Protein name: LAT3 Aliases: POV1 Substrates: L-BCAAs, amino alcohols Transport type: Facilitated transporter Tissue and cellular expression: liver, skeletal muscle, placenta, kidney podocytes Subcellular expression: N/D Disease: expression in androgen-dependent cancers Locus: 11q12.1 Sequence ID: NP_001185739.1, NM_001198810.1 NP_003618.1, NM_003627.5 Gene ID: 8501 Splice variants: two 5? UTR variants

LAT3_HUMAN (UniProt)

Gene names: SLC43A1, LAT3, PB39, POV1
Protein names and data: LAT3_HUMAN, Full=Large neutral amino acids transporter small subunit 3, Full=L-type amino acid transporter 3;Full=Prostate cancer overexpressed gene 1 protein;Full=Solute carrier family 43 member 1; Length: 559 a.a., Mass: 61477 Da,
fasta formatted sequence

Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer
Cellular location: Membrane; Multi-pass membrane protein (Probable)
Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells

Database cross-references

UniProt: O75387
NextBio: 31811
OMIM: 603733
Ensembl: ENST00000528450
GeneCard: GC11M057502
TCDB: 2.A.1.44.1
PharmGenUCSF: SLC43A1
Guide to Pharmacology: SLC43A1 (1201)
SLC43 family of large neutral amino acid transporters (1201)


Genetic variants

See also Ensembl:ENST00000528450