SLC49A4

Protein name: DIRC2 Aliases: RCC4, FLJ14784 Substrates: unknown Transport type: unknown Tissue and cellular expression: pancreas, kidney, liver, placenta, heart Subcellular expression: predominantly localizes to the lysosome Disease: renal cell, prostate cancers Locus: 3q21.1 Sequence ID: NP_116228.1, NM_032839.2 Gene ID: 84925 Splice variants: isoform 2 differs from the canonical sequence as follows: aa 380-411, alternative sequence and aa 412-478 missing, no experimental confirmation.

DIRC2_HUMAN (UniProt)

Gene names: DIRC2
Protein names and data: DIRC2_HUMAN, Full=Disrupted in renal carcinoma protein 2, Full=Disrupted in renal cancer protein 2; Length: 478 a.a., Mass: 52088 Da,
fasta formatted sequence
Function: Electrogenic metabolite transporter
Disease:
Cellular location: Lysosome membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitous. Expressed in proximal tubular cells of the kidney

Database cross-references

UniProt: Q96SL1
NextBio: 75346
OMIM: 602773
Ensembl: ENST00000261038
GeneCard: GC03P122795
Guide to Pharmacology: SLC49A4 (1913)
SLC49 family of FLVCR-related heme transporters (1913)
HGNC: HGNC:16628

Genetic variants

See also Ensembl:ENST00000261038