SLC30A8

Protein name: N/D Aliases: ZnT8 Substrates: N/D Transport type: N/D Tissue and cellular expression: pancreas, thyroid, adrenal gland, testis Subcellular expression: secretory granule Disease: diabetes Locus: N/D Sequence ID: NP_001166282.1, NM_001172811.1 NP_001166284.1, NM_001172813.1 NP_001166285.1, NM_001172814.1 NP_001166286.1, NM_001172815.1 NP_776250.2, NM_173851.2 Gene ID: 169026 Splice variants: N/D

ZNT8_HUMAN (UniProt)

Gene names: SLC30A8, ZNT8
Protein names and data: ZNT8_HUMAN, Full=Zinc transporter 8;Short=ZnT-8, Full=Solute carrier family 30 member 8; Length: 369 a.a., Mass: 40755 Da,
fasta formatted sequence
Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells
Cellular location: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory granules (By similarity)
Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive

Database cross-references

UniProt: Q8IWU4
NextBio: 88780
OMIM: 125853 611145
Ensembl: ENST00000521243
GeneCard: GC08P116950
PharmGenUCSF: SLC30A8
Guide to Pharmacology: SLC30A8 (1128)
SLC30 zinc transporter family (1128)
HGNC: HGNC:20303

Genetic variants

Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM:125853]. See also Ensembl:ENST00000521243