Protein name: NaPi-IIa Aliases: Napi-3, NPT2, npt2 Substrates: inorganic phosphate (divalent) Transport type: Cotransporter / Na, HPO42- Tissue and cellular expression: kidney (proximal tubule), osteoclasts, neurons Subcellular expression: apical membrane (kidney) Disease: G/XLH, G/ADHR, A/OHO, nephrocalciosis, hypo-phosphatemia, urolithiasis, osteoporosis Locus: 5q35 Sequence ID: NP_001161051.1, NM_001167579.1 NP_003043.3, NM_003052.4 Gene ID: 6569 Splice variants: N/D


Gene names: SLC34A1, NPT2, SLC17A2
Protein names and data: NPT2A_HUMAN, Full=Sodium-dependent phosphate transport protein 2A;Short=Sodium-phosphate transport protein 2A, Full=Na(+)-dependent phosphate cotransporter 2A;Full=NaPi-3;Full=Sodium/phosphate cotransporter 2A;Short=Na(+)/Pi cotransporter 2A;Short=NaPi-2a;Full=Solute carrier family 34 member 1; Length: 639 a.a., Mass: 68937 Da,
fasta formatted sequence

Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Kidney and lung

Database cross-references

UniProt: Q06495
NextBio: 25559
OMIM: 182309 612286 613388
Ensembl: ENST00000512593
GeneCard: GC05P177380
PharmGenUCSF: SLC34A1
Guide to Pharmacology: SLC34A1 (1135)
SLC34 family of sodium phosphate co-transporters (1135)

HGNC: HGNC:11019

Genetic variants

See also Ensembl:ENST00000512593