betaine, GABA	brain, kidney, liver, heart, skeletal muscle, placenta
SLC6A13		GAT2		GABA	brain (meninges, ependyma, choroid plexus), retina, liver, kidney, lung
SLC6A14		ATB0+, beta-alanine carrier system		neutral, cationic amino acids	lung, trachea, salivary gland, mammary gland, stomach, pituitary gland, intestine, uterus, prostate, testis
SLC6A15		B0AT2, v7-3, NTT7-3		large, neutral amino acids	brain (amygdala, putamen, corpus callosum), kidney
SLC6A16		NTT5		unknown	testis, pancreas, prostate
SLC6A17		NTT4, XT1		neutral amino acids	brain, heart, skeletal muscle
SLC6A18		B0AT3, XT2		neutral amino acids	kidney (proximal tubule)
SLC6A19		B0AT1, HND		neutral amino acids	intestine (duodenum, jejunum, ileum), stomach, kidney, liver, prostate
SLC6A20		system IMINO, XT3, Xtrp3		proline, pipecolate, sarcosine	brain, kidney, small intestine, thymus, spleen, ovary, lung
SLC6A21	pseudogene	SLC6A21

References
Original version of the SLC table:
Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr;34(2-3):139-58.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC7A1	CAT-1	ATRC1, system y+	F (non-obligatory E)	cationic L-amino acids	ubiquitous except for liver, lacrimal gland
SLC7A2	CAT-2 (A or B)	ATRC2, system y+	F	cationic L-amino acids	CAT-2A: liver, skeletal muscle, pancreas, CAT-2B: inducible in many cell types
SLC7A3	CAT-3	ATRC3, system y+	F	cationic L-amino acids	thymus, ovary, testis, brain (neurons)
SLC7A4	CAT-4		O		brain, testis, placenta
SLC7A5	LAT1	[4F2hc], 4F2lc, system L	E (similar intra- and extracellular selectivities, lower intracellular apparent affinity)	large neutral L-amino acids, T3, T4, L-DOPA, BCH	brain, ovary, testis, placenta, spleen, colon, blood-brain barrier, fetal liver, activated lymphocytes, tumor cells
SLC7A5P1	pseudogene	LAT1-3TM, MLAS
SLC7A6	y+LAT2	[4F2hc], system y+L	E (preferentially intracellular cationic amino acid against extracellular neutral amino acid / Na+)	cationic amino acids (Na+ indep.), large neutral L-amino acids (Na+ dep.)	brain, small intestine, testis, parotids, heart, kidney, lung, thymus
SLC7A7	y+LAT1	[4F2hc], system y+L	E (preferentially intracellular cationic amino acid against extracellular neutral amino acid / Na+)	cationic amino acids (Na+ indep.), large neutral L-amino acids (Na+ dep.)	small intestine, kidney, spleen, leucocytes, placenta, lung/ basolateral in epithelial cells
SLC7A8	LAT2	[4F2hc], system L	E (similar intra- and extracellular selectivities, lower intracellular apparent affinity)	neutral L-amino acids, T3, T4, BCH	small intestine, kidney, lung, heart, spleen, liver, brain, placenta, prostate, ovary, fetal liver, testis, skeletal muscle
SLC7A9	b0,+AT	[rBAT], system b0,+	E (preferentially extracellular cationic amino acid and cystine against intracellular neutral amino acid)	cationic amino acids, large neutral amino acids	kidney, small intestine, liver, placenta
SLC7A10	Asc-1	[4F2hc], system asc	preferentially E	small neutral amino acids	brain, CNS, lung, small intestine, heart, placenta, skeletal muscle, kidney
SLC7A11	xCT	[4F2hc], system xc-	E (preferentially extracellular cystine against intracellular glutamate)	cystine (anionic form), L-glutamate	macrophages, brain, retinal pigment cells, liver, kidney
SLC7A13	AGT-1	XAT2	E	L-aspartate, L-glutamate	proximal straight tubules, distal convoluted tubules
SLC7A14			O		highly expressed in CNS
SLC7A15P	pseudogene

References
Original version of the SLC table:
Khananshvili D. The SLC8 gene family of sodium-calcium exchangers (NCX) - Structure, function, and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):220-35.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC8A1	NCX1	NACA, NCE	E / Na+, Ca2+	Na+, Ca2+	ubiquitous tissue distribution; specific splice variants found in brain, heart, kidney, pancreas
SLC8A2	NCX2		E / Na+, Ca2+	Na+, Ca2+	abundant in neurons in all parts of the brain, but not present at significant levels elsewhere
SLC8A3	NCX3		E / Na+, Ca2+	Na+, Ca2+	expressed selectively in skeletal muscle, at lower levels in some brain regions
SLC8B1	NCLX	mNCX	E / Na+, Li+, Ca2+	Na+, Li+, Ca2+	found in mitochondria of mammalian skeletal and heart muscle, neurons, β-cells and B-cells, liver contains relatively small amounts

References
Original version of the SLC table:
Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med. 2013 Apr;34(2-3):236-51.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC9A1	NHE1	APNH?	E / Na+, H+	Na+, Li+, H+, NH4+	Most mammalian cells, except macula densa and α- and β-intercalated cells of the kidney
SLC9A2	NHE2		E / Na+, H+	Na+, Li+, H+, NH4+	Brush border of small intestine, colon, gallbladder, stomach, endothelial cells, kidney
SLC9A3	NHE3		E / Na+, H+	Na+, Li+, H+, NH4+	Small intestine, colon, gallbladder, renal proximal tubule, thick and thin limbs of the loop of Henle, gastric parietal cells, epididymis, ovary, thymus, prostate, medulla oblongata, pons
SLC9A3P1	pseudogene
SLC9A3P2	pseudogene
SLC9A3P3	pseudogene
SLC9A3P4	pseudogene
SLC9A4	NHE4		E / Na+, H+	Na+, Li+ (?), H+, NH4+	Stomach, kidney medulla, hippocampus, zymogen granule of pancreas, salivary gland
SLC9A5	NHE5		E / Na+, H+	Na+, Li+, H+, NH4+ (?)	Brain
SLC9A6	NHE6		E / Na+ (K+), H+	Na+, K+, H+	Brain
SLC9A7	NHE7		E / Na+ (K+), H+	Na+, K+, Li+, H+, NH4+ (?)	Most mammalian cells
SLC9A7P1	pseudogene, partially processed
SLC9A8	NHE8		E / Na+ (K+), H+	Na+, K+, H+	Kidney, intestine
SLC9A9	NHE9		E / Na+ (K+), H+	Na+, K+, H+	Brain
SLC9B1	NHA1	NHEDC1			Testis
SLC9B2	NHA2	NHEDC2		Na+, Li+	Distal convoluted tubules of kidney, osteoclasts, β-cells of endocrine pancreas
SLC9C1	Sperm-NHE			Na+, H+	Spermatozoa
SLC9C2

