Protein name: ENT2 Aliases: N/D Substrates: N/D Transport type: Facilitated transporter Tissue and cellular expression: particularly abundant in skeletal muscle but widely expressed Subcellular expression: primarily plasma membrane-located, but has also been detected in nuclear membranes Disease: N/D Locus: 11q13 Sequence ID: NP_001523.2, NM_001532.2 Gene ID: 3177 Splice variants: exon 4 splice variant leading to N- terminally truncated, inactive protein (HNP36), exon 9 splice variant leading to C-terminally truncated, inactive protein (ENT2A)

S29A2_HUMAN (UniProt)

Gene names: SLC29A2, DER12, ENT2, HNP36
Protein names and data: S29A2_HUMAN, Full=Equilibrative nucleoside transporter 2, Full=36 kDa nucleolar protein HNP36;Full=Delayed-early response protein 12;Full=Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter;Short=Equilibrative NBMPR-insensitive nucleoside transporter;Full=Hydrophobic nucleolar protein, 36 kDa;Full=Nucleoside transporter, ei-type;Full=Solute carrier family 29 member 2; Length: 456 a.a., Mass: 50113 Da,
fasta formatted sequence

Function: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine
Cellular location: Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells
Tissue specificity: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues

Database cross-references

UniProt: Q14542
NextBio: 12610
OMIM: 602110
Ensembl: ENST00000546034
GeneCard: GC11M066363
PharmGenUCSF: SLC29A2
Guide to Pharmacology: SLC29A2 (1118)
SLC29 family (1118)

HGNC: HGNC:11004

Genetic variants

See also Ensembl:ENST00000546034