Protein name: NDCBE Aliases: kNBC3 Substrates: sodium bicarbonate chloride Transport type: Cotransporter, E Tissue and cellular expression: brain, testes, kidney, ovary Subcellular expression: N/D Disease: N/D Locus: 12q13 Sequence ID: NP_001035049.1, NM_001039960.1 NP_001245330.1, NP_001245331.1, NP_001245332.1, NP_001254544.1, Gene ID: 9498 Splice variants: 4 splice variants

S4A8_HUMAN (UniProt)

Gene names: SLC4A8, KIAA0739, NBC, NBC3, NDCBE1
Protein names and data: S4A8_HUMAN, Full=Electroneutral sodium bicarbonate exchanger 1, Full=Electroneutral Na(+)-driven Cl-HCO3 exchanger;Full=Solute carrier family 4 member 8;Full=k-NBC3; Length: 1093 a.a., Mass: 122938 Da,
fasta formatted sequence

Function: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex

Database cross-references

UniProt: Q2Y0W8
NextBio: 35584
OMIM: 605024
Ensembl: ENST00000551071
GeneCard: GC12P051391
TCDB: 2.A.31.2.4
PharmGenUCSF: SLC4A8
Guide to Pharmacology: SLC4A8 (912)
Sodium-dependent HCO3- transporters (912)

HGNC: HGNC:11034

Genetic variants

See also Ensembl:ENST00000551071