References
Original version of the SLC table:
Claro da Silva T, Polli JE, Swaan PW. The solute carrier family 10 (SLC10): Beyond bile acid transport. Mol Aspects Med. 2013 Apr;34(2-3):252-69.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC10A1	NTCP	LBAT	C / Na+	bile acids	liver, pancreas
SLC10A2	ASBT	IBAT, ISBT, NTCP2	C / Na+	bile acids	ileum, kidney, biliary tract
SLC10A3	P3		O		ubiquitous
SLC10A4	P4		O		brain (cholinergic neurons), placenta, liver
SLC10A5	P5		O		liver, kidney
SLC10A6	SOAT	P6	C / Na+	estrone-3-sulfate, dehydroepiandrosterone sulfate, pregnenolone sulfate	testis, placenta, pancreas
SLC10A7	P7	C4orf13	O		liver, testis

References
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC11A1	NRAMP1	NRAMP, LSH	E or C ? / H+	Mn2+, Fe2+, other divalent metal ions	phagolysosomes of phagocytes (macrophages, neutrophils)
SLC11A2	DMT1	NRAMP2, DCT1	C / H+	Fe2+, Cd2+, Co2+, Cu1+, Mn2+, Ni2+, Pb2+, Zn2+	widespread, including intestine (duodenum), erythroid cells, kidney, lung, brain, testis (Sertoli cells), thymus

References
Original version of the SLC table:
Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Mol Aspects Med. 2013 Apr;34(2-3):288-98.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC12A1	NKCC2			Na+, K+, Cl-	kidney specific
SLC12A2	NKCC1			Na+, K+, Cl-	ubiquitous
SLC12A3	NCC			Na+, Cl-	kidney, bone
SLC12A4	KCC1			K+, Cl-	ubiquitous
SLC12A5	KCC2			K+, Cl-	neurons
SLC12A6	KCC3			K+, Cl-	extensive
SLC12A7	KCC4			K+, Cl-	extensive, limited in brain
SLC12A8	CCC9			unknown	extensive
SLC12A9	CIP			polyamines?	extensive

References
Original version of the SLC table:
Bergeron MJ, Clémençon B, Hediger MA, Markovich D. SLC13 family of Na(+)-coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr;34(2-3):299-312.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC13A1	NaS1	Na-sulfate, NaSi-1	C / Na+	sulfate, selenate, thiosulfate	kidney, proximal tubular cells
SLC13A2	NaC1	SDCT1, NaDC-2, NaDC1	C / Na+	succinate, citrate, ?-ketoglutarate	kidney, intestine
SLC13A3	NaC3	NaDC3, NaC3, SDCT2	C / Na+	succinate, citrate, ?-ketoglutarate, NALA, glutarate and its derivatives	kidney, proximal tubule, liver, pancreas, brain, placenta
SLC13A4	NaS2	SUT1	C / Na+	sulfate, oxyanions selenium and chromium	placenta, tonsillar high endothelial venules, testis, heart
SLC13A5	NaC2	NaCT	C / Na+	citrate, succinate, pyruvate	liver, brain, testis

References
Original version of the SLC table:
Shayakul C, Clémençon B, Hediger MA. The urea transporter family (SLC14): Physiological, pathological and structural aspects. Mol Aspects Med. 2013 Apr;34(2-3):313-22.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC14A1_UT-B1		UT3, UT11, JK, Kidd antigen			descending vasa recta, papillary epithelia, erythrocyte, bone marrow, urinary tract, bladder, small intestine, colon, brain, thymus, heart, lung, liver, spleen, pancreas, skeletal muscle, ear, prostate, testis (Sertoli cells)
SLC14A1_UT-B2					caudate nucleus (human), rumen (bovine), thymus (mouse)
SLC14A2_UT-A1		UT1			inner medullary collecting duct, cochlea
SLC14A2_UT-A2		UT2			descending thin limb of Henle's loop, liver, heart
SLC14A2_UT-A3		UT4			inner medullary collecting duct, cochlea
SLC14A2_UT-A4					renal medullab (rat)
SLC14A2_UT-A5					testis (mouse)
SLC14A2_UT-A6					colon (human)

References
Original version of the SLC table:
Smith DE, Clémençon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med. 2013 Apr;34(2-3):323-36.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC15A1	PEPT1	oligopeptide transporter 1, H+-peptide transporter 1	C / H+	di- and tri-peptides, protons, beta-lactam antibiotics	small intestine, kidney, pancreas, bile duct, liver
SLC15A2	PEPT2	oligopeptide transporter 2, H+-peptide transporter 2	C / H+	di- and tri-peptides, protons, beta-lactam antibiotics	apical surface of epithelial cells from kidney and choroid plexus; neurons, astrocytes (neonates), lung, mammary gland, spleen, enteric nervous system
SLC15A3	PHT2	peptide/histidine transporter 2, PTR3	C / H+	di- and tri-peptides, protons, histidine	lung, spleen, thymus, intestine (faintly in brain, liver, adrenal gland, heart)
SLC15A4	PHT1	peptide/histidine transporter 1, PTR4	C / H+	di- and tri-peptides, protons, histidine	brain, eye, intestine (faintly in lung and spleen)

References
Original version of the SLC table:
Halestrap AP. The SLC16 gene family - Structure, role and regulation in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):337-49.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC16A1	MCT1,	MOT1	C / H+ or E / monocarboxylate	lactate, pyruvate, ketone bodies	ubiquitous except beta cells of endocrine pancreas
SLC16A2	MCT8	MOT8, XPCT, MCT7	F	T2, rT3, T3, T4	most tissues including liver, heart, brain, thymus, intestine, ovary, prostate, pancreas, placenta, lung kidney, skeletal muscle
SLC16A3	MCT4	MOT4, MCT3	C / H+	lactate, ketone bodies	skeletal muscle, chondrocytes, leukocytes, testis, lung, ovary, placenta, heart
SLC16A4	MCT5	MOT5, MCT4	O		brain, muscle, liver, kidney, lung, ovary, placenta, heart
SLC16A5	MCT6	MOT6, MCT5		bumetanide, probenecid, nateglinide ?	kidney, muscle, brain, heart, pancreas, prostate, lung, placenta
SLC16A6	MCT7	MOT7, MCT6	O		brain, pancreas, muscle, prostate
SLC16A7	MCT2	MOT2	C / H+	pyruvate, lactate, ketone bodies	high expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain, leukocyte
SLC16A8	MCT3	MOT3, REMP	C / H+ (pH dependent but cotransport not confirmed experimentally)	lactate	retinal pigment epithelium, choroid plexus
SLC16A9	MCT9	MOT9	O		endometrium, testis, ovary, breast, brain, kidney, spleen adrenal, retina
SLC16A10	TAT1, MCT10	MOT10	F	aromatic amino acids, T3, T4	kidney, intestine, muscle, placenta, heart
SLC16A11	MCT11	MOT11	O		skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, choroid plexus
SLC16A12	MCT12	MOT12	O		kidney, retina, lung testis
SLC16A13	MCT13	MOT13	O		breast, bone marrow stem cells
SLC16A14	MCT14	MOT14	O		brain, heart, muscle, ovary, prostate, breast, lung, pancreas liver, spleen, thymus

