Protein name: FLVCR2 Aliases: MFSD7C, CCT, EPV, PVHH, FLVCRL14q Substrates: heme Transport type: unknown Tissue and cellular expression: liver, kidney, brain, lung, placenta, fetal liver, bone marrow Subcellular expression: located on the plasma membrane Disease: Fowler syndrome Locus: 14q24.3 Sequence ID: NP_001182212.1, NM_001195283.1 NP_060261.2, NM_017791.2 Gene ID: 55640 Splice variants: a variant transcript differs in the 5'-UTR and uses an alternate start codon, which should encode a shorter hypothetical protein


Gene names: FLVCR2, C14orf58
Protein names and data: FLVC2_HUMAN, Full=Feline leukemia virus subgroup C receptor-related protein 2, Full=Calcium-chelate transporter;Short=CCT; Length: 526 a.a., Mass: 57241 Da,
fasta formatted sequence

Function: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells of the pituitary that secrete growth hormone and prolactin

Database cross-references

UniProt: Q9UPI3
NextBio: 60326
OMIM: 225790 610865
Ensembl: ENST00000539311
GeneCard: GC14P075578
Guide to Pharmacology: SLC49A2 (1911)
SLC49 family of FLVCR-related heme transporters (1911)

HGNC: HGNC:20105

Genetic variants

See also Ensembl:ENST00000539311