Protein name: OST beta Aliases: N/D Substrates: steroids Transport type: N/D Tissue and cellular expression: liver, kidney, testes, ovary, adrenal gland Subcellular expression: N/D Disease: N/D Locus: 15q22.31 Sequence ID: NP_849190.2, NM_178859.3 Gene ID: 123264 Splice variants: N/D


Gene names: SLC51B, OSTB
Protein names and data: OSTB_HUMAN, Full=Organic solute transporter subunit beta;Short=OST-beta, Full=Solute carrier family 51 subunit beta; Length: 128 a.a., Mass: 14346 Da,
fasta formatted sequence

Function: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities
Cellular location: Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat

Database cross-references

UniProt: Q86UW2
NextBio: 81097
OMIM: 612085
GeneCard: GC15P066309
TCDB: 2.A.82.1.2
Guide to Pharmacology: SLC51B (1916)
SLC51 family of steroid-derived molecule transporters (1916)

HGNC: HGNC:29956

Genetic variants