Protein name: b0,+AT Aliases: [rBAT], system b0,+ Substrates: cationic amino acids, large neutral amino acids Transport type: Exchanger (preferentially extracellular cationic amino acid and cystine against intracellular neutral amino acid) Tissue and cellular expression: kidney, small intestine, liver, placenta Subcellular expression: apical in epithelial cells Disease: cystinuria, isolated cystinuria Locus: 19q13.1 Sequence ID: NP_001119807.1, NM_001126335.1 NP_001229965.1, NM_001243036.1 NP_055085.1, NM_014270.4 Gene ID: 11136 Splice variants: 2 splice variants

BAT1_HUMAN (UniProt)

Gene names: SLC7A9, BAT1
Protein names and data: BAT1_HUMAN, Full=B(0,+)-type amino acid transporter 1;Short=B(0,+)AT, Full=Glycoprotein-associated amino acid transporter b0,+AT1;Full=Solute carrier family 7 member 9; Length: 487 a.a., Mass: 53481 Da,
fasta formatted sequence

Function: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule
Cellular location: Membrane; Multi-pass membrane protein (Probable)
Tissue specificity: Kidney, small intestine, liver and placenta

Database cross-references

UniProt: P82251
NextBio: 42332
OMIM: 220100 604144
Ensembl: ENST00000023064
GeneCard: GC19M032830
PharmGenUCSF: SLC7A9
Guide to Pharmacology: SLC7A9 (900)
SLC7 family (900)

HGNC: HGNC:11067

Genetic variants

See also Ensembl:ENST00000023064