Protein name: VGLUT2 Aliases: DNPI Substrates: glutamate Transport type: electrogenic, Cl- dependent Tissue and cellular expression: brain (neurons only), endocrine Subcellular expression: synaptic vesicle Disease: none Locus: 11p14.3 Sequence ID: NP_065079.1, NM_020346.2 Gene ID: 57084 Splice variants: N/D


Gene names: SLC17A6, DNPI, VGLUT2
Protein names and data: VGLU2_HUMAN, Full=Vesicular glutamate transporter 2;Short=VGluT2, Full=Differentiation-associated BNPI;Full=Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter;Full=Solute carrier family 17 member 6; Length: 582 a.a., Mass: 64392 Da,
fasta formatted sequence

Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate
Cellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (By similarity). Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome (By similarity)
Tissue specificity: Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus

Database cross-references

UniProt: Q9P2U8
NextBio: 62871
OMIM: 607563
Ensembl: ENST00000263160
GeneCard: GC11P022359
PharmGenUCSF: SLC17A6
Guide to Pharmacology: SLC17A6 (1008)
Vesicular glutamate transporters (VGLUTs) (1008)

HGNC: HGNC:16703

Genetic variants

See also Ensembl:ENST00000263160