Protein name: APC2 Aliases: ScaMC-3, MCSC2 Substrates: ATP-Mg2+, ATP, ADP, AMP, Pi Transport type: Exchanger / ATP-Mg, Pi Tissue and cellular expression: kidney, lung, small intestine, pancreas, brain, liver, skeletal muscle, heart Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 19p13.3 Sequence ID: NP_077008.2, NM_024103.2 Gene ID: 79085 Splice variants: N/D


Gene names: SLC25A23, APC2, MCSC2, SCAMC3
Protein names and data: SCMC3_HUMAN, Full=Calcium-binding mitochondrial carrier protein SCaMC-3, Full=Mitochondrial ATP-Mg/Pi carrier protein 2;Full=Mitochondrial Ca(2+)-dependent solute carrier protein 2;Full=Small calcium-binding mitochondrial carrier protein 3;Full=Solute carrier family 25 member 23; Length: 468 a.a., Mass: 52378 Da,
fasta formatted sequence

Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Present in various cell lines (at protein level). Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas

Database cross-references

UniProt: Q9BV35
NextBio: 67901
OMIM: 608746
Ensembl: ENST00000334510
GeneCard: GC19M006436
PharmGenUCSF: SLC25A23
Guide to Pharmacology: SLC25A23 (1078)
Mitochondrial nucleotide transporter subfamily (1078)

HGNC: HGNC:19375

Genetic variants

See also Ensembl:ENST00000334510