SLC38A4

Protein name: SNAT4 Aliases: ATA3, NAT3, PAAT Substrates: A, N, C, G, S, T Transport type: Cotransporter / Na+ Tissue and cellular expression: brain, retina, liver, kidney, adipose tissue Subcellular expression: N/D Disease: N/D Locus: 12q13.11 Sequence ID: NP_001137296.1, NM_001143824.1 NP_060488.2, NM_018018.4 Gene ID: 55089 Splice variants: N/D

S38A4_HUMAN (UniProt)

Gene names: SLC38A4, ATA3, NAT3, SNAT4
Protein names and data: S38A4_HUMAN, Full=Sodium-coupled neutral amino acid transporter 4, Full=Amino acid transporter A3;Full=Na(+)-coupled neutral amino acid transporter 4;Full=Solute carrier family 38 member 4;Full=System A amino acid transporter 3;Full=System N amino acid transporter 3; Length: 547 a.a., Mass: 60764 Da,
fasta formatted sequence
Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels

Database cross-references

UniProt: Q969I6
NextBio: 58661
OMIM: 608065
Ensembl: ENST00000447411
GeneCard: GC12M046764
PharmGenUCSF: SLC38A4
Guide to Pharmacology: SLC38A4 (1171)
System A-like transporters (1171)
HGNC: HGNC:14679

Genetic variants

See also Ensembl:ENST00000447411