Protein name: TAT1, SLC26A8 Aliases: N/D Substrates: Cl-, HCO3-, OH- Transport type: Exchanger / Cl-, HCO3-, OH- Tissue and cellular expression: male germ cells, sperm Subcellular expression: N/D Disease: (male infertility) Locus: 6p21 Sequence ID: NP_001180405.1, NM_001193476.1 NP_443193.1, NM_052961.3 NP_619732.2, NM_138718.2 Gene ID: 116369 Splice variants: 3 mRNAs, 2 ORFs, +/- 2 exons

S26A8_HUMAN (UniProt)

Gene names: SLC26A8, TAT1
Protein names and data: S26A8_HUMAN, Full=Testis anion transporter 1, Full=Anion exchange transporter;Full=Solute carrier family 26 member 8; Length: 970 a.a., Mass: 109006 Da,
fasta formatted sequence

Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility
Cellular location: Membrane; Multi-pass membrane protein. Note=Located at the annulus ring structure within the sperm cell
Tissue specificity: Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa

Database cross-references

UniProt: Q96RN1
NextBio: 79881
OMIM: 608480
Ensembl: ENST00000490799
GeneCard: GC06M036675
PharmGenUCSF: SLC26A8
Guide to Pharmacology: SLC26A8 (1105)
Other SLC26 anion exchangers (1105)

HGNC: HGNC:14468

Genetic variants

See also Ensembl:ENST00000490799