Protein name: MCT4 Aliases: MOT4, MCT3 Substrates: lactate, ketone bodies Transport type: Cotransporter / H+ Tissue and cellular expression: skeletal muscle, chondrocytes, leukocytes, testis, lung, ovary, placenta, heart Subcellular expression: N/D Disease: N/D Locus: 17q25.3 Sequence ID: NP_001035887.1, NM_001042422.2 NP_001035888.1, NM_001042423.2 NP_001193879.1, NM_001206950.1 NP_001193880.1, NM_001206951.1 NP_001193881.1, NM_001206952.1 NP_004198.1, NM_004207.3 Gene ID: 9123 Splice variants: splice variants in non-coding region

MOT4_HUMAN (UniProt)

Gene names: SLC16A3, MCT4
Protein names and data: MOT4_HUMAN, Full=Monocarboxylate transporter 4;Short=MCT 4, Full=Solute carrier family 16 member 3; Length: 465 a.a., Mass: 49469 Da,
fasta formatted sequence

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in skeletal muscle

Database cross-references

UniProt: O15427
NextBio: 34193
OMIM: 603877
Ensembl: ENST00000582743
GeneCard: GC17P082228
TCDB: 2.A.1.13.6
PharmGenUCSF: SLC16A3
Guide to Pharmacology: SLC16A3 (989)
SLC16 family of monocarboxylate transporters (989)

HGNC: HGNC:10924

Genetic variants

See also Ensembl:ENST00000582743