SLC11A1

Protein name: NRAMP1 Aliases: NRAMP, LSH Substrates: Mn2+, Fe2+, other divalent metal ions Transport type: Exchanger or C ? / H+ Tissue and cellular expression: phagolysosomes of phagocytes (macrophages, neutrophils) Subcellular expression: N/D Disease: mycobacterium tuberculosis, Buruli ulcer, autoimmune disease; e.g. IDDM Locus: 2q35 Sequence ID: NP_000569.3, NM_000578.3 Gene ID: 6556 Splice variants: N/D

NRAM1_HUMAN (UniProt)

Gene names: SLC11A1, LSH, NRAMP, NRAMP1
Protein names and data: NRAM1_HUMAN, Full=Natural resistance-associated macrophage protein 1;Short=NRAMP 1; Length: 550 a.a., Mass: 59872 Da,
fasta formatted sequence
Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes
Cellular location: Membrane; Multi-pass membrane protein (Probable)
Tissue specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver

Database cross-references

UniProt: P49279
NextBio: 25511
OMIM: 600266 607948 610446
Ensembl: ENST00000233202
GeneCard: GC02P218382
TCDB: 2.A.55.2.3
PharmGenUCSF: SLC11A1
Guide to Pharmacology: SLC11A1 (966)
SLC11 family of proton-coupled metal ion transporters (966)
HGNC: HGNC:10907

Genetic variants

Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIM:607948]. See also Ensembl:ENST00000233202