Protein name: N/D Aliases: PMP34, ANC1, ANT1 Substrates: CoA, FAD, NAD+, AMP, ADP, PAP, dPCoA, FMN Transport type: Exchanger / CoA; PAP, CoA, dPCoA; CoA,AMP; FAD, FMN; NAD+, AMP Tissue and cellular expression: brain, kidney, lung, heart, liver, pancreas Subcellular expression: peroxisomal membrane Disease: N/D Locus: 22q13.2 Sequence ID: NP_006349.1, NM_006358.2 Gene ID: 10478 Splice variants: N/D

PM34_HUMAN (UniProt)

Gene names: SLC25A17, PMP34
Protein names and data: PM34_HUMAN, Full=Peroxisomal membrane protein PMP34, Full=34 kDa peroxisomal membrane protein;Full=Solute carrier family 25 member 17; Length: 307 a.a., Mass: 34567 Da,
fasta formatted sequence

Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro
Cellular location: Cytoplasm. Peroxisome membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitous. Expressed in liver

Database cross-references

UniProt: O43808
NextBio: 39748
OMIM: 606795
Ensembl: ENST00000435456
GeneCard: GC22M040918
TCDB: 2.A.29.20.1
PharmGenUCSF: SLC25A17
Guide to Pharmacology: SLC25A17 (1072)
Mitochondrial nucleotide transporter subfamily (1072)

HGNC: HGNC:10987

Genetic variants

See also Ensembl:ENST00000435456