Protein name: N/D Aliases: RFVT1, RFT1, GPR172B, PERV-A receptor 2, GPCR42, PAR2, FLJ10060 Substrates: N/D Transport type: Na+, Cl-, pH-independent Tissue and cellular expression: placenta > small intestine, etc Subcellular expression: N/D Disease: N/D Locus: 17p13.3 Sequence ID: NP_001098047.1, NP_060456.3, Gene ID: 55065 Splice variants: N/D

S52A1_HUMAN (UniProt)

Gene names: SLC52A1, GPR172B, PAR2, RFT1
Protein names and data: S52A1_HUMAN, Full=Solute carrier family 52, riboflavin transporter, member 1, Full=Porcine endogenous retrovirus A receptor 2;Short=PERV-A receptor 2;Full=Protein GPR172B;Full=Riboflavin transporter 1;Short=hRFT1; Length: 448 a.a., Mass: 46317 Da,
fasta formatted sequence

Function: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A)
Cellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues

Database cross-references

UniProt: Q9NWF4
NextBio: 58569
OMIM: 607883
Ensembl: ENST00000424747
GeneCard: GC17M005032
TCDB: 9.A.53.1.1
Guide to Pharmacology: SLC52A1 (2571)
SLC52 family of riboflavin transporters (2571)

HGNC: HGNC:30225

Genetic variants

See also Ensembl:ENST00000424747