Protein name: NBCe2 Aliases: NBC4 Substrates: sodium bicarbonate (and/or carbonate) Transport type: Cotransporter Tissue and cellular expression: liver, testes, spleen Subcellular expression: N/D Disease: N/D Locus: 2p13 Sequence ID: NP_067019.3, NM_021196.3 NP_597812.1, NM_133478.2 Gene ID: 57835 Splice variants: >=1 splice variants

S4A5_HUMAN (UniProt)

Gene names: SLC4A5, NBC4
Protein names and data: S4A5_HUMAN, Full=Electrogenic sodium bicarbonate cotransporter 4, Full=NBCe2;Full=Solute carrier family 4 member 5; Length: 1137 a.a., Mass: 126255 Da,
fasta formatted sequence

Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH
Cellular location: Apical cell membrane; Multi-pass membrane protein. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla
Tissue specificity: Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle

Database cross-references

UniProt: Q9BY07
NextBio: 64831
OMIM: 606757
Ensembl: ENST00000394019
GeneCard: GC02M074217
TCDB: 2.A.31.2.8
PharmGenUCSF: SLC4A5
Guide to Pharmacology: SLC4A5 (909)
Sodium-dependent HCO3- transporters (909)

HGNC: HGNC:18168

Genetic variants

See also Ensembl:ENST00000394019