Protein name: OATP1C1 Aliases: N/D Substrates: T4, T3, rT3 Transport type: N/D Tissue and cellular expression: brain (blood-brain barrier), testis (Leydig cells) Subcellular expression: N/D Disease: N/D Locus: 12p12.2 Sequence ID: NP_001139416.1, NM_001145944.1 NP_001139417.1, NM_001145945.1 NP_001139418.1, NM_001145946.1 NP_059131.1, NM_017435.4 Gene ID: 53919 Splice variants: 4 splice variants

SO1C1_HUMAN (UniProt)

Gene names: SLCO1C1, OATP14, OATP1C1, OATPF, SLC21A14
Protein names and data: SO1C1_HUMAN, Full=Solute carrier organic anion transporter family member 1C1, Full=Organic anion transporter F;Short=OATP-F;Full=Organic anion transporter polypeptide-related protein 5;Short=OAT-RP-5;Short=OATPRP5;Full=Organic anion-transporting polypeptide 14;Short=OATP-14;Full=Solute carrier family 21 member 14;Full=Thyroxine transporter; Length: 712 a.a., Mass: 78696 Da,
fasta formatted sequence

Function: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity)
Tissue specificity: Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels

Database cross-references

UniProt: Q9NYB5
NextBio: 56236
OMIM: 613389
Ensembl: ENST00000540354
GeneCard: GC12P020695
TCDB: 2.A.60.1.15
Guide to Pharmacology: SLCO1C1 (1222)
SLCO family of organic anion transporting polypeptides (1222)

HGNC: HGNC:13819

Genetic variants

See also Ensembl:ENST00000540354