SLC16A7

Protein name: MCT2 Aliases: MOT2 Substrates: pyruvate, lactate, ketone bodies Transport type: Cotransporter / H+ Tissue and cellular expression: high expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain, leukocyte Subcellular expression: N/D Disease: N/D Locus: 12q13 Sequence ID: NP_001257551.1, NP_001257552.1, NP_004722.2, NM_004731.3 Gene ID: 9194 Splice variants: multiple splice variants listed in ENSG00000118596

MOT2_HUMAN (UniProt)

Gene names: SLC16A7, MCT2
Protein names and data: MOT2_HUMAN, Full=Monocarboxylate transporter 2;Short=MCT 2, Full=Solute carrier family 16 member 7; Length: 478 a.a., Mass: 52200 Da,
fasta formatted sequence
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells

Database cross-references

UniProt: O60669
NextBio: 34471
OMIM: 603654
Ensembl: ENST00000552432
GeneCard: GC12P059596
TCDB: 2.A.1.13.5
PharmGenUCSF: SLC16A7
Guide to Pharmacology: SLC16A7 (990)
SLC16 family of monocarboxylate transporters (990)
HGNC: HGNC:10928

Genetic variants

See also Ensembl:ENST00000552432