Protein name: MCT1, Aliases: MOT1 Substrates: lactate, pyruvate, ketone bodies Transport type: Cotransporter / H+ or E / monocarboxylate Tissue and cellular expression: ubiquitous except beta cells of endocrine pancreas Subcellular expression: N/D Disease: exercise-induced hyperinsulin-aemia hypo-glycaemia Locus: 1p12 Sequence ID: NP_001159968.1, NM_001166496.1 NP_003042.3, NM_003051.3 Gene ID: 6566 Splice variants: splice variants in non-coding region

MOT1_HUMAN (UniProt)

Gene names: SLC16A1, MCT1
Protein names and data: MOT1_HUMAN, Full=Monocarboxylate transporter 1;Short=MCT 1, Full=Solute carrier family 16 member 1; Length: 500 a.a., Mass: 53944 Da,
fasta formatted sequence

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Widely expressed in normal and in cancer cells

Database cross-references

UniProt: P53985
NextBio: 25547
OMIM: 245340 600682 610021
Ensembl: ENST00000538576
GeneCard: GC01M112912
TCDB: 2.A.1.13.1
PharmGenUCSF: SLC16A1
Guide to Pharmacology: SLC16A1 (988)
SLC16 family of monocarboxylate transporters (988)

HGNC: HGNC:10922

Genetic variants

See also Ensembl:ENST00000538576