Protein name: Mitoferrin 1 (Mfrn1) Aliases: HT015, MSC, MSCP Substrates: Fe2+ Transport type: N/D Tissue and cellular expression: fetal liver, bone marrow, spleen, placenta, liver, brain Subcellular expression: N/D Disease: N/D Locus: 8p21.2 Sequence ID: NP_057696.2, NM_016612.2 Gene ID: 51312 Splice variants: N/D


Gene names: SLC25A37, MFRN, MSCP, HT015
Protein names and data: MFRN1_HUMAN, Full=Mitoferrin-1, Full=Mitochondrial iron transporter 1;Full=Mitochondrial solute carrier protein;Full=Solute carrier family 25 member 37; Length: 338 a.a., Mass: 37323 Da,
fasta formatted sequence

Function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity)
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)

Database cross-references

UniProt: Q9NYZ2
NextBio: 54651
OMIM: 610387
Ensembl: ENST00000519973
GeneCard: GC08P023528
PharmGenUCSF: SLC25A37
Guide to Pharmacology: SLC25A37 (1088)
Miscellaneous SLC25 mitochondrial transporters (1088)

HGNC: HGNC:29786

Genetic variants

See also Ensembl:ENST00000519973