Protein name: 4F2hc Aliases: CD98hc, FRP Substrates: systems L, y+L, xc- and asc with light subunits SLC7A5-8 and SLC7A10-11 Transport type: Exchanger (see details in SLC7 table) Tissue and cellular expression: ubiquitous Subcellular expression: basolateral membrane Disease: cancer Locus: 11q13 Sequence ID: NP_001012680.1, NM_001012662.2 NP_001012682.1, NM_001012664.2 NP_001013269.1, NM_001013251.2 NP_002385.3, NM_002394.5 Gene ID: 6520 Splice variants: 6 splice variants

4F2_HUMAN (UniProt)

Gene names: SLC3A2, MDU1
Protein names and data: 4F2_HUMAN, Full=4F2 cell-surface antigen heavy chain;Short=4F2hc, Full=4F2 heavy chain antigen;Full=Lymphocyte activation antigen 4F2 large subunit;CD_antigen=CD98; Length: 630 a.a., Mass: 67994 Da,
fasta formatted sequence

Function: Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier
Cellular location: Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity)
Tissue specificity: Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2 BBe

Database cross-references

UniProt: P08195
NextBio: 25353
OMIM: 158070
Ensembl: ENST00000377892
GeneCard: GC11P062874
TCDB: 8.A.9.2.2
PharmGenUCSF: SLC3A2
Guide to Pharmacology: SLC3A2 (890)
SLC3 family (890)

HGNC: HGNC:11026

Genetic variants

See also Ensembl:ENST00000377892