Protein name: NCKX2 Aliases: N/D Substrates: Na+, Ca2+, K+ Transport type: Exchanger / 4 Na+, Ca2+, K+ Tissue and cellular expression: brain, retinal cone, photoreceptors, retinal, ganglion cells Subcellular expression: plasma membrane Disease: N/D Locus: 9p22-p13 Sequence ID: NP_001180217.1, NM_001193288.2 NP_065077.1, NM_020344.3 Gene ID: 25769 Splice variants: N/D


Gene names: SLC24A2, NCKX2
Protein names and data: NCKX2_HUMAN, Full=Sodium/potassium/calcium exchanger 2, Full=Na(+)/K(+)/Ca(2+)-exchange protein 2;Full=Retinal cone Na-Ca+K exchanger;Full=Solute carrier family 24 member 2; Length: 661 a.a., Mass: 73664 Da,
fasta formatted sequence

Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)
Cellular location: Membrane; Multi-pass membrane protein

Database cross-references

UniProt: Q9UI40
NextBio: 46893
OMIM: 609838
Ensembl: ENST00000341998
GeneCard: GC09M019507
PharmGenUCSF: SLC24A2
Guide to Pharmacology: SLC24A2 (1046)
SLC24 family of sodium/potassium/calcium exchangers (1046)

HGNC: HGNC:10976

Genetic variants

See also Ensembl:ENST00000341998