Protein name: RhCG Aliases: RHCG (RhGK) Substrates: NH4+, NH3 Transport type: electroneutral, possibly H+ Tissue and cellular expression: kidney, brain, testis, placents, pancreas, prostate Subcellular expression: apical membrane (kidney) Disease: renal distal, tubular acidosis (?) Locus: 15q25 Sequence ID: NP_057405.1, NM_016321.1 Gene ID: 51458 Splice variants: N/D


Gene names: RHCG, C15orf6, CDRC2, PDRC2, RHGK
Protein names and data: RHCG_HUMAN, Full=Ammonium transporter Rh type C, Full=Rh glycoprotein kidney;Full=Rhesus blood group family type C glycoprotein;Short=Rh family type C glycoprotein;Short=Rh type C glycoprotein;Full=Tumor-related protein DRC2; Length: 479 a.a., Mass: 53179 Da,
fasta formatted sequence

Function: Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion
Cellular location: Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles (By similarity)
Tissue specificity: Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney

Database cross-references

UniProt: Q9UBD6
NextBio: 55075
OMIM: 605381
Ensembl: ENST00000268122
GeneCard: GC15M089471
TCDB: 1.A.11.4.1
Guide to Pharmacology: SLC42A3 (1200)
SLC42 family of Rhesus glycoprotein ammonium transporters (1200)

HGNC: HGNC:18140

Genetic variants

See also Ensembl:ENST00000268122