Protein name: NCX1 Aliases: NACA, NCE Substrates: Na+, Ca2+ Transport type: Exchanger / Na+, Ca2+ Tissue and cellular expression: ubiquitous tissue distribution; specific splice variants found in brain, heart, kidney, pancreas Subcellular expression: N/D Disease: N/D Locus: 2p23-p22 Sequence ID: NP_001106271.1, NM_001112800.1 NP_001106272.1, NM_001112801.1 NP_001106273.1, NM_001112802.1 NP_001239553.1, NM_001252624.1 NP_066920.1, NM_021097.2 Gene ID: 6546 Splice variants: 17 splice variants, exon A splice variants in excitable tissues, exon B splice variants in all other tissues

NAC1_HUMAN (UniProt)

Gene names: SLC8A1, CNC, NCX1
Protein names and data: NAC1_HUMAN, Full=Sodium/calcium exchanger 1, Full=Na(+)/Ca(2+)-exchange protein 1;Flags: Precursor; Length: 973 a.a., Mass: 108547 Da,
fasta formatted sequence

Function: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung

Database cross-references

UniProt: P32418
NextBio: 25469
OMIM: 182305
Ensembl: ENST00000408028
GeneCard: GC02M040078
PharmGenUCSF: SLC8A1
Guide to Pharmacology: SLC8A1 (945)
SLC8 family of sodium/calcium exchangers (945)

HGNC: HGNC:11068

Genetic variants

See also Ensembl:ENST00000408028