Protein name: Sperm-NHE Aliases: N/D Substrates: Na+, H+ Transport type: N/D Tissue and cellular expression: Spermatozoa Subcellular expression: N/D Disease: Infertility (?) [PMID: 14634667] Locus: 3q13.2 Sequence ID: NP_898884.1, Gene ID: 285335 Splice variants: N/D

SL9C1_HUMAN (UniProt)

Gene names: SLC9C1, SLC9A10
Protein names and data: SL9C1_HUMAN, Full=Sodium/hydrogen exchanger 10, Full=Na(+)/H(+) exchanger 10;Short=NHE-10;Full=Solute carrier family 9 member 10;Full=Solute carrier family 9 member C1;Full=Sperm-specific Na(+)/H(+) exchanger;Short=sNHE; Length: 1177 a.a., Mass: 135206 Da,
fasta formatted sequence

Function: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity)
Cellular location: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein (By similarity)

Database cross-references

UniProt: Q4G0N8
NextBio: 95448
OMIM: 612738
Ensembl: ENST00000487372
GeneCard: GC03M112140
PharmGenUCSF: SLC9C1
Guide to Pharmacology: SLC9C1 (957)
SLC9 family of sodium/hydrogen exchangers (957)

HGNC: HGNC:31401

Genetic variants

See also Ensembl:ENST00000487372