Protein name: SUT2, SLC26A7 Aliases: N/D Substrates: Cl-, HCO3-, OH-, SO42-, Ch: Cl- Transport type: Exchanger / Cl-, HCO3-, OH-, SO42-, Ch / Cl- Tissue and cellular expression: gastric parietal cells, type A intercalated cells, endothelial cells Subcellular expression: apical, lysosome Disease: (gastric hypochlorhydria, distal renal tubular acidosis) Locus: 8q23 Sequence ID: NP_439897.1, NM_052832.2 NP_599028.1, NM_134266.1 Gene ID: 115111 Splice variants: 2 mRNAs, 2 ORFs, Cterm var

S26A7_HUMAN (UniProt)

Gene names: SLC26A7, SUT2
Protein names and data: S26A7_HUMAN, Full=Anion exchange transporter, Full=Solute carrier family 26 member 7; Length: 656 a.a., Mass: 72213 Da,
fasta formatted sequence

Function: Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion
Cellular location: Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion
Tissue specificity: Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts

Database cross-references

UniProt: Q8TE54
NextBio: 79513
OMIM: 608479
Ensembl: ENST00000523719
GeneCard: GC08P091209
TCDB: 2.A.53.2.6
PharmGenUCSF: SLC26A7
Guide to Pharmacology: SLC26A7 (1102)
Anion channels (1102)

HGNC: HGNC:14467

Genetic variants

See also Ensembl:ENST00000523719