Protein name: PDS, Pendrin, SLC26A4 Aliases: N/D Substrates: I-, Cl-, HCO3- Transport type: Exchanger / I-, Cl-, HCO3- Tissue and cellular expression: cochlear, vestibular, epithelial cells, thyrocytes, type B intercalated cell, airway epithelial cell Subcellular expression: apical Disease: Pendred syndrome, deafness (DFNB4), enlargement of the vestibular acqueduct Locus: 7q31 Sequence ID: NP_000432.1, NM_000441.1 Gene ID: 5172 Splice variants: 1 mRNA, 1 ORF

S26A4_HUMAN (UniProt)

Gene names: SLC26A4, PDS
Protein names and data: S26A4_HUMAN, Full=Pendrin, Full=Sodium-independent chloride/iodide transporter;Full=Solute carrier family 26 member 4; Length: 780 a.a., Mass: 85723 Da,
fasta formatted sequence

Function: Sodium-independent transporter of chloride and iodide
Cellular location: Membrane; Multi-pass membrane protein (Probable)
Tissue specificity: High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues

Database cross-references

UniProt: O43511
NextBio: 20014
OMIM: 274600 600791 605646
Ensembl: ENST00000265715
GeneCard: GC07P107660
PharmGenUCSF: SLC26A4
Guide to Pharmacology: SLC26A4 (1100)
Chloride/bicarbonate exchangers (1100)


Genetic variants

See also Ensembl:ENST00000265715