References
Original version of the SLC table:
Reimer RJ. SLC17: A functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr;34(2-3):350-9.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC17A1	NPT1	NaPi1	electrogenic, Cl- dependent; C/Na+; channel	organic anions, phosphate, chloride	kidney, liver
SLC17A2	NPT3		unknown	unknown	heart, muscle, brain, placenta, lung, liver kidney, pancreas
SLC17A3	NPT4		electrogenic	organic anions	liver, kidney, small intestine, testis
SLC17A4	Na+/PO4-cotransporter homologue		unknown	unknown	small intestine, colon, liver, pancreas
SLC17A5	sialin	AST, VEAT	C / H+	sialic acid, other acidic sugars	ubiquitous
SLC17A6	VGLUT2	DNPI	electrogenic, Cl- dependent	glutamate	brain (neurons only), endocrine
SLC17A7	VGLUT1	BNPI	electrogenic, Cl- dependent	glutamate	brain (neurons only), endocrine
SLC17A8	VGLUT3		electrogenic, Cl- dependent	glutamate	brain (neurons, glia), liver, kidney
SLC17A9	VNUT		electrogenic, Cl- dependent	purine nucleotides	brain (neurons), adrenal, thyroid

References
Original version of the SLC table:
Lawal HO, Krantz DE. SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr;34(2-3):360-72.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC18A1	VMAT1	CGAT, VAT	E / H+	5-HT, DA, NE, epinephrine	sympathetic ganglia, some GI neurons, adrenal medulla
SLC18A2	VMAT2	SVAT, SVMT, VAT2, MAT	E / H+	5-HT, DA, NE, epinephrine, histamine	all CNS aminergic neurons, mast cells, platelets, some GI neurons, adrenal medulla
SLC18A3	VAChT	Unc-17, Vesamicol binding protein	E / H+	acetylcholine	cholinergic neurons, pancreatic stellate cells, tracheal brush cells
SLC18B1	C6orf192	hypothetical human protein LOC116843, dJ55C23.6 gene product	unknown	unknown	broad, including brain, lung

References
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC19A1	RFC	RFC1, RFT	E / organic phosphates	reduced folates, antifolates	ubiquitous
SLC19A2	THTR1	ThTr1	F	thiamine	ubiquitous
SLC19A3	THTR2	ThTr2	F	thiamine	ubiquitous

References
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC20A1	PiT-1	gibbon ape leukemia virus receptor 1, GLVR1, Glvr1, FLJ41426, DKFZp686J2397	C / Na+, H2PO4-	inorganic phosphate (monovalent)	widely expressed
SLC20A2	PiT-2	amphotropic murine leukemia virus receptor 2, GLVR2, Glvr-2, MLVAR	C / Na+, H2PO4-	inorganic phosphate (monovalent)	widely expressed, kidney (proximal tubule)

References
Original version of the SLC table:
Hagenbuch B, Stieger B. The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med. 2013 Apr;34(2-3):396-412.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLCO2A1	OATP2A1			prostaglandins (C/lactate)	ubiquitous
SLCO4A1		OATP-E, OATP4A1
SLCO5A1		OATPRP4, OATP-J, OATP5A1
SLCO3A1		OATP-D, OATP3A1
SLCO6A1		OATP6A1, OATPY, MGC26949, CT48
SLCO1A2	OATP1A2			bile salts, organic anions and cations	brain (endothelial cells), kidney, intestine, liver (cholangiocytes), eye (ciliary body)
SLCO2B1	OATP2B1			E-3-S, DHEAS	liver (hepatocytes), placenta, intestine, eye
SLCO1B1	OATP1B1			bile salts, organic anions	liver (hepatocytes)
SLCO1B3	OATP1B3			bile salts, organic anions	liver (hepatocytes)
SLCO4C1		SLC21A20, OATP4C1, OATPX, OATP-H
SLCO1C1	OATP1C1			T4, T3, rT3	brain (blood-brain barrier), testis (Leydig cells)

References
Original version of the SLC table:
Koepsell H. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med. 2013 Apr;34(2-3):413-35.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC22A1	OCT1		F	organic cations	liver, small intestine, kidney, lung, skeletal muscle, brain (endothelial cells of blood-brain barrier), adipose tissue, immune cells
SLC22A2	OCT2		F	organic cations	kidney, small intestine, lung, placenta, thymus, brain (neurons, blood-brain barrier), inner ear
SLC22A3	OCT2	EMT (uptake-2 system)	F	organic cations	heart, skeletal muscle, brain (neurons, glial cells, plexus choroideus), small intestine, liver, lung, kidney, urinary bladder, mammary gland, skin blood vessels
SLC22A4	OCTN1	ETT	C / Na+	ergothioneine, zwitterions, organic cations	kidney, intestine, spleen, heart, skeletal muscle, brain, mammary gland, thymus, prostate, airways, testis, eye, fetal liver, sperm, immune cells
SLC22A5	OCTN2	CT1, CDSP	C / Na+, L-carnitine, F / organic cations	zwitterions (L-carnitine), organic cations	skeletal muscle, kidney, prostate, lung, pancreas, heart, small intestine, adrenal gland, thyroid gland, liver, etc.
SLC22A6	OAT1	PAHT, NKT	E / organic anions	organic anions	kidney, placenta, brain
SLC22A7	OAT2	NLT	F or E	organic anions	liver, kidney
SLC22A8	OAT3		E / dicarboxylate	organic anions	kidney, brain, skeletal muscle, developing bone
SLC22A9	OAT7	UST3, OAT4	E / short chain fatty acids	organic anions	liver
SLC22A10	OAT5		O	not determined	liver
SLC22A11	OAT4		F or E	organic anions	kidney, placenta
SLC22A12	URAT1	RST, OAT4L	E / organic anions	urate, organic anions	kidney
SLC22A13	OAT10	ORCTL3, OCTL1	E / anions	urate, organic anions	kidney, colon, small intestine, brain, heart
SLC22A14	OCTL2	ORCTL4	O	not determined	kidney, colon, small intestine
SLC22A15	FLIPT1		O	not determined	kidney, brain, liver, skeletal muscle, heart, placenta, lung, spleen
SLC22A16	39726	FLIPT2, CT2	F	L-carnitine, noncharged compounds	testis (Sertoli cells and epididymal duct cells), bone marrow, leukocytes, kidney
SLC22A17	BOIT	BOCT, NGALR	O	not determined	brain
SLC22A18		IMPT1, TSSC5, ORCTL2		probably organic anions	kidney
SLC22A20	OAT6		E / dicarboxylate	probably organic anions	olfactory mucosa
SLC22A23			O
SLC22A24			O
SLC22A25	UST6	HIMTP	O		liver
SLC22A31					larynx, prostate, pancreas, embryonic tissue
SLC22A32	MFSD10	TETRAN	C / H⁺	p-aminohippuric acid (PAH), indomethacin, diclofenac, mefenamic acid, etodolac [PMID: 18638446]	Heart, kidney (luminal membrane of proximal tubules), prostate [PMID: 18638446]
SLC22B1	SV2A			Galactose [PMID: 25326386]; also binds levetiracetam [PMID: 15210974], selectracetam [PMID: 18183537], brivaracetam [PMID: 17785672].	Brain, highest levels in subcortex (basal ganglia, thalamus) [PMID: 7681585]
SLC22B2	SV2B				Brain, highest levels in hippocampus and cortex [PMID: 7681585]
SLC22B3	SV2C				Striatum, substantia nigra, pons/medulla oblongata [PMID: 10625067]; olfactory bulb [PMID: 10625067]
SLC22B4	SVOP			Nicotinate [PMID: 21953179]; binds nucleotides in the TM region [PMID: 19390693]	Brain [PMID: 9801366]
SLC22B5	SVOPL				Brain, liver, kidney, skeletal muscle, epididymis, testis, ovary, thymus, spinal cord [PMID: 17714910]

