Protein name: CHT Aliases: CHT1 Substrates: choline Transport type: N/D Tissue and cellular expression: spinal cord, medulla Subcellular expression: intracellular vesicles Disease: N/D Locus: 2q12 Sequence ID: NP_068587.1, NM_021815.2 Gene ID: 60482 Splice variants: N/D

SC5A7_HUMAN (UniProt)

Gene names: SLC5A7, CHT1
Protein names and data: SC5A7_HUMAN, Full=High affinity choline transporter 1, Full=Hemicholinium-3-sensitive choline transporter;Short=CHT;Full=Solute carrier family 5 member 7; Length: 580 a.a., Mass: 63204 Da,
fasta formatted sequence

Function: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent
Cellular location: Membrane; Multi-pass membrane protein
Tissue specificity: Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons

Database cross-references

UniProt: Q9GZV3
NextBio: 65355
OMIM: 608761
Ensembl: ENST00000409059
GeneCard: GC02P107969
PharmGenUCSF: SLC5A7
Guide to Pharmacology: SLC5A7 (914)
Choline transporter (914)

HGNC: HGNC:14025

Genetic variants

See also Ensembl:ENST00000409059