SLC5A12

Protein name: SMCT2 Aliases: N/D Substrates: short chain fatty acids Transport type: Cotransporter / Na+ Tissue and cellular expression: intestine, brain, retina, muscle Subcellular expression: N/D Disease: N/D Locus: 11p14.2 Sequence ID: NP_848593.2, NM_178498.3 Gene ID: 159963 Splice variants: N/D

SC5AC_HUMAN (UniProt)

Gene names: SLC5A12, SMCT2
Protein names and data: SC5AC_HUMAN, Full=Sodium-coupled monocarboxylate transporter 2, Full=Electroneutral sodium monocarboxylate cotransporter;Full=Low-affinity sodium-lactate cotransporter;Full=Solute carrier family 5 member 12; Length: 618 a.a., Mass: 67647 Da,
fasta formatted sequence
Function: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity)
Cellular location: Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity)

Database cross-references

UniProt: Q1EHB4
NextBio: 87917
OMIM: 612455
Ensembl: ENST00000396005
GeneCard: GC11M026648
PharmGenUCSF: SLC5A12
Guide to Pharmacology: SLC5A12 (923)
Sodium iodide symporter, sodium-dependent multivitamin transporter and sodium-coupled monocarboxylate transporters (923)
HGNC: HGNC:28750

Genetic variants

See also Ensembl:ENST00000396005