References
Original version of the SLC table:
Bürzle M, Suzuki Y, Ackermann D, Miyazaki H, Maeda N, Clémençon B, Burrier R, Hediger MA. The sodium-dependent ascorbic acid transporter family SLC23. Mol Aspects Med. 2013 Apr;34(2-3):436-54.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC23A1	SVCT1	YSPL3, NCBT2, MGC22361	C / Na+	L-ascorbic acid	epithelial tissues including kidney, intestines, liver, lung, skin
SLC23A2	SVCT2	YSPL2, KIAA0238, NBTL1, NCBT1	C / Na+	L-ascorbic acid	widespread including brain (neurons), retina, placenta, spleen, prostate, testis, ovary (rat Svct2 also in lung, adrenal, osteoblast)
SLC23A3	SVCT3	YSPL1, FLJ31168, E2BP3
SLC23A4P	SVCT4

References
Original version of the SLC table:
Schnetkamp PP. The SLC24 gene family of Na(+)/Ca(2+)-K(+) exchangers: From sight and smell to memory consolidation and skin pigmentation. Mol Aspects Med. 2013 Apr;34(2-3):455-64.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC24A1	NCKX1	RODX, HsT17412, KIAA0702	E / 4 Na+, Ca2+, K+	Na+, Ca2+, K+	rod photoreceptors, platelets
SLC24A2	NCKX2		E / 4 Na+, Ca2+, K+	Na+, Ca2+, K+	brain, retinal cone, photoreceptors, retinal, ganglion cells
SLC24A3	NCKX3		E / 4 Na+, Ca2+, K+	Na+, Ca2+, K+	brain, aorta, uterus, intestine
SLC24A4	NCKX4	SHEP6, FLJ38852	E / 4 Na+, Ca2+, K+	Na+, Ca2+, K+	brain, olfactory neurons, aorta, lung, thymus
SLC24A5	NCKX5	JSX, SHEP4	E / 4 Na+, Ca2+, K+	Na+, Ca2+, K+	retina, brain, thymus, skin

