Protein name: FATP2 Aliases: ACSVL1, VLCS, VLACS, FACVL1 Substrates: LCFA, VLCFA Transport type: LCFA transport, VLCFA activation Tissue and cellular expression: liver, kidney cortex, placenta Subcellular expression: N/D Disease: unknown Locus: 15q21.2 Sequence ID: NP_001153101.1, NM_001159629.1 NP_003636.2, NM_003645.3 Gene ID: 11001 Splice variants: variant 1 encodes the full-length protein, variant 2 lacks an in-frame coding exon, resulting in a shorter isoform missing an internal protein segment

S27A2_HUMAN (UniProt)

Gene names: SLC27A2, ACSVL1, FACVL1, FATP2, VLACS
Protein names and data: S27A2_HUMAN, Full=Very long-chain acyl-CoA synthetase;Short=VLACS;Short=VLCS;EC=6.2.1.-, Full=Fatty acid transport protein 2;Short=FATP-2;Full=Fatty-acid-coenzyme A ligase, very long-chain 1;Full=Long-chain-fatty-acid--CoA ligase;EC=;Full=Solute carrier family 27 member 2;Full=THCA-CoA ligase;Full=Very long-chain-fatty-acid-CoA ligase; Length: 620 a.a., Mass: 70312 Da,
fasta formatted sequence

Function: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
Catalytic activity: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes
Tissue specificity: Expressed in liver, kidney, placenta and pancreas

Database cross-references

UniProt: O14975
NextBio: 41795
OMIM: 603247
Ensembl: ENST00000380902
GeneCard: GC15P050182
TCDB: 4.C.1.1.5
PharmGenUCSF: SLC27A2
Guide to Pharmacology: SLC27A2 (1109)
SLC27 family of fatty acid transporters (1109)

HGNC: HGNC:10996

Genetic variants

See also Ensembl:ENST00000380902