Protein name: MCT3 Aliases: MOT3, REMP Substrates: lactate Transport type: Cotransporter / H+ (pH dependent but cotransport not confirmed experimentally) Tissue and cellular expression: retinal pigment epithelium, choroid plexus Subcellular expression: N/D Disease: N/D Locus: 22q112.3-q13.2 Sequence ID: NP_037488.2, NM_013356.2 Gene ID: 23539 Splice variants: several splice variants listed in ENSG00000100156

MOT3_HUMAN (UniProt)

Gene names: SLC16A8, MCT3
Protein names and data: MOT3_HUMAN, Full=Monocarboxylate transporter 3;Short=MCT 3, Full=Solute carrier family 16 member 8; Length: 504 a.a., Mass: 52319 Da,
fasta formatted sequence

Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Retinal pigment epithelium

Database cross-references

UniProt: O95907
NextBio: 46042
OMIM: 610409
Ensembl: ENST00000320521
GeneCard: GC22M039964
TCDB: 2.A.1.13.9
PharmGenUCSF: SLC16A8
Guide to Pharmacology: SLC16A8 (991)
SLC16 family of monocarboxylate transporters (991)

HGNC: HGNC:16270

Genetic variants

See also Ensembl:ENST00000320521