References
Original version of the SLC table:
Palmieri F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Mol Aspects Med. 2013 Apr;34(2-3):465-84.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC25A1	CIC (citrate carrier)	CTP, tricarboxylate carrier, SLC20A3	E / citrate-H+, malate	citrate, isocitrate, malate, PEP	liver, kidney, pancreas, also in brain, lung, heart
SLC25A2	ORC2 (ornithine carrier 2)	ORNT2	E / ornithine, citrulline, H+; ornithine, H+	ornithine, citrulline, lysine, arginine, histidine	liver, testis, spleen, lung, pancreas, small intestine, brain, kidney
SLC25A3	PHC (phosphate carrier)	PTP, PiC	C / phosphate, H+; E / phosphate, OH-	phosphate	isoform A: heart, skeletal muscle, diaphragm; isoform B: liver, kidney, brain, thymus, lung, heart, skeletal muscle, diaphragm
SLC25A4	ANT1 (adenine nucleotide translocase-1)	AAC1, T1, PEO2, PEO3	E / ADP, ATP	ADP, ATP	heart, skeletal muscle, much less in brain, pancreas, prostate, kidney, lung, thymus
SLC25A5	ANT2 (adenine nucleotide translocase-2)	AAC2, T2	E / ADP, ATP	ADP, ATP	brain, lung, kidney, pancreas, heart, skeletal muscle, spleen
SLC25A5P1	pseudogene	bK250D10, ANTP3
SLC25A6	ANT3 (adenine nucleotide translocase-3)	AAC3, T3	E / ADP, ATP	ADP, ATP	brain, lung, kidney, liver, pancreas, heart, skeletal muscle, spleen, thymus
SLC25A6P1	pseudogene
SLC25A7	UCP1 (uncoupling protein 1)	thermogenin, proton carrier	F	H+	brown adipose tissue
SLC25A8	UCP2 (uncoupling protein 2)	proton carrier, UCPH	F	H+	lung, kidney, spleen, heart
SLC25A9	UCP3 (uncoupling protein 3)	proton carrier	F	H+	skeletal muscle, lung
SLC25A10	DIC (dicarboxylate carrier)		E / malate, phosphate	malate, phosphate, succinate, sulphate, thiosulphate	liver, kidney, heart, brain, lung, pancreas
SLC25A11	OGC (oxoglutarate carrier)	oxoglutarate / malate carrier, SLC20A4	E / oxoglutarate, malate	2-oxoglutarate, malate	heart, skeletal muscle, liver, kidney, brain, pancreas
SLC25A12	AGC1 (aspartate / glutamate carrier 1)	aralar1	E / aspartate, glutamate, H+	aspartate, glutamate	brain, heart, skeletal muscle, lung, pancreas, kidney, but not in liver
SLC25A13	AGC2 (aspartate / glutamate carrier 2)	citrin, CTLN2, aralar2	E / aspartate, glutamate, H+	aspartate, glutamate	liver, kidney, pancreas, heart, skeletal muscle, brain
SLC25A14	UCP5 (uncoupling protein 5)	BMCP1, brain mitochondrial carrier protein	O		widely expressed, with highest levels in brain and testis
SLC25A15	ORC1 (ornithine carrier 1)	ORNT1, HHH	E / ornithine, citrulline, H+; ornithine, H+	ornithine, citrulline, lysine, arginine	liver, pancreas, lung, testis, small intestine, spleen, kidney, brain, heart
SLC25A15P1	pseudogene
SLC25A16	GDC (Graves' disease carrier)	GDA, ML7, HGT.1	O		liver, kidney, thyroid, lung, heart, skeletal muscle, brain
SLC25A17		PMP34, ANC1, ANT1	E / CoA; PAP, CoA, dPCoA; CoA,AMP; FAD, FMN; NAD+, AMP	CoA, FAD, NAD+, AMP, ADP, PAP, dPCoA, FMN	brain, kidney, lung, heart, liver, pancreas
SLC25A18	GC2 (glutamate carrier 2)		C / glutamate, H+; E / glutamate, OH-	glutamate	brain, testis, heart, pancreas, kidney, lung
SLC25A19	DNC (deoxynucleotide carrier)	MUP1, TPC, MCPHA	E / thiamine pyrophosphate, thiamine monophosphate, thiamine; pyrophosphate, (deoxy)nucleotide	thiamine pyrophosphate, thiamine monophosphate, (deoxy)nucleotides	brain, testis, lung, kidney, liver, spleen, skeletal muscle, heart
SLC25A20	CAC (carnitine / acylcarnitine carrier)	CACT, carnitine carrier	E / carnitine, acylcarnitine; F (at slow rate)	carnitine, acylcarnitine	heart, skeletal muscle, liver, also in lung, kidney, brain, pancreas, lung, placenta
SLC25A20P1	pseudogene
SLC25A21	ODC (oxoadipate carrier)		E / oxoadipate, oxoglutarate	oxoadipate, oxoglutarate	kidney, gall bladder, colon, liver, placenta, testis, lung, spleen, skeletal muscle, brain, heart
SLC25A22	GC1 (glutamate carrier 1)		C / glutamate, H+; E / glutamate, OH-	glutamate	pancreas, brain, liver, testis, spleen, kidney, heart, lung, small intestine, pancreatic beta cells
SLC25A23	APC2	ScaMC-3, MCSC2	E / ATP-Mg, Pi	ATP-Mg2+, ATP, ADP, AMP, Pi	kidney, lung, small intestine, pancreas, brain, liver, skeletal muscle, heart
SLC25A24	APC1	ScaMC-1	E / ATP-Mg, Pi	ATP-Mg2+, ATP, ADP, AMP, Pi	testis
SLC25A25	APC3	ScaMC-2, MCSC, PCSCL	O		brain, heart, skeletal muscle, liver, small intestine, lung, pancreas, testis
SLC25A26	SAMC		E / S-adenosyl-methionine, S-adenosyl-homocysteine	S-adenosyl-methionine, S-adenosyl-homocysteine	ubiquitous (testis)
SLC25A27	UCP4 (uncoupling protein 4)		O		brain
SLC25A28	Mitoferrin 2 (Mfrn2)	MRS3 / 4, MRS4L		Fe2+	ubiquitous (heart, liver, kidney)
SLC25A29	ORNT3	CACL		ornithine, acylcarnitine	heart, skeletal muscle, liver, brain
SLC25A30		KMCP1, UCP6	O		kidney
SLC25A31	AAC4, ANT4 (adenine nucleotide carrier 4)	SFEC	E / ADP, ATP	ADP, ATP	testis
SLC25A32	MFT	MFTC		folate
SLC25A33	PNC1 (pyrimidine nucleotide carrier 1)	BMSC-MCP		UTP	ubiquitous
SLC25A34			O
SLC25A35			O
SLC25A36	PNC2 (pyrimidine nucleotide carrier 2)			pyrimidine nucleotides
SLC25A37	Mitoferrin 1 (Mfrn1)	HT015, MSC, MSCP		Fe2+	fetal liver, bone marrow, spleen, placenta, liver, brain
SLC25A38				glycine ?	erythroid cells
SLC25A39		CGI-69	O		ubiquitous
SLC25A40		MCFP	O		ubiquitous at low levels
SLC25A41	APC4	SCaMC-3L	E	ATP-Mg / Pi	brain, testis, liver
SLC25A42			E	CoA, ADP, ATP, adenosine 3',5'-diphosphate, dPCoA	ubiquitous (adipose tissue)
SLC25A43			O		brain, adrenal gland, skeletal muscle
SLC25A44			O		ubiquitous
SLC25A45			O		skeletal muscle, intestine, brain, testis
SLC25A46			O		ubiquitous
SLC25A47		C14orf68, HDMCP	O
SLC25A48		FLJ44862	O
SLC25A49	MTCH1	MCH1	O
SLC25A50	MTCH2	MCH2	O
SLC25A51	MCART1	MCTR1	O
SLC25A51P1	pseudogene	MCART3P
SLC25A51P2	pseudogene	MCART4P
SLC25A51P3	pseudogene	MCART5P
SLC25A52	MCART2	MCTR2	O
SLC25A53	MCART6	MCTR6	O

References
Original version of the SLC table:
Alper SL, Sharma AK. The SLC26 gene family of anion transporters and channels. Mol Aspects Med. 2013 Apr;34(2-3):494-515.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC26A1	SAT1, SLC26A1		E / SO42-, oxalate, glyoxylate	SO42-, oxalate, glyoxylate	hepatocytes, renal prox tubule, intestine
SLC26A2	DTDST, SLC26A2		E / SO42-, oxalate, Cl-	SO42-, oxalate, Cl-	chondrocytes, renal prox tubule, intestine, panc duct
SLC26A3	DRA, CLD, SLC26A3		E / Cl-, HCO3-, oxalate	Cl-, HCO3-, oxalate	enterocytes, sperrm, epididymis
SLC26A4	PDS, Pendrin, SLC26A4		E / I-, Cl-, HCO3-	I-, Cl-, HCO3-	cochlear, vestibular, epithelial cells, thyrocytes, type B intercalated cell, airway epithelial cell
SLC26A5	Prestin, SLC26A5		E / Cl-, formate, oxalate, SO42-	Cl-, formate, oxalate, SO42-	cochlear hair cells
SLC26A6	CFEX, PAT1, SLC26A6		E / Cl-, HCO3-, oxalate, OH-, formate	Cl-, HCO3-, oxalate, OH-, formate	enterocytes, pancreatic duct, renal prox tubule, cardiac myocytes, sperm
SLC26A7	SUT2, SLC26A7		E / Cl-, HCO3-, OH-, SO42-, Ch / Cl-	Cl-, HCO3-, OH-, SO42-, Ch: Cl-	gastric parietal cells, type A intercalated cells, endothelial cells
SLC26A8	TAT1, SLC26A8		E / Cl-, HCO3-, OH-	Cl-, HCO3-, OH-	male germ cells, sperm
SLC26A9	SLC26A9		E / Cl-, HCO3, Ch / Cl-, HCO3-	Cl-, HCO3, Ch: Cl-, HCO3-	airway epithelial cells, gastric parietal cells, kidney (cell type ?), brain
SLC26A10	(SLC26A10)				widespread (transcribed ?, pseudogene )
SLC26A11	SUT1, KBAT, SLC26A11		E / Cl-, HCO3-, SO42-, oxalate, ?Ch / Cl-	Cl-, HCO3-, SO42-, oxalate (?), Ch: Cl-	renal intercalated cells, panc duct, endothelial cells, brain, widespread

