Protein name: NHE1 Aliases: APNH? Substrates: Na+, Li+, H+, NH4+ Transport type: Exchanger / Na+, H+ Tissue and cellular expression: Most mammalian cells, except macula densa and α- and β-intercalated cells of the kidney Subcellular expression: N/D Disease: Cancer, ischemia-reperfusion damage, arterial hypertension (?) [PMID: 24337822] Locus: 1p36.1-p35 Sequence ID: NP_003038.2, NM_003047.4 Gene ID: 6548 Splice variants: N/D

SL9A1_HUMAN (UniProt)

Gene names: SLC9A1, APNH1, NHE1
Protein names and data: SL9A1_HUMAN, Full=Sodium/hydrogen exchanger 1, Full=APNH;Full=Na(+)/H(+) antiporter, amiloride-sensitive;Full=Na(+)/H(+) exchanger 1;Short=NHE-1;Full=Solute carrier family 9 member 1; Length: 815 a.a., Mass: 90763 Da,
fasta formatted sequence

Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction
Cellular location: Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane
Tissue specificity: Kidney and intestine

Database cross-references

UniProt: P19634
NextBio: 25485
OMIM: 107310
Ensembl: ENST00000374086
GeneCard: GC01M027109
PharmGenUCSF: SLC9A1
Guide to Pharmacology: SLC9A1 (948)
SLC9 family of sodium/hydrogen exchangers (948)

HGNC: HGNC:11071

Genetic variants

See also Ensembl:ENST00000374086