Protein name: OST alpha Aliases: OST alpha-OST beta Substrates: bile acids Transport type: Facilitated transporter Tissue and cellular expression: intestine Subcellular expression: basolateral membrane Disease: N/D Locus: 3q29 Sequence ID: NP_689885.4, NM_152672.5 Gene ID: 200931 Splice variants: N/D


Gene names: SLC51A, OSTA
Protein names and data: OSTA_HUMAN, Full=Organic solute transporter subunit alpha;Short=OST-alpha, Full=Solute carrier family 51 subunit alpha; Length: 340 a.a., Mass: 37735 Da,
fasta formatted sequence

Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids
Cellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transported from the endoplasmic reticulum to the plasma membrane once interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat

Database cross-references

UniProt: Q86UW1
NextBio: 90016
OMIM: 612084
GeneCard: GC03P196211
TCDB: 2.A.82.1.2
Guide to Pharmacology: SLC51A (1915)
SLC51 family of steroid-derived molecule transporters (1915)

HGNC: HGNC:29955

Genetic variants