Protein name: ENT4 Aliases: N/D Substrates: N/D Transport type: unclear, possibly proton-linked Tissue and cellular expression: heart, brain, skeletal muscle Subcellular expression: primarily plasma membrane-located Disease: N/D Locus: 7p22.1 Sequence ID: NP_001035751.1, NM_001040661.1 NP_694979.2, NM_153247.2 Gene ID: 222962 Splice variants: N/D

S29A4_HUMAN (UniProt)

Gene names: SLC29A4, ENT4, PMAT, PSEC0113
Protein names and data: S29A4_HUMAN, Full=Equilibrative nucleoside transporter 4;Short=hENT4, Full=Plasma membrane monoamine transporter;Full=Solute carrier family 29 member 4; Length: 530 a.a., Mass: 58059 Da,
fasta formatted sequence

Function: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia
Cellular location: Cell membrane; Multi-pass membrane protein (Potential). Apical cell membrane; Multi-pass membrane protein (Potential). Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells
Tissue specificity: Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase

Database cross-references

UniProt: Q7RTT9
NextBio: 91692
OMIM: 609149
Ensembl: ENST00000406453
GeneCard: GC07P005289
TCDB: 2.A.57.1.5
PharmGenUCSF: SLC29A4
Guide to Pharmacology: SLC29A4 (1120)
SLC29 family (1120)

HGNC: HGNC:23097

Genetic variants

See also Ensembl:ENST00000406453