Protein name: PiT-1 Aliases: gibbon ape leukemia virus receptor 1, GLVR1, Glvr1, FLJ41426, DKFZp686J2397 Substrates: inorganic phosphate (monovalent) Transport type: Cotransporter / Na+, H2PO4- Tissue and cellular expression: widely expressed Subcellular expression: N/D Disease: N/D Locus: 2q13 Sequence ID: NP_005406.3, NM_005415.4 Gene ID: 6574 Splice variants: N/D

S20A1_HUMAN (UniProt)

Gene names: SLC20A1, GLVR1, PIT1
Protein names and data: S20A1_HUMAN, Full=Sodium-dependent phosphate transporter 1, Full=Gibbon ape leukemia virus receptor 1;Short=GLVR-1;Full=Leukemia virus receptor 1 homolog;Full=Phosphate transporter 1;Short=PiT-1;Full=Solute carrier family 20 member 1; Length: 679 a.a., Mass: 73700 Da,
fasta formatted sequence

Function: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV)
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Ubiquitously expressed

Database cross-references

UniProt: Q8WUM9
NextBio: 25579
OMIM: 137570
Ensembl: ENST00000272542
GeneCard: GC02P112716
PharmGenUCSF: SLC20A1
Guide to Pharmacology: SLC20A1 (1017)
SLC20 family of sodium-dependent phosphate transporters (1017)

HGNC: HGNC:10946

Genetic variants

See also Ensembl:ENST00000272542