Protein name: ferroportin (FPN1) Aliases: MTP1, IREG1 Substrates: ferrous iron Transport type: Facilitated transporter ? Tissue and cellular expression: duodenum, macrophages, liver Kupffer cells, placenta, kidney Subcellular expression: basolateral (duodenum) Disease: hemochromatosis type 4, breast cancer Locus: 2q32 Sequence ID: NP_055400.1, NM_014585.5 Gene ID: 30061 Splice variants: FPN1B, specifically expressed in the duodenal enterocytes and in erythroid precursor cells

S40A1_HUMAN (UniProt)

Gene names: SLC40A1, FPN1, IREG1, SLC11A3, MSTP079
Protein names and data: S40A1_HUMAN, Full=Solute carrier family 40 member 1, Full=Ferroportin-1;Full=Iron-regulated transporter 1; Length: 571 a.a., Mass: 62542 Da,
fasta formatted sequence

Function: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)
Cellular location: Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells
Tissue specificity: Expressed in placenta, intestine, muscle and spleen

Database cross-references

UniProt: Q9NP59
NextBio: 52848
OMIM: 604653 606069
Ensembl: ENST00000261024
GeneCard: GC02M189560
PharmGenUCSF: SLC40A1
Guide to Pharmacology: SLC40A1 (1194)
SLC40 iron transporter (1194)

HGNC: HGNC:10909

Genetic variants

See also Ensembl:ENST00000261024