Protein name: Mitoferrin 2 (Mfrn2) Aliases: MRS3 / 4, MRS4L Substrates: Fe2+ Transport type: N/D Tissue and cellular expression: ubiquitous (heart, liver, kidney) Subcellular expression: N/D Disease: N/D Locus: 10q23-q24 Sequence ID: NP_112489.3, NM_031212.3 Gene ID: 81894 Splice variants: N/D


Gene names: SLC25A28, MFRN2, NPD016
Protein names and data: MFRN2_HUMAN, Full=Mitoferrin-2, Full=Mitochondrial RNA-splicing protein 3/4 homolog;Short=MRS3/4;Short=hMRS3/4;Full=Mitochondrial iron transporter 2;Full=Solute carrier family 25 member 28; Length: 364 a.a., Mass: 39272 Da,
fasta formatted sequence

Function: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity)
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion
Tissue specificity: Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart

Database cross-references

UniProt: Q96A46
NextBio: 72253
OMIM: 609767
Ensembl: ENST00000434701
GeneCard: GC10M099610
PharmGenUCSF: SLC25A28
Guide to Pharmacology: SLC25A28 (1080)
Miscellaneous SLC25 mitochondrial transporters (1080)

HGNC: HGNC:23472

Genetic variants

See also Ensembl:ENST00000434701