Protein name: PiT-2 Aliases: amphotropic murine leukemia virus receptor 2, GLVR2, Glvr-2, MLVAR Substrates: inorganic phosphate (monovalent) Transport type: Cotransporter / Na+, H2PO4- Tissue and cellular expression: widely expressed, kidney (proximal tubule) Subcellular expression: apical membrane (kidney) Disease: idiopathic basal ganglia calcification (genetic defect) Locus: 8p111 Sequence ID: NP_001244109.1, NM_001257180.1 NP_001244110.1, NM_001257181.1 NP_006740.1, NM_006749.4 Gene ID: 6575 Splice variants: N/D

S20A2_HUMAN (UniProt)

Gene names: SLC20A2, GLVR2, PIT2
Protein names and data: S20A2_HUMAN, Full=Sodium-dependent phosphate transporter 2, Full=Gibbon ape leukemia virus receptor 2;Short=GLVR-2;Full=Phosphate transporter 2;Short=PiT-2;Short=Pit2;Short=hPit2;Full=Solute carrier family 20 member 2; Length: 652 a.a., Mass: 70392 Da,
fasta formatted sequence

Function: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitously expressed

Database cross-references

UniProt: Q08357
NextBio: 25583
OMIM: 158378 614540
Ensembl: ENST00000520262
GeneCard: GC08M042393
TCDB: 2.A.20.2.3
PharmGenUCSF: SLC20A2
Guide to Pharmacology: SLC20A2 (1018)
SLC20 family of sodium-dependent phosphate transporters (1018)

HGNC: HGNC:10947

Genetic variants

See also Ensembl:ENST00000520262