Protein name: xCT Aliases: [4F2hc], system xc- Substrates: cystine (anionic form), L-glutamate Transport type: Exchanger (preferentially extracellular cystine against intracellular glutamate) Tissue and cellular expression: macrophages, brain, retinal pigment cells, liver, kidney Subcellular expression: basolateral in epithelial cells Disease: N/D Locus: 4q28.3 Sequence ID: NP_055146.1, NM_014331.3 Gene ID: 23657 Splice variants: N/D


Gene names: SLC7A11
Protein names and data: XCT_HUMAN, Full=Cystine/glutamate transporter, Full=Amino acid transport system xc-;Full=Calcium channel blocker resistance protein CCBR1;Full=Solute carrier family 7 member 11;Full=xCT; Length: 501 a.a., Mass: 55423 Da,
fasta formatted sequence

Function: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q9UPY5
NextBio: 46497
OMIM: 607933
Ensembl: ENST00000280612
GeneCard: GC04M138164
PharmGenUCSF: SLC7A11
Guide to Pharmacology: SLC7A11 (902)
SLC7 family (902)

HGNC: HGNC:11059

Genetic variants

See also Ensembl:ENST00000280612