Protein name: APC3 Aliases: ScaMC-2, MCSC, PCSCL Substrates: N/D Transport type: Orphan transporter Tissue and cellular expression: brain, heart, skeletal muscle, liver, small intestine, lung, pancreas, testis Subcellular expression: inner mitochondrial membrane Disease: N/D Locus: 9q34.11 Sequence ID: NP_001006642.1, NM_001006641.1 NP_001006643.1, NM_001006642.1 NP_001252543.1, NP_443133.2, NM_052901.2 Gene ID: 114789 Splice variants: 4 splice variants


Gene names: SLC25A25, APC3, KIAA1896, MCSC3, SCAMC2, UNQ549/PRO1106
Protein names and data: SCMC2_HUMAN, Full=Calcium-binding mitochondrial carrier protein SCaMC-2, Full=Mitochondrial ATP-Mg/Pi carrier protein 3;Full=Mitochondrial Ca(2+)-dependent solute carrier protein 3;Full=Small calcium-binding mitochondrial carrier protein 2;Full=Solute carrier family 25 member 25; Length: 469 a.a., Mass: 52663 Da,
fasta formatted sequence

Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung

Database cross-references

UniProt: Q6KCM7
NextBio: 79195
OMIM: 608745
Ensembl: ENST00000433501
GeneCard: GC09P128068
TCDB: 2.A.29.23.1
PharmGenUCSF: SLC25A25
Guide to Pharmacology: SLC25A25 (1079)
Mitochondrial nucleotide transporter subfamily (1079)

HGNC: HGNC:20663

Genetic variants

See also Ensembl:ENST00000433501