References
Original version of the SLC table:
Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Mol Aspects Med. 2013 Apr;34(2-3):516-28.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC27A1	FATP1	FATP, ACSVL5	LCFA transport, VLCFA activation	LCFA, VLCFA	BAT, WAT, heart, skeletal muscle, skin, brain, kidney, endothelial cells
SLC27A2	FATP2	ACSVL1, VLCS, VLACS, FACVL1	LCFA transport, VLCFA activation	LCFA, VLCFA	liver, kidney cortex, placenta
SLC27A3	FATP3	ACSVL3, VLCS-3	LCFA transport, VLCFA activation	LCFA, VLCFA	skin, adrenal gland, testis, ovary, brain, lung, endothelial cells
SLC27A4	FATP4	ACSVL4	LCFA transport, VLCFA activation	LCFA, VLCFA	small intestine, skin, placenta, brain, skeletal muscle, WAT, endothelial cells
SLC27A5	FATP5	ACSVL6, VLCS-H2, VLACSR, FACVL3, BAL, ACSB, BACS	LCFA transport, bile acid conjugation	LCFA, bile acids	liver
SLC27A6	FATP6	ACSVL2, VLCS-H1, FACVL2	LCFA transport, VLCFA activation	LCFA, VLCFA	heart, skin

References
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC28A1	CNT1		concentrative 1:1 sodium:nucleoside		kidney, liver, small intestine
SLC28A2	CNT2		concentrative 1:1 sodium:nucleoside		heart, skeletal muscle, liver, kidney, intestine, pancreas, placenta, brain
SLC28A3	CNT3		concentrative 2:1 sodium: nucleoside 1:1 proton: nucleoside probably 1:1:1 sodium:proton:nucleoside		widely expressed, most abundant in mammary gland, pancreas, bone marrow, trachea, intestine

References
Original version of the SLC table:
Young JD, Yao SY, Baldwin JM, Cass CE, Baldwin SA. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med. 2013 Apr;34(2-3):529-47.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC29A1	ENT1		F		widely expressed
SLC29A2	ENT2		F		particularly abundant in skeletal muscle but widely expressed
SLC29A3	ENT3		unclear, possibly proton-linked		widely expressed
SLC29A4	ENT4		unclear, possibly proton-linked		heart, brain, skeletal muscle

References
Original version of the SLC table:
Huang L, Tepaamorndech S. The SLC30 family of zinc transporters - A review of current understanding of their biological and pathophysiological roles. Mol Aspects Med. 2013 Apr;34(2-3):548-60.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC30A1		ZnT1			widespread
SLC30A2		ZnT2			mammary gland, prostate, retina, pancreas, small intestine, kidney
SLC30A3		ZnT3			brain, testes, pancreas
SLC30A4		ZnT4			widespread, predominant in mammary gland, placenta, prostate, brain, kidney
SLC30A5		ZnT5			widespread, predominant in heart, placenta, pancreas, prostate, ovary, testis, small intestine, thymus, bone
SLC30A6		ZnT6			widespread, predominant in brain, lung, intestine
SLC30A7		ZnT7			widespread, predominant intestine, stomach, prostate, retina, pancreas, testis, muscle
SLC30A8		ZnT8			pancreas, thyroid, adrenal gland, testis
SLC30A9		ZnT9			widespread
SLC30A10		ZnT10			brain, retina, liver

References
Original version of the SLC table:
Kim H, Wu X, Lee J. SLC31 (CTR) family of copper transporters in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):561-70.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC31A1	CTR1	hCtr1, Ctr1, COPT1	energy in-dependent, potassium-dependent	copper (I), cisplatin	ubiquitous mRNA expression, highest in the liver, lowest in the brain, skeletal muscle
SLC31A1P1	pseudogene	SLC31A1P, CTR1psi, CTR1P
SLC31A2	CTR2	hCtr2, Ctr2, COPT2	unknown	copper, cisplatin	ubiquitous mRNA expression

References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC32A1	VIAAT	VGAT	E / H+	GABA / glycine	CNS

References
Original version of the SLC table:
Hirabayashi Y, Nomura KH, Nomura K. The acetyl-CoA transporter family SLC33. Mol Aspects Med. 2013 Apr;34(2-3):586-9.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC33A1	ACATN1	AT-1	F	acetyl-CoA	brain, spinal cord, prostate, placenta, uterus, testis, thymus, trachea
SLC33A2	MFSD3				Neurons [PMID: 27981419]

References
Original version of the SLC table:
Forster IC, Hernando N, Biber J, Murer H. Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med. 2013 Apr;34(2-3):386-95.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC34A1	NaPi-IIa	Napi-3, NPT2, npt2	C / Na, HPO42-	inorganic phosphate (divalent)	kidney (proximal tubule), osteoclasts, neurons
SLC34A2	NaPi-IIb		C / Na, HPO42-	inorganic phosphate (divalent)	small intestine, lung, testis, liver, secreting mammary gland
SLC34A3	NaPi-IIc		C / Na, HPO42-	inorganic phosphate (divalent)	kidney (proximal tubule)

