Protein name: AE1 Aliases: Band 3 Substrates: chloride cicarbonate Transport type: Exchanger Tissue and cellular expression: erythrocytes, intercalated cells of renal collecting duct, heart, colon Subcellular expression: N/D Disease: hemolytic anemia, distal renal tubular acidosis Locus: 17q21-q22 Sequence ID: NP_000333.1, NM_000342.3 Gene ID: 6521 Splice variants: 2 splice variants

B3AT_HUMAN (UniProt)

Gene names: SLC4A1, AE1, DI, EPB3
Protein names and data: B3AT_HUMAN, Full=Band 3 anion transport protein, Full=Anion exchange protein 1;Short=AE 1;Short=Anion exchanger 1;Full=Solute carrier family 4 member 1;CD_antigen=CD233; Length: 911 a.a., Mass: 101792 Da,
fasta formatted sequence

Function: Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Erythrocytes

Database cross-references

UniProt: P02730
NextBio: 25367
OMIM: 109270 110500 112010 112050 130600 179800 601550 601551 611162 611590 612653
Ensembl: ENST00000262418
GeneCard: GC17M044249
TCDB: 2.A.31.1.1
PharmGenUCSF: SLC4A1
Guide to Pharmacology: SLC4A1 (904)
Anion exchangers (904)

HGNC: HGNC:11027

Genetic variants

Genetic variations in SLC4A1 are involved in resistance to malaria [MIM:611162]. See also Ensembl:ENST00000262418