Protein name: GC1 (glutamate carrier 1) Aliases: N/D Substrates: glutamate Transport type: Cotransporter / glutamate, H+; E / glutamate, OH- Tissue and cellular expression: pancreas, brain, liver, testis, spleen, kidney, heart, lung, small intestine, pancreatic beta cells Subcellular expression: inner mitochondrial membrane Disease: early epileptic encephalopathy Locus: 11p15.5 Sequence ID: NP_001177989.1, NM_001191060.1 NP_001177990.1, NM_001191061.1 NP_078974.1, NM_024698.5 Gene ID: 79751 Splice variants: N/D

GHC1_HUMAN (UniProt)

Gene names: SLC25A22, GC1
Protein names and data: GHC1_HUMAN, Full=Mitochondrial glutamate carrier 1;Short=GC-1, Full=Glutamate/H(+) symporter 1;Full=Solute carrier family 25 member 22; Length: 323 a.a., Mass: 34470 Da,
fasta formatted sequence

Function: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
Tissue specificity: Highly expressed in most tissues

Database cross-references

UniProt: Q9H936
NextBio: 69195
OMIM: 609302 609304
Ensembl: ENST00000531214
GeneCard: GC11M000791
TCDB: 2.A.29.14.3
PharmGenUCSF: SLC25A22
Guide to Pharmacology: SLC25A22 (1058)
Mitochondrial amino acid transporter subfamily (1058)

HGNC: HGNC:19954

Genetic variants

See also Ensembl:ENST00000531214