SLCO1B3

Protein name: OATP1B3 Aliases: N/D Substrates: bile salts, organic anions Transport type: N/D Tissue and cellular expression: liver (hepatocytes) Subcellular expression: N/D Disease: unconjugated hyperbilirubinemia, Rotor syndrome Locus: 12p12 Sequence ID: NP_062818.1, NM_019844.3 Gene ID: 28234 Splice variants: N/D

SO1B3_HUMAN (UniProt)

Gene names: SLCO1B3 , LST2, OATP1B3, OATP8,SLC21A8
Protein names and data: SO1B3_HUMAN , Full=Solute carrier organic anion transporter family member 1B3 , Full=Liver-specific organic anion transporter 2;Short=LST-2;Full=Organic anion transporter 8;Full=Organic anion-transporting polypeptide 8;Short=OATP-8;Full=Solute carrier family 21 member 8; Length: 702 a.a., Mass: 77403 Da,
fasta formatted sequence

Function: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver
Disease:
Cellular location: Basolateral cell membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder

Database cross-references

UniProt: Q9NPD5
NextBio: 50556
OMIM: 237450 605495
Ensembl: ENST00000381545
GeneCard: GC12P020963
TCDB: 2.A.60.1.12
PharmGenUCSF: SLCO1B3
Guide2Pharmacology: 238
HGNC: HGNC:10961

Genetic variants

See also Ensembl:ENST00000381545