Protein name: CNT3 Aliases: N/D Substrates: N/D Transport type: concentrative 2:1 sodium: nucleoside 1:1 proton: nucleoside probably 1:1:1 sodium:proton:nucleoside Tissue and cellular expression: widely expressed, most abundant in mammary gland, pancreas, bone marrow, trachea, intestine Subcellular expression: primarily in plasma membrane, but intracellular in some cell types and splice variants Disease: N/D Locus: 9q22.2 Sequence ID: NP_001186562.1, NM_001199633.1 NP_071410.1, NM_022127.2 Gene ID: 64078 Splice variants: splice variant lacks the N-terminal 69 residues and is retained in the endoplasmic reticulum (but is still functional)

S28A3_HUMAN (UniProt)

Gene names: SLC28A3, CNT3
Protein names and data: S28A3_HUMAN, Full=Solute carrier family 28 member 3, Full=Concentrative Na(+)-nucleoside cotransporter 3;Short=CNT 3;Short=hCNT3; Length: 691 a.a., Mass: 76930 Da,
fasta formatted sequence

Function: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine
Cellular location: Membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart

Database cross-references

UniProt: Q9HAS3
NextBio: 65862
OMIM: 608269
Ensembl: ENST00000376238
GeneCard: GC09M084276
PharmGenUCSF: SLC28A3
Guide to Pharmacology: SLC28A3 (1116)
SLC28 family (1116)

HGNC: HGNC:16484

Genetic variants

See also Ensembl:ENST00000376238