Protein name: SLC37A4, G6PT, SPX4 Aliases: glucose-6-phosphate Substrates: N/D Transport type: Exchanger / inorganic phosphate Tissue and cellular expression: ubiquitous, high levels in liver, kidney, prostate, pancreas, thymus, bone marrow, spleen Subcellular expression: N/D Disease: GSD-Ib/GSD-Ic, (OMIM232220/232240) Locus: 11q23.3 Sequence ID: NP_001157749.1, NM_001164277.1 NP_001157750.1, NM_001164278.1 NP_001157751.1, NM_001164279.1 NP_001157752.1, NM_001164280.1 NP_001458.1, NM_001467.5 Gene ID: 2542 Splice variants: N/D

G6PT1_HUMAN (UniProt)

Gene names: SLC37A4, G6PT, G6PT1, PRO0685, TRG19
Protein names and data: G6PT1_HUMAN, Full=Glucose-6-phosphate translocase, Full=Glucose-5-phosphate transporter;Full=Solute carrier family 37 member 4;Full=Transformation-related gene 19 protein;Short=TRG-19; Length: 429 a.a., Mass: 46360 Da,
fasta formatted sequence

Function: Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Mostly expressed in liver and kidney

Database cross-references

UniProt: O43826
NextBio: 10031
OMIM: 232220 232240 602671
GeneCard: GC11M119024
TCDB: 2.A.1.4.5
PharmGenUCSF: SLC37A4
Guide to Pharmacology: SLC37A4 (1168)
SLC37 family of phosphosugar/phosphate exchangers (1168)


Genetic variants