References
Original version of the SLC table:
Song Z. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. Mol Aspects Med. 2013 Apr;34(2-3):590-600.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC35A1	CST	CMPST	E / CMP	CMP-sialic acid	ubiquitous
SLC35A2	UGT	UGAT, UGTL, UGALT, UGT1, UGT2	E / UMP	UDP-galactose, UDP-N-acetylgalactosamine	ubiquitous
SLC35A3		DKFZp781P1297	E / UMP	UDP-N-acetylglucosamine	ubiquitous
SLC35A4		MGC2541			ubiquitous
SLC35A5		FLJ11130, FLJ20730, FLJ25973, DKFZp434E102			ubiquitous
SLC35B1		UGTREL1			ubiquitous
SLC35B2	PAPST1	UGTrel4, SLL		PAPS	ubiquitous
SLC35B3	PAPST2	CGI-19, C6orf196		PAPS	ubiquitous
SLC35B4	YEA	YEA4, FLJ14697		UDP-xylose, UDP-N-acetylglucosamine	ubiquitous
SLC35C1	FUCT1	FLJ11320, FLJ14841	E / GMP	GDP-fucose	ubiquitous
SLC35C2	OVCOV1	CGI-15, C20orf5, FLJ37039, FLJ46434, MGC20633, MGC32079, MGC39183, BA394O2.1		GDP-fucose (?)	ubiquitous
SLC35D1	UGTREL7	KIAA0260, MGC138236	E / UMP	UDP-glucuronic acid, UDP-N-acetylgalactosamine	ubiquitous, high in colon, stomach, lung, leukocytes
SLC35D2	HFRC1	UGTrel8, Hfrc, SQV7L, MGC117215, MGC142139		UDP-N-acetylglucosamine	ubiquitous, high in colon, stomach, lung, leukocytes
SLC35D3	FRCL1	MGC102873, bA55K22.3			retina
SLC35D4	TMEM241	C18orf45
SLC35E1		FLJ14251, FLJ36689, MGC44954, DKFZp564G0462			ubiquitous
SLC35E2A	pseudogene	FLJ34996, FLJ44537, KIAA0447, MGC104754, MGC117254, MGC126715, MGC138494, DKFZp686M0869
SLC35E2B			N/D	N/D	N/D
SLC35E3		BLOV1			ubiquitous
SLC35E4		MGC129826			ubiquitous
SLC35F1		C6orf169, FLJ13018, dJ230I3.1			brain
SLC35F2		HSNOV1, FLJ13018, DKFZp667H1615			salivary gland
SLC35F3		FLJ37712			cerebellum
SLC35F4		C14orf36, FLJ37712, c14_5373			cerebellum
SLC35F5		FLJ22004			ubiquitous
SLC35F6	C2orf18	ANT2BP
SLC35G1		TMEM20, C10orf60
SLC35G2		TMEM22
SLC35G3		AMAC1, TMEM21A
SLC35G4		AMAC1L1
SLC35G5		AMAC, AMAC1L2
SLC35G6		AMAC1L3, TMEM21B

References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC36A1	PAT1	LYAAT1	C / H+	GABA, P, G, beta-alanine	brain, intestine, colon, kidney, lung, liver, spleen
SLC36A2	PAT2	tamodorin 1	C / H+	P, G, A, hydroxyproline	lung, heart, kidney, muscle, testis, spleen, adrenal gland, thymus, sciatic nerve
SLC36A3	PAT3				testes
SLC36A4	PAT4	LYAAT2	C / H+	P, tryptophan	ubiquitous

References
Original version of the SLC table:
Chou JY, Sik Jun H, Mansfield BC. The SLC37 family of phosphate-linked sugar phosphate antiporters. Mol Aspects Med. 2013 Apr;34(2-3):601-11.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC37A1	SLC37A1, SPX1	glucose-6-phosphate	E / inorganic phosphate		ubiquitous, high levels in prostate, pancreas, thymus, bone marrow, spleen
SLC37A2	SLC37A2, SPX2	glucose-6-phosphate	E / inorganic phosphate		ubiquitous, high levels in spleen, thymus, bone marrow, prostate, lung, pancreas, liver, kidney, macrophages
SLC37A3	SLC37A3, SPX3	unknown			ubiquitous, high levels in spleen, thymus, bone marrow, lung, brain, prostate, pancreas
SLC37A4	SLC37A4, G6PT, SPX4	glucose-6-phosphate	E / inorganic phosphate		ubiquitous, high levels in liver, kidney, prostate, pancreas, thymus, bone marrow, spleen

References
Original version of the SLC table:
Schiöth HB, Roshanbin S, Hägglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013 Apr;34(2-3):571-85.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC38A1	SNAT1	ATA1, NAT2, SAT1	C / Na+	Q, A, N, C, H, S	brain, retina, heart, placenta, adrenal gland
SLC38A2	SNAT2	ATA2, SAT2	C / Na+	A, N, C, Q, G, H, M, P, S	ubiquitous
SLC38A3	SNAT3	SN1	C / Na+, E / H+	Q, H, A, N	liver, skeletal muscle, kidney, pancreas
SLC38A4	SNAT4	ATA3, NAT3, PAAT	C / Na+	A, N, C, G, S, T	brain, retina, liver, kidney, adipose tissue
SLC38A5	SNAT5	SN2	C / Na+, E / H+	Q, N, H, S	stomach, brain, liver, lung, small intestine, spleen, colon, kidney
SLC38A6	SNAT6				brain, eye, heart, liver, kidney
SLC38A7	SNAT7		? / Na+	Q, H, S ,A, N	brain, liver, skeletal muscle, uterus, pituitary
SLC38A8	SNAT8		? / Na+	Q, H, A, N [PMID: 25451601]	brain, pituitary, thymus, stomach, adrenal gland
SLC38A9	N/A			R, Q, H, P, K, E, L	ubiquitous
SLC38A10	N/A				brain, pituitary, lung, kidney, liver
SLC38A11	N/A				testes, stomach, skeletal muscle, pituitary, adrenal gland

References
Original version of the SLC table:
Jeong J, Eide DJ. The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr;34(2-3):612-9.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC39A1	ZIP1, ZIRTL			Zn	widespread
SLC39A2	ZIP2, Eti-1, 6A1			Zn	widespread
SLC39A3	ZIP3			Zn, not specific	widespread, mammary cells, testis
SLC39A4	ZIP4			Zn	gastrointestinal tract, kidney hippocampal neurons
SLC39A5	ZIP5, LZT-Hs7			Zn	pancreas, kidney, liver, stomach, intestine
SLC39A6	ZIP6, LIV-1			Zn	widespread
SLC39A7	ZIP7, HKE4, RING5			Zn, Mn	widespread
SLC39A8	ZIP8, BIGM103, LZT-Hs6			Zn, Cd, Mn	widespread, T-cells, erythroid, testis
SLC39A9	ZIP9
SLC39A10	ZIP10, LZT-Hs2			Zn	brain, liver, erythroid, kidney
SLC39A11	ZIP11
SLC39A12	ZIP12j, LZT-Hs8			Zn	brain, lung, testis, retina
SLC39A13	ZIP13, LZT-Hs9			Zn	widespread
SLC39A14	ZIP14, LZT-Hs4			Zn, Fe, Mn, Cd	widespread, liver

References
Original version of the SLC table:
Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013 Apr;34(2-3):270-87.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC40A1	ferroportin (FPN1)	MTP1, IREG1	F ?	ferrous iron	duodenum, macrophages, liver Kupffer cells, placenta, kidney

