Protein name: BTR1 Aliases: NaBC1 Substrates: sodium, borate Transport type: Cotransporter Tissue and cellular expression: kidney, salivary gland testis, thyroid, trachea Subcellular expression: N/D Disease: N/D Locus: 20p12 Sequence ID: NP_001167560.1, NM_001174089.1 NP_001167561.1, NM_001174090.1 NP_114423.1, NM_032034.3 Gene ID: 83959 Splice variants: 1

S4A11_HUMAN (UniProt)

Gene names: SLC4A11, BTR1
Protein names and data: S4A11_HUMAN, Full=Sodium bicarbonate transporter-like protein 11, Full=Bicarbonate transporter-related protein 1;Full=Sodium borate cotransporter 1;Short=NaBC1;Full=Solute carrier family 4 member 11; Length: 891 a.a., Mass: 99581 Da,
fasta formatted sequence

Function: Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter
Cellular location: Cell membrane. Membrane; Multi-pass membrane protein
Tissue specificity: Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes

Database cross-references

UniProt: Q8NBS3
NextBio: 73102
OMIM: 217400 217700 610206 613268
Ensembl: ENST00000437836
GeneCard: GC20M003203
TCDB: 2.A.31.4.1
PharmGenUCSF: SLC4A11
Guide to Pharmacology: SLC4A11 (913)
Sodium-dependent HCO3- transporters (913)

HGNC: HGNC:16438

Genetic variants

See also Ensembl:ENST00000437836