SLCO1B1

Protein name: OATP1B1 Aliases: N/D Substrates: bile salts, organic anions Transport type: N/D Tissue and cellular expression: liver (hepatocytes) Subcellular expression: N/D Disease: statin-induced myopathy, Rotor syndrome Locus: 12p Sequence ID: NP_006437.3, NM_006446.4 Gene ID: 10599 Splice variants: N/D

SO1B1_HUMAN (UniProt)

Gene names: SLCO1B1 , LST1, OATP1B1, OATP2, OATPC, SLC21A6
Protein names and data: SO1B1_HUMAN , Full=Solute carrier organic anion transporter family member 1B1 , Full=Liver-specific organic anion transporter 1;Short=LST-1;Full=OATP-C;Full=Sodium-independent organic anion-transporting polypeptide 2;Short=OATP-2;Full=Solute carrier family 21 member 6; Length: 691 a.a., Mass: 76449 Da,
fasta formatted sequence

Function: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver
Disease:
Cellular location: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes
Tissue specificity: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte

Database cross-references

UniProt: Q9Y6L6
NextBio: 40250
OMIM: 237450 604843
Ensembl: ENST00000256958
GeneCard: GC12P021284
TCDB: 2.A.60.1.5
PharmGenUCSF: SLCO1B1
Guide2Pharmacology: 238
HGNC: HGNC:10959

Genetic variants

See also Ensembl:ENST00000256958