References
Original version of the SLC table:
Sahni J, Scharenberg AM. The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr;34(2-3):620-8.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC41A1	MgtE		Ch	Mg2+ (Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, Cd2+)	kidney, heart, testis, skeletal muscle, prostate, adrenal gland, thyroid
SLC41A2		SLC41A1-L1, SLC41A1-like 1	Ch	Mg2+ (Ba2+, Ni2+, Co2+, Fe2+, Mn2+)	highest expression in cerebellum, lymph nodes, stomach, lungs, testis, skin
SLC41A3		SLC41A1-L2, SLC41A1-like 2, FLJ20473	Ch? (predicted based on homology with the other 2 members/MgtE transporter)

References
Original version of the SLC table:
Nakhoul NL, Lee Hamm L. Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport. Mol Aspects Med. 2013 Apr;34(2-3):629-37.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC42A1	RhAG	RHAG (Rh50A)	H+	NH4+, NH3	red blood cells
SLC42A2	RhBG	RHBG	electrogenic, no coupled ions	NH4+, NH3, methyl amine, methyl ammonium	kidney, liver, skin, GI tract, sweat glands, ovaries
SLC42A3	RhCG	RHCG (RhGK)	electroneutral, possibly H+	NH4+, NH3	kidney, brain, testis, placents, pancreas, prostate

References
Original version of the SLC table:
Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palacín M. The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med. 2013 Apr;34(2-3):638-45.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC43A1	LAT3	POV1	F	L-BCAAs, amino alcohols	liver, skeletal muscle, placenta, kidney podocytes
SLC43A2	LAT4		F	L-BCAAs, amino alcohols	placenta, kidney, peripheral blood leukocytes, small intestine
SLC43A3	EEG1	FOAP-13	O		liver, heart, lung, kidney

References
Original version of the SLC table:
Traiffort E, O'Regan S, Ruat M. The choline transporter-like family SLC44: Properties and roles in human diseases. Mol Aspects Med. 2013 Apr;34(2-3):646-54.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC44A1	CTL1	CDw92, CHTL1	E?	choline	brain and spinal cord neurons and oligodendrocytes, colon (mucosal cells), lung, numerous tumoral or non-tumoral cell lines
SLC44A2	CTL2	PP1292	O	choline	tongue, muscle, kidney, heart, lung, testis, intestine stomach, inner ear (vestibular supporting cells)
SLC44A3	CTL3	MGC45474	O		kidney, ileum, colon
SLC44A4	CTL4	NG22, FLJ14491	O		intestine, stomach, kidney
SLC44A5	CTL5	MGC34032	O		brain, spinal cord

References
Original version of the SLC table:
Vitavska O, Wieczorek H. The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr;34(2-3):655-60.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC45A1	SLC45A1	Past-A, DNB5	C / H+	glucose, galactose, sucrose	brain, fetal kidney
SLC45A2	SLC45A2	MATP, AIM1, underwhite	C / H+ [PMID: 25164149]	sucrose, glucose, fructose [PMID: 25164149]	skin, eye, melanocyte
SLC45A3	SLC45A3	Prostein	C / H+ [PMID: 25164149]	sucrose, glucose, fructose [PMID: 25164149]	prostate, kidney [PMID: 27228996], liver, uterus, brain
SLC45A4	SLC45A4	KIAA1126	C / H+ [PMID: 25164149]	sucrose, glucose, fructose [PMID: 25164149]	ubiquitous, with maxima in brain, spinal marrow and testis

References
Original version of the SLC table:
Zhao R, Goldman ID. Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr;34(2-3):373-85.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC46A1	PCFT	HCP1	C / proton-symporter	Reduced folates, folic acid, antifolates	small intestine, choroid plexus, kidney (proximal tubule), liver (sinusoidal), placenta
SLC46A2	TSCOT	Ly110		unknown	Thymus, epididymis
SLC46A3				Uncertain; lysosomal export of maytansine conjugates	Ubiquitous

References
Original version of the SLC table:
Motohashi H, Inui K. Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med. 2013 Apr;34(2-3):661-8.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC47A1		MATE1		tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, metformin, guanidine, procainamide, cephalexin, cephradine	liver, kidney, muscle
SLC47A2		MATE2-K (MATE2, MATE2-B)		TEA, MPP, cimetidine, metformin, guanidine, procainamide	kidney (MATE2-K)

References
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC48A1	HRG-1		C / H+ ?	heme	liver, heart, CNS, kidney, skeletal muscle, small intestine

References
Original version of the SLC table:
Khan AA, Quigley JG. Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med. 2013 Apr;34(2-3):669-82.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC49A1	FLVCR1	FLVCR, MFSD7B, AXPC1, PCARP	unknown	heme	ubiquitous, high expression in intestine, liver, kidney, brain, bone marrow
SLC49A2	FLVCR2	MFSD7C, CCT, EPV, PVHH, FLVCRL14q	unknown	heme	liver, kidney, brain, lung, placenta, fetal liver, bone marrow
SLC49A3	MFSD7	LP2561, FLJ22269	unknown	unknown	pancreas, spleen, brain, lung, ovary, breast
SLC49A4	DIRC2	RCC4, FLJ14784	unknown	unknown	pancreas, kidney, liver, placenta, heart

References
Original version of the SLC table:
Wright EM. Glucose transport families SLC5 and SLC50. Mol Aspects Med. 2013 Apr;34(2-3):183-96.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC50A1	RAG1AP	HsSWEET1	F	glucose	ubiquitous expression, with highest expression in oviduct, epididymis, intestine

References
Original version of the SLC table:
Ballatori N, Christian WV, Wheeler SG, Hammond CL. The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: A transporter for steroid-derived molecules. Mol Aspects Med. 2013 Apr;34(2-3):683-92.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC51A	OST alpha	OST alpha-OST beta	F	bile acids	intestine
SLC51B	OST beta			steroids	liver, kidney, testes, ovary, adrenal gland

References
Original version of the SLC table:
Yonezawa A, Inui K. Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52. Mol Aspects Med. 2013 Apr;34(2-3):693-701.

SLC name	Protein name	Aliases	Transport type*	Substrates	Tissue and cellular expression
SLC52A1		RFVT1, RFT1, GPR172B, PERV-A receptor 2, GPCR42, PAR2, FLJ10060	Na+, Cl-, pH-independent		placenta > small intestine, etc
SLC52A2		RFVT2, RFT3, GPR172A, PERV-A receptor 1, GPCR41, PAR1, D15Ertd747e, FLJ11856	Na+, Cl-, pH-independent		brain > salivary gland > several tissues
SLC52A3		RFVT3, RFT2, C20orf54, RIKEN cDNA 2310046K01, hypothetical protein LOC113278, bA371L19.1	C / Na+, Cl-indep., pH sensitive		testis > small intestine